Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: A heat-pump system includes a compressor, an outdoor heating exchanger, an indoor heat exchanger, an expansion device, and a supplemental heater. The outdoor heat exchanger is in fluid communication with the compressor. The indoor heat exchanger is in fluid communication with the compressor. The expansion device is in fluid communication with the indoor and outdoor heat exchangers. The supplemental heater includes a burner and a working-fluid conduit. The burner is configured to burn a fuel and heat the working-fluid conduit. When the heat-pump system is operating in a heating mode, the indoor heat exchanger receives working fluid from the working-fluid conduit such that the working fluid flows from an outlet of the working-fluid conduit to an inlet of the indoor heat exchanger.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A refrigeration system of a building includes: a compressor module configured to, in response to a determination that an amount of a refrigerant of the refrigeration system that is present outside of the refrigeration system and within the building is greater than a first predetermined amount, maintain a compressor off continuously for a predetermined period; and a fan module configured to, in response to the determination, maintain a fan on continuously for at least the predetermined period, and where the compressor module is further configured to, without receiving input indicative of a reset of the refrigeration system, after the compressor has been off for the predetermined period and the amount of refrigerant that is present outside of the refrigeration system within the building is less than a second predetermined amount, selectively turn the compressor on.

Abstract: A cooling system that may include a source of liquid natural refrigerant, a heat exchanger in communication with the source of liquid natural refrigerant that is configured to convert the liquid natural refrigerant into a gaseous natural refrigerant, a compressor in communication with the heat exchanger and configured to increase a temperature and pressure of the gaseous natural refrigerant received from the heat exchanger, and an exhaust device in communication with the compressor and configured to expel the gaseous natural refrigerant received from the compressor to air of an external ambient environment. The exhaust device includes a membrane that permits the gaseous natural refrigerant to exit the exhaust device while preventing or at least minimizing the air of the external ambient environment from entering the exhaust device.

Abstract: A climate-control system may include a compressor, a thermal storage device, an outdoor heat exchanger, an indoor heat exchanger, a first expansion device, and a second expansion device. The compressor may include an intermediate-pressure inlet, an intermediate-pressure outlet, a discharge outlet, a suction-pressure pocket, and a plurality of compression pockets. The thermal storage device may include a conduit and a phase-change material surrounding the conduit. The first expansion valve, the second expansion valve, the outdoor heat exchanger, the indoor heat exchanger, and the thermal storage device may be in fluid communication with the compressor. The climate-control system is operable in a charging mode and a discharging mode, and is operable in a cooling mode and a heating mode. The thermal storage device may be configured to absorb heat from a working fluid or to transfer heat to the working fluid.

Abstract: A heating system of a building includes: a solar heater configured to receive sunlight and to at least one of absorb heat into a refrigerant and augment heat absorbed into the refrigerant; a compressor configured to compress the refrigerant that vaporized via absorption of heat; a first heat exchanger configured to transfer heat from the refrigerant to water; an expansion valve configured to reduce at least one of a temperature and a pressure of the refrigerant after the transfer of heat from the refrigerant to water; a second heat exchanger configured to transfer heat from water output from the first heat exchanger to air passing the second heat exchanger before flowing into the building; a pump configured to pump the water from the solar heater to the second heat exchanger; and a blower configured to blow air past the second heat exchanger and into the building.

Abstract: A refrigerant control system includes: a reversing valve including: a first inlet configured to receive refrigerant output from a condenser; a first outlet configured to output refrigerant to an inlet of an evaporator located inside of a building; a second inlet configured to receive refrigerant output from the evaporator; and a second outlet configured to output refrigerant to an inlet of a compressor that pumps refrigerant to the condenser; a reversing module configured to: selectively actuate the reversing valve to a first position such that: refrigerant flows directly from the second inlet to the second outlet; and refrigerant flows directly from the first inlet to the first outlet; and selectively actuate the reversing valve to a second position such that: refrigerant flows directly from the second inlet to the first outlet; and refrigerant flows directly from the first inlet to the second outlet.

Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a first portion of a refrigeration system within a building; and an isolation module configured to selectively open and close an isolation valve of the refrigeration system and to, via the isolation valve, maintain the amount of refrigerant within the first portion within the building below a predetermined amount of the refrigerant.

Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a refrigeration system of a building; a leak module configured to diagnose that a leak is present in the refrigeration system based on the amount of refrigerant; and at least one module configured to take at least one remedial action in response to the diagnosis that the leak is present in the refrigeration system.

Abstract: A system for charging an outdoor unit with refrigerant includes a sensor configured to measure a refrigerant concentration and a user device configured to receive the measured refrigerant concentration. The system includes that the user device is configured to, in response to the measured refrigerant concentration exceeding a threshold, generate and display an alert on a user interface of the user device indicating the measured refrigerant concentration exceeds the threshold.

Abstract: An example refrigeration system includes an indoor fluid loop, an outdoor fluid loop, and a heat exchanger assembly. The indoor fluid loop circulates a first working fluid. The outdoor fluid loop circulates a second working fluid that is different from the first working fluid and is separated from the indoor fluid loop by a wall of a structure. The heat exchanger assembly is mounted within the wall of the structure. The heat exchanger assembly includes a heat exchanger and a housing, where the heat exchanger is disposed within an internal space defined by the housing. The housing supports the heat exchanger within the internal space and is mounted to a structure of the wall.

Abstract: A heating and cooling (HVAC) system that includes a compressor; a first heat exchanger; a second heat exchanger; a first expansion valve positioned between the first heat exchanger and the second heat exchanger; a first reversing valve that permits the system to operate in a first mode and a second mode; and a thermal battery including a phase change material therein that is configured to selectively store and release thermal energy received from a working fluid.

Abstract: An indoor air quality (IAQ) system for a building includes an IAQ sensor that is located within the building and that is configured to measure an IAQ parameter. The IAQ parameter is one of: an amount of particulate of at least a predetermined size present in air; an amount of volatile organic compounds (VOCs) present in air; and an amount of carbon dioxide present in air. A mitigation module is configured to: selectively turn on a mitigation device based on a comparison of the IAQ parameter with a first ON threshold and a second ON threshold; and selectively turn off the mitigation device based on a comparison of the IAQ parameter with an OFF threshold. A clean module is configured to determine a clean value for the IAQ parameter. A thresholds module is configured to, based on the clean value, determine the first ON threshold and the OFF threshold.

Abstract: A refrigerant measurement adjustment system includes: a refrigerant sensor for a building and configured to measure an amount of refrigerant present in air outside of a refrigeration system of the building; and an adjustment module configured to: adjust the amount of refrigerant measured based on an adjustment to produce an adjusted amount; and determine the adjustment based on at least one of: an air temperature; an air pressure; a relative humidity of air; a mode of operation of the refrigeration system; a change in the measurements of the refrigerant sensor over time; and whether a blower that blows air across a heat exchanger of the refrigeration system located within the building is on.

Abstract: A system for charging an outdoor unit with refrigerant includes a sensor configured to measure a refrigerant concentration and a user device configured to receive the measured refrigerant concentration. The system includes that the user device is configured to, in response to the measured refrigerant concentration exceeding a threshold, generate and display an alert on a user interface of the user device indicating the measured refrigerant concentration exceeds the threshold.

Abstract: A cooling system that may include a source of liquid natural refrigerant, a heat exchanger in communication with the source of liquid natural refrigerant that is configured to convert the liquid natural refrigerant into a gaseous natural refrigerant, a compressor in communication with the heat exchanger and configured to increase a temperature and pressure of the gaseous natural refrigerant received from the heat exchanger, and an exhaust device in communication with the compressor and configured to expel the gaseous natural refrigerant received from the compressor to air of an external ambient environment. The exhaust device includes a membrane that permits the gaseous natural refrigerant to exit the exhaust device while preventing or at least minimizing the air of the external ambient environment from entering the exhaust device.

Abstract: An indoor air quality (IAQ) system for a building includes an IAQ sensor that is located within the building and that is configured to measure an IAQ parameter. The IAQ parameter is one of: an amount of particulate of at least a predetermined size present in air; an amount of volatile organic compounds (VOCs) present in air; and an amount of carbon dioxide present in air. A mitigation module is configured to: selectively turn on a mitigation device based on a comparison of the IAQ parameter with a first ON threshold and a second ON threshold; and selectively turn off the mitigation device based on a comparison of the IAQ parameter with an OFF threshold. A clean module is configured to determine a clean value for the IAQ parameter. A thresholds module is configured to, based on the clean value, determine the first ON threshold and the OFF threshold.

Abstract: An example refrigeration system includes an indoor fluid loop, an outdoor fluid loop, and a heat exchanger assembly. The indoor fluid loop circulates a first working fluid. The outdoor fluid loop circulates a second working fluid that is different from the first working fluid and is separated from the indoor fluid loop by a wall of a structure. The heat exchanger assembly is mounted within the wall of the structure. The heat exchanger assembly includes a heat exchanger and a housing, where the heat exchanger is disposed within an internal space defined by the housing. The housing supports the heat exchanger within the internal space and is mounted to a structure of the wall.

Abstract: A heat-pump system may include a compressor, an outdoor heating exchanger, an indoor heat exchanger, an expansion device, and a supplemental heater. The outdoor heat exchanger may be in fluid communication with the compressor. The indoor heat exchanger may be in fluid communication with the compressor. The expansion device may be in fluid communication with the indoor and outdoor heat exchangers. The supplemental heater may include a burner and a working-fluid conduit. The burner may be configured to burn a fuel and heat the working-fluid conduit. When the heat-pump system is operating in a heating mode, the indoor heat exchanger may receive working fluid from the working-fluid conduit such that the working fluid flows from an outlet of the working-fluid conduit to an inlet of the indoor heat exchanger.