Patents by Inventor Brian R. Bear

Brian R. Bear has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of ATP binding cassette transporters
    Patent number: 8524767
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: September 3, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark T. Miller, Sara S. Hadida Ruah, Brian R. Bear, Peter D. J. Grootenhuis, Jason McCartney
  • Pyrimidine Derivatives for Treatment of Hyperproliferative Disorders
    Publication number: 20110098301
    Abstract: Pyrimidine derivatives of formula pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.
    Type: Application
    Filed: March 9, 2006
    Publication date: April 28, 2011
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Julie A. Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yi, Yuanwei Chen, Jianqing Chen, Brian R. Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu
  • PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS
    Publication number: 20100075967
    Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
    Type: Application
    Filed: August 28, 2009
    Publication date: March 25, 2010
    Applicant: BAYER PHARMACEUTICALS CORPORATION
    Inventors: Julie A. Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yi, Yuanwei Chen, Jianging Chen, Brian R. Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu, Martin F. Hentemann, Ann-Marie Bullion, Manoj Patel
  • Pyrimidine derivatives for treatment of hyperproliferative disorders
    Patent number: 7678804
    Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: March 16, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Julie A. Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yi, Yuanwei Chen, Jianqing Chen, Brian R. Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu, Martin F. Hentemann, Ann-Marie Bullion, Manoj Patel
  • Pyrimidine Derivatives
    Publication number: 20090286785
    Abstract: This invention relates to novel compounds (I) and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
    Type: Application
    Filed: April 7, 2006
    Publication date: November 19, 2009
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Dhanapalan Nagarathnam, Yuanwei Chen, Wenlang Fu, Donald Bierer, Ming Wang, Michael Brands, Yamin Wang, Brian R. Bear
  • Pyrimidine Derivatives
    Publication number: 20090258888
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
    Type: Application
    Filed: April 7, 2006
    Publication date: October 15, 2009
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Dhanapalan Nagarathnam, Yuanwei Chen, Wenlang Fu, Donald Bierer, Ming Wang, Michael Brands, Yamin Wang, Brian R. Bear, Aaron Schmitt, Eric Mull, David Miller, Jin Zhao
  • Pyrimidine derivatives for treatment of hyperproliferative disorders
    Patent number: 7582646
    Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: September 1, 2009
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Julie A. Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yi, Yuanwei Chen, Jianqing Chen, Brian R. Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu, Martin F. Hentemann, Ann-Marie Bullion, Manoj Patel