Patents by Inventor Brian Patrick Dwyer
Brian Patrick Dwyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220349907Abstract: Aspects of the disclosure relate to lateral flow assays having a number of different detection zones tuned to extend the dynamic range of the assay in indicating concentration of a hazardous contaminant in a test sample. Some aspects relate to assay reader devices configured with instructions to generate a result representing the concentration of the hazardous contaminant in the test sample based on some or all of the detection zones.Type: ApplicationFiled: July 15, 2022Publication date: November 3, 2022Inventors: Ray Isaacson, Brian Patrick Dwyer, Austin Jason Mckinnon
-
Patent number: 11391748Abstract: Aspects of the disclosure relate to lateral flow assays having a number of different detection zones tuned to extend the dynamic range of the assay in indicating concentration of a hazardous contaminant in a test sample. Some aspects relate to assay reader devices configured with instructions to generate a result representing the concentration of the hazardous contaminant in the test sample based on some or all of the detection zones.Type: GrantFiled: September 18, 2018Date of Patent: July 19, 2022Assignee: Becton, Dickinson and CompanyInventors: Ray Isaacson, Brian Patrick Dwyer, Austin Jason Mckinnon
-
Publication number: 20190086431Abstract: Aspects of the disclosure relate to lateral flow assays having a number of different detection zones tuned to extend the dynamic range of the assay in indicating concentration of a hazardous contaminant in a test sample. Some aspects relate to assay reader devices configured with instructions to generate a result representing the concentration of the hazardous contaminant in the test sample based on some or all of the detection zones.Type: ApplicationFiled: September 18, 2018Publication date: March 21, 2019Inventors: Ray Isaacson, Brian Patrick Dwyer, Austin Jason Mckinnon
-
Patent number: 6670393Abstract: The present invention provides novel carbamate-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof, wherein (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) n is an integer from 1 to 8; (d) X is an anion or polyanion; and (e) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions, and a kit for preparing the same.Type: GrantFiled: June 25, 2001Date of Patent: December 30, 2003Assignee: Promega Biosciences, Inc.Inventors: David Aaron Schwartz, Bob Dale Brown, Brian Patrick Dwyer
-
Patent number: 6638529Abstract: The present invention provides novel amide-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a lipophilic moiety; (c) R2, R3, and R4 are positively charged moieties, or at least one but not all of R2, R3, or R4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X− is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R3 or R4 must have an alkyl moiety of at least 10 carbon atoms.Type: GrantFiled: January 14, 2002Date of Patent: October 28, 2003Assignee: Genta IncorporatedInventors: David Aaron Schwartz, William J. Daily, Brian Patrick Dwyer, Kumar Srinivasan, Bob Dale Brown
-
Publication number: 20030097011Abstract: The present invention provides novel carbamate-based cationic lipids of the general structure: 1Type: ApplicationFiled: June 25, 2001Publication date: May 22, 2003Applicant: Promega Biosciences, Inc.Inventors: David Aaron Schwartz, Bob Dale Brown, Brian Patrick Dwyer
-
Publication number: 20020156237Abstract: The present invention provides novel amide-based cationic lipids of the general structure: 1Type: ApplicationFiled: January 14, 2002Publication date: October 24, 2002Applicant: Promega Biosciences, Inc.Inventors: David Aaron Schwartz, William J. Daily, Brian Patrick Dwyer, Kumar Srinivasan, Bob Dale Brown
-
Patent number: 6339173Abstract: The present invention provides novel amide-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a lipophilic moiety; (c) R2, R3, and R4 are positively charged moieties, or at least one but not all of R2,R3, or R4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X− is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R3 or R4 must have an alkyl moiety of at least 10 carbon atoms.Type: GrantFiled: June 7, 1999Date of Patent: January 15, 2002Assignee: Promega Biosciences, Inc.Inventors: David Aaron Schwartz, William J. Daily, Brian Patrick Dwyer, Kumar Srinivasan, Bob Dale Brown
-
Patent number: 6251939Abstract: The present invention provides novel carbamate-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof, wherein (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) n is an integer from 1 to 8; (d) X is an anion or polyanion; and (e) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions, and a kit for preparing the same.Type: GrantFiled: June 5, 1996Date of Patent: June 26, 2001Assignee: Promega Biosciences, Inc.Inventors: David Aaron Schwartz, Bob Dale Brown, Brian Patrick Dwyer
-
Patent number: 6172049Abstract: The present invention provides novel phosphonic acid-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) R3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X− is an anion or polyanion; (f) Y is N or 0, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.Type: GrantFiled: June 7, 1999Date of Patent: January 9, 2001Assignee: Promega Biosciences, Inc.Inventors: Brian Patrick Dwyer, Alexandre V. Lehedev, Bob Dale Brown, David Aaron Schwartz
-
Patent number: 6034135Abstract: The present invention provides novel dimeric cationic lipids. The present invention further provides compositions of these lipids with anionic or polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.Type: GrantFiled: March 6, 1997Date of Patent: March 7, 2000Assignee: Promega Biosciences, Inc.Inventors: David Aaron Schwartz, Brian Patrick Dwyer, William J. Daily, Kumar Srinivasan, Bob Dale Brown
-
Patent number: 6020526Abstract: The present invention provides novel amide-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R.sub.1 is H or a lipophilic moiety; (c) R.sub.2, R.sub.3, and R.sub.4 are positively charged moieties, or at least one but not all of R.sub.2, R.sub.3, or R.sub.4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X.sup.- is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R.sub.3 or R.sub.4 must have an alkyl moiety of at least 10 carbon atoms.Type: GrantFiled: July 22, 1996Date of Patent: February 1, 2000Assignee: Genta, IncorporatedInventors: David Aaron Schwartz, William J. Daily, Brian Patrick Dwyer, Kumar Srinivasan, Bob Dale Brown
-
Patent number: 5958901Abstract: The present invention provides novel phosphonic acid-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) R.sub.1 is a lipophilic moiety; (b) R.sub.2 is a positively charged moiety; (c) R.sub.3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X.sup.- is an anion or polyanion; (f) Y is N or O, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid.The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.Type: GrantFiled: June 5, 1996Date of Patent: September 28, 1999Assignee: Genta IncorporatedInventors: Brian Patrick Dwyer, Alexandre V. Lehedev, Bob Dale Brown, David Aaron Schwartz
-
Patent number: 5877220Abstract: The present invention provides amide-based oligomeric cationic lipids. The present invention further provides compositions of these amide-based cationic lipids with anionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.Type: GrantFiled: March 6, 1997Date of Patent: March 2, 1999Assignee: Genta, IncorporatedInventors: David Aaron Schwartz, Brian Patrick Dwyer, William J. Daily, Kumar Srinivasan, Bob Dale Brown