Abstract: A catheter includes a shaft including a proximal end and a distal end, an electrical conductor coupled to the catheter, and an electrode coupled to the electrical conductor. The electrode includes at least one recessed portion, and an impedance reduction layer disposed in the at least one recessed portion. The impedance reduction layer has a thickness less than a depth of the recessed portion.

Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Abstract: A method of forming a spline for an electrode assembly includes providing a structural member including a first surface and a second surface. The method also includes providing a flexible circuit assembly including a plurality of electrodes and at least one flexible circuit substrate having a contact surface and an outer surface opposite the contact surface. The plurality of electrodes are disposed on the outer surface of the at least one flexible circuit substrate. The method includes positioning the flexible circuit assembly relative to the structural member such that a first set of electrodes is aligned with the first surface and a second set of electrodes is aligned with the second surface. The method also includes coupling the at least one flexible circuit substrate to at least one of the structural member and the at least one flexible circuit substrate.

Abstract: Disclosed herein is a multi-electrode catheter system including an amplifier stage and an amplifier interface. The amplifier stage includes at least a first quantity of amplifier channels. The amplifier interface includes a first interface having at least the first quantity of interface channels. The amplifier channels are respectively electrically coupled to the interface channels The amplifier interface includes a second interface having a second quantity of catheter channels, the second quantity being greater than the first quantity. The catheter channels are configured to be respectively electrically coupled to corresponding electrode leads of a multi-electrode catheter. The amplifier interface includes a switching matrix electrically coupled between the first interface and the second interface. The switching matrix is configured to selectively electrically couple a selected subset of catheter channels to respective interface channels of the first quantity of interface channels.

Abstract: A catheter for electrophysiological measurement can include a catheter shaft including a proximal end and a distal end. An electrical conductor can be attached to the catheter. In some examples, a catheter tip portion can be located at the distal end of the catheter shaft. The catheter tip portion can include an electrical conductor and an electrode. In some examples, the electrical conductor can be a trace along a flexible circuit. The electrical conductor can be configured to be communicatively coupled to an ECU, and the electrode can be disposed on the electrical conductor. In various examples, a contact surface area of the electrode can include an impedance reduction layer.

Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Abstract: Methods, systems, and computer readable media for integrating medical imaging data in a data warehouse are disclosed. According to one method, the method occurs at a data warehouse management server that manages a data warehouse system. The data warehouse management server includes at least one processor. The method includes receiving medical imaging data including imaging metadata from an imaging related data source. The method also includes storing the imaging metadata in the data warehouse. The method further includes performing data processing using the imaging metadata and other healthcare related data stored in the data warehouse, wherein the other healthcare related data is from one or more different data sources.

Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Abstract: Methods, systems, and computer readable media for integrating medical imaging data in a data warehouse are disclosed. According to one method, the method occurs at a data warehouse management server that manages a data warehouse system. The data warehouse management server includes at least one processor. The method includes receiving medical imaging data including imaging metadata from an imaging related data source. The method also includes storing the imaging metadata in the data warehouse. The method further includes performing data processing using the imaging metadata and other healthcare related data stored in the data warehouse, wherein the other healthcare related data is from one or more different data sources.

Abstract: A method for passivating a biomaterial surface includes exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma. The biomaterial surface may be removably secured within a chamber of a treatment system, which communicates the therapeutic electrical energy to the biomaterial surface while interfacing the biomaterial surface with blood or plasma.

Abstract: A method for passivating a biomaterial surface includes exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma. The biomaterial surface may be removably secured within a chamber of a treatment system, which communicates the therapeutic electrical energy to the biomaterial surface while interfacing the biomaterial surface with blood or plasma.

Abstract: A deflectable sheath with increased range of curvature for human use is provided. The improvement focuses on the use of different durometer polymers that compose the lumen in the portion of deflection. The use of differing durometer polymers allow the deflectable sheath to be bent in a multitude of asymmetric curvature radii therefore providing the physician with a sheath that can traverse different regions of the body than with previous sheaths.

Abstract: A medical balloon for attachment to a catheter tube, and method of making the balloon. The balloon comprises a plurality of co-extruded and coextensive layers of different polymeric materials (20A, 20B) at least one of which is a base structural layer (20B) and the other of which (20A) is formed of polyethylene and copolymers thereof or of SELAR. The base structural layer is thicker than the other layer.

Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Abstract: An introducer assembly includes a sheath having a sheath proximal end and distal end, and a passage therethrough. The introducer assembly further includes a handle assembly disposed at an angle of about 10-30 degrees relative to the sheath axis. In addition, the introducer assembly includes a dilator having a grip portion, such as a recessed grip portion.

Abstract: A system and method for conditioning surfaces of a body in vivo includes providing an electrical energy source, coupling the electric energy source to the surface, and delivering electropositive current from the electrical energy source to the surface so as to generate a sub-threshold current density on the surface. In preferred embodiments, the sub-threshold electropositive current density is between about 0.001 and about 1.0 mA/cm2.

Abstract: A system for minimizing and/or eliminating coagulative or mineral deposits on respective blood-contacting surfaces of implanted medical devices includes an implantable system having a current generating device that is electrically coupled to at least first and second electrodes for developing a current therebetween. The at least first and second electrodes are disposed across a patient's thoracic cavity in a manner so that a particular implanted medical device having at least a portion thereof that is fabricated from an electrically conductive material is disposed in a path substantially between such electrodes, thereby focusing the generated electrical current at the electrically conductive portion of the implanted medical device for therapeutic treatment thereat.