Abstract: Embodiments of a controlled odor emission system and device include an odor presentation port tube and an odor tray securely retained against a platform, a valve housing securable to the platform adjacent the tray, a valve secured within the valve housing and an actuator for moving the valve. By controlling movement of the valve, precise amounts of an odor can be dispensed under programmatic control for training animals. Further, a system incorporating a central control unit and a reward dispenser in communication with an odor emission device to facilitate animal training.

Abstract: Embodiments of a controlled odor emission system and device include an odor presentation port tube and an odor tray securely retained against a platform, a valve housing securable to the platform adjacent the tray, a valve secured within the valve housing and an actuator for moving the valve. By controlling movement of the valve, precise amounts of an odor can be dispensed under programmatic control for training animals. Further, a system incorporating a central control unit and a reward dispenser in communication with an odor emission device to facilitate animal training.

Abstract: The present disclosure pertains to systems and methods for monitoring electrical arc events in an electric power system. In one embodiment, a system may comprise an arc flash detection (AFD) unit to detect electromagnetic radiation generated by an electrical arc event, a primary protection relay to generate measurements of an electric current, and an integrator. In various embodiments, the integrator may comprise a communication port to receive the detection of the electrical arc event and the measurements of the electric current. The integrator may also comprise a processing subsystem to validate the detection of the electrical arc and generate protective actions to interrupt the flow of the current to the electrical arc event.

Abstract: The present disclosure pertains to systems and methods for monitoring electrical arc events in an electric power system. In one embodiment, a system may comprise an arc flash detection (AFD) unit to detect electromagnetic radiation generated by an electrical arc event, a primary protection relay to generate measurements of an electric current, and an integrator. In various embodiments, the integrator may comprise a communication port to receive the detection of the electrical arc event and the measurements of the electric current. The integrator may also comprise a processing subsystem to validate the detection of the electrical arc and generate protective actions to interrupt the flow of the current to the electrical arc event.

Abstract: A composition including genetically modified leukocytes is provided, where the genetically modified leukocytes contains a gene or expresses a protein that confers reversible resistance to glucocorticoids. In various aspects, the gene that confers resistance to glucocorticoids encodes 11-beta-dehydrogenase. Administering such genetically modified leukocytes provides leukocyte functions in treating one or more auto-immune, inflammatory, infectious or cancerous diseases or disorders, where the leukocytes are resistant to the effects of glucocorticoids such as alterations of numerous gene transcriptions in the leukocytes. Methods of reversing the glucocorticoid resistance in such genetically modified leukocytes are also provided by administering inhibitors of 11-beta-hydroxysteroid dehydrogenase. Methods of modifying the growth of these genetically modified leukocytes, or identification of candidate inhibitors of glucocorticoid resistance based on these genetically modified leukocytes, are also provided.

Abstract: A communicator for autonomous monitoring, detecting, and tracking of movement and orientation of a portion of a body of a wearer is disclosed. The communicator includes a sensor configured to detect a translational and/or rotational movement of the portion of the body of the wearer; an altimeter to measure changes in altitude of the portion of the body of the wearer; and a processor configured to determine an orientation and/or position of the portion of the body of the wearer. The processor further configured to compensate for the measured changes in altitude. The sensor is implemented at least by one of the following: accelerometer(s), gyroscope(s), and/or magnetometer(s).

Abstract: A communicator for autonomous monitoring, detecting, and tracking of movement and orientation of a portion of a body of a wearer is disclosed. The communicator includes a sensor configured to detect a translational and/or rotational movement of the portion of the body of the wearer; an altimeter to measure changes in altitude of the portion of the body of the wearer; and a processor configured to determine an orientation and/or position of the portion of the body of the wearer. The processor further configured to compensate for the measured changes in altitude. The sensor is implemented at least by one of the following: accelerometer(s), gyroscope(s), and/or magnetometer(s).

Abstract: The present disclosure relates to systems and methods for detection of a failed communication link and rerouting network traffic around the failure. One embodiment of a system consistent with the present disclosure may comprise a communication subsystem in communication with the data network and configured to transmit information to a recipient. The system may also include a confirmatory signal subsystem configured to generate a confirmatory signal. The confirmatory signal may be inserted into a stream of data to be transmitted to the recipient through a first communication path. Upon detection of a disruption in the confirmatory signal, a failover subsystem configured to reroute the stream of network data to be transmitted to the recipient through a second communication path. The second communication path may comprise one or more physical connections in the network that are distinct from the first communication path.

Abstract: The present disclosure relates to systems and methods for detection of a failed communication link and rerouting network traffic around the failure. One embodiment of a system consistent with the present disclosure may comprise a communication subsystem in communication with the data network and configured to transmit information to a recipient. The system may also include a confirmatory signal subsystem configured to generate a confirmatory signal. The confirmatory signal may be inserted into a stream of data to be transmitted to the recipient through a first communication path. Upon detection of a disruption in the confirmatory signal, a failover subsystem configured to reroute the stream of network data to be transmitted to the recipient through a second communication path. The second communication path may comprise one or more physical connections in the network that are distinct from the first communication path.

Abstract: The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.

Abstract: Molded articles formed of polystyrene or other polymers containing an aromatic moiety can be derivatized on the surface of the article by subjecting the molded article to a chemical reaction wherein the reaction media utilizes tetramethylsulfone as the reactant solvent and a suitable substituent group which is substituted on to the aromatic moiety of the polystyrene or other polymer by electrophilic substitution. By choosing the substituent group to further include a leaving group, further substitution of the primary substituent can be effected normally by nucleophilic substitution reaction. In this way, biologically important molecules can be attached to a polystyrene or other aromatic containing polymer without effecting certain properties of the molded article such as its optical or spectroscopic clarity.

Abstract: The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.

Abstract: Disclosed are amino acid sequences of the late 64 kilodalton protein of human cytomegalovirus (HCMVgp64), useful in diagnosing and preventing HCMV infections.

Abstract: A DNA probe has been isolated which is capable of hybridizing to an oligonucleotide sequence coding for a polypeptide from a major 64 Kilodalton protein of human cytomegalovirus (HCMVgp64). The probe has a sequence of at least seventeen (17) to as many as seven hundred twenty-one (721) nucleotides. The DNA fragments coding for the major late protein of human cytomegalovirus (HCMVgp64) may be hybridized to DNA fragments of HCMV DNA from an individual having human cytomegalovirus infection. The major late protein of human cytomegalovirus (HCMVgp64) also reacts with T-lymphocytes of an individual after natural infection of that individual with human cytomegalovirus. Thus, the HCMVgp64 protein may be used as a vaccine to prevent HCMV infection.

Abstract: The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.

Abstract: The present invention is directed to complexes comprising an isolated MHC subunit component, an antigenic peptide and, in some cases, an effector component. The antigenic peptide is associated with the antigen binding site of the MHC subunit component. These complexes are useful in treating autoimmune disease.

Abstract: The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.

Abstract: Intracellularly cleavable derivatives of toxic compounds including antibiotics are described.

Abstract: Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.

Abstract: The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X--MHC--peptide or MHc--peptide--X wherein X represents a functional moiety selected from a toxin and a labeling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and "peptide" represents an antigenic peptide sequence associated with an autoantigen;--represents a covalent bond or a linker bound to X and MHC or to X and peptide by covalent bonds; and--represents a covalent bond, a noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to target helper T-cells which are specifically immunoreactive with autoantigens.