Abstract: A system for generating a user interface described herein can include a processor to detect a type of the system based on hardware components residing within the system or coupled to the system and determine a user interface manager to execute based on the type of the system. The processor can also execute the user interface manager to generate a user interface for the system, wherein the type of the user interface manager comprises a plurality of rules to indicate a layout of the user interface.

Abstract: Described herein is a method of generating in-vitro differentiated airway basal cells and compositions thereof. Also described herein is a method of treating a pulmonary disease comprising administering the in-vitro differentiated airway basal cells and compositions thereof. In another aspect, described herein is a disease model comprising patient-derived or genetically modified in-vitro differentiated airway basal cells and compositions thereof.

Abstract: Described herein is a method of generating in-vitro differentiated airway basal cells and compositions thereof. Also described herein is a method of treating a pulmonary disease comprising administering the in-vitro differentiated airway basal cells and compositions thereof. In another aspect, described herein is a disease model comprising patient-derived or genetically modified in-vitro differentiated airway basal cells and compositions thereof.

Abstract: The present invention relates to the medical field, in particular to gene editing as a therapeutic approach for the treatment of metabolic diseases affecting the erythroid lineage in a mammalian subject. In invention particular embodiment it refers to the combination of cell reprograming and gene editing for PKD correction as a first example of the potential application of these advanced technologies to metabolic diseases affecting the erythroid lineage. In this sense, PKD patient-specific iPSCs were efficiently generated from PB-MNCs (peripheral blood mononuclear cells) by a SeV non-integrative system and efficiently use to treat pyruvate kinase deficiency. The gene editing strategy for PKLR gene correction was also successfully applied directly to hematopoietic progenitors.

Abstract: Nucleases and methods of using these nucleases for alteration of a CFTR gene and generation of cells and animal models.

Abstract: Nucleases and methods of using these nucleases for alteration of a CFTR gene and generation of cells and animal models.

Abstract: A component comprised of a substrate and a multilayer cap. In one example, the inner cap layer may be a material that is typically not considered to be suitable for use with the substrate. In another example, the substrate may be provided with at least two different cap layers to gain the benefits of each cap layer.

Abstract: The present invention is related to methods and apparatus that can enhance the reliability of a hard drive by providing a built-in error check in the drive. Conventional hard drives can erroneously seek to an incorrect location on a platter of the hard drive. The erroneous seek corrupts the data stream and is difficult to detect and correct. Embodiments of the present invention can detect a logical block address assigned to a portion of the platter of the hard drive and thereby detect when an erroneous seek has occurred. Upon detection of an error, one embodiment of the present invention can further take corrective action to read from the correct portion of the platter.

Abstract: The present invention is related to methods and apparatus that can enhance the reliability of a hard drive by providing a built-in error check in the drive. Conventional hard drives can erroneously seek to an incorrect location on a platter of the hard drive. The erroneous seek corrupts the data stream and is difficult to detect and correct. Embodiments of the present invention can detect a logical block address assigned to a portion of the platter of the hard drive and thereby detect when an erroneous seek has occurred. Upon detection of an error, one embodiment of the present invention can further take corrective action to read from the correct portion of the platter.

Abstract: The present invention is related to methods and apparatus that can enhance the reliability of a hard drive by providing a built-in error check in the drive. Conventional hard drives can erroneously seek to an incorrect location on a platter of the hard drive. The erroneous seek corrupts the data stream and is difficult to detect and correct. Embodiments of the present invention can detect a logical block address assigned to a portion of the platter of the hard drive and thereby detect when an erroneous seek has occurred. Upon detection of an error, one embodiment of the present invention can further take corrective action to read from the correct portion of the platter.

Abstract: A process is provided for the manufacture of titanium compounds and particularly titanium dioxide wherein excess titaniferous bearing material is reacted with dilute sulfuric acid having a concentration of between about 25% and about 60% by weight at a temperature below about 140.degree. C. Thereafter, the titanium sulphate may be recovered or processed to provide titanium dioxide hydrate accompanied by recycling the spent acid for reaction with the titaniferous bearing material charged to the process. The titanium hydrate may be calcined to provide titanium dioxide pigment.

Abstract: A process is provided for the manufacture of titanium dioxide pigment wherein excess ilmenite ore is reacted with dilute sulfuric acid having a concentration of between about 25% and about 60% by weight and in preferably at least two stages wherein the first stage is maintained at a temperature up to about 140.degree. C. and the second stage is conducted at a lower temperature (than the first stage) which is below about 100.degree. C. to provide a salt solution of titanium and iron. Thereafter, the titanium is hydrolyzed to provide titanium dioxide hydrate accompanied by recycling the spent acid from the hydrolysis for reaction with the ilmenite ore charged to the process. The titanium hydrate is calcined to provide titanium dioxide pigment.

Abstract: Process of extracting titanium values from titaniferous bearing material by circulating a reaction mixture containing titanium values in an agitation column located within a reaction vessel in a direction countercurrent to the flow of the reaction mixture in the annular space located between the agitation column and the inner reaction vessel wall, said circulation being done in a manner to maintain the titaniferous bearing material in a continuous turbulent suspension flow in the agitation column and discharging the reaction mixture from the reaction vessel and recovering the extracted titanium values.

Abstract: Magnesium oxide is chlorinated in molten impure magnesium chlorine with chlorine gas by adding ferrous chloride to magnesium chloride brine, drying the brine, adding a mixture of calcined petroleum coke and charcoal to the dried brine, melting the product and chlorinating the formed melt. Ferrous chloride is added in amounts sufficient to provide from about 1.0% to 2.2% by weight of iron in the dried product. A highly reactive carbon source is added in amounts of from about 0.8 to 2.3% by weight and a carbon source that is less reactive than the highly reactive carbon source is added in amounts ranging from about 0.8 to 2.3% by weight of dried brine. Iron levels in the magnesium chloride melt may be adjusted upwardly by addition of a mixture of iron oxide and charcoal.A melt cell characterized by side entry electrodes disposed at angles from 40.degree. to 50.degree., an arched roof configuration, and an improved electrode refractory and ceramic sleeve construction is used to chlorinate the magnesium.