Patents by Inventor Brian R. Kovacevich

Brian R. Kovacevich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL RABBIT ANTIBODY HUMANIZATION METHODS AND HUMANIZED RABBIT ANTIBODIES
    Publication number: 20090238825
    Abstract: The present invention is directed to novel and improved methods for humanizing rabbit heavy and light variable regions. The resulting humanized rabbit heavy and light chains and antibodies and antibody fragments containing are well suited for use in immunotherapy and immunodiagnosis as they retain the antigen binding affinity of the parent antibody and based on their very high level of sequence identity to human antibody sequences should be essentially non-immunogenic in humans. The invention exemplifies the protocol for the manufacture of therapeutic humanized anti-human TNF-alpha and anti-human IL-6 antibodies.
    Type: Application
    Filed: March 6, 2009
    Publication date: September 24, 2009
    Inventors: Brian R. Kovacevich, John Latham
  • Novel Rabbit Antibody Humanization Methods and Humanized Rabbit Antibodies
    Publication number: 20090104187
    Abstract: The present invention is directed to novel and improved methods for humanizing rabbit heavy and light variable regions. The resulting humanized rabbit heavy and light chains and antibodies and antibody fragments containing are well suited for use in immunotherapy and immunodiagnosis as they retain the antigen binding affinity of the parent antibody and based on their very high level of sequence identity to human antibody sequences should be essentially non-immunogenic in humans. The invention exemplifies the protocol for the manufacture of therapeutic humanized anti-human TNF-alpha and anti-human IL-6 antibodies.
    Type: Application
    Filed: May 21, 2008
    Publication date: April 23, 2009
    Applicant: Alder Biopharmaceuticals, Inc.
    Inventors: Brian R. Kovacevich, John Latham
  • Recombinant DNA encoding a desulfurization biocatalyst
    Patent number: 5879914
    Abstract: This invention relates to recombinant DNA molecule containing a gene or genes which encode a biocatalyst capable of desulfurizing a fossil fuel which contains organic sulfur molecules. For example, the present invention encompasses a recombinant DNA molecule containing a gene or genes of a strain of Rhodococcus rhodochrous.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: March 9, 1999
    Assignee: Energy BioSystems Corporation
    Inventors: John Rambosek, Chris S. Piddington, Brian R. Kovacevich, Kevin D. Young, Sylvia A. Denome
  • Recombinant DNA encoding a desulfurization biocatalyst
    Patent number: 5578478
    Abstract: This invention relates to a recombinant DNA molecule containing a gene or genes which encode a biocatalyst capable of desulfurizing a fossil fuel which contains organic sulfur molecules. For example, the present invention encompasses a recombinant DNA molecule containing a gene or genes of a strain of Rhodococcus rhodochrous.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: November 26, 1996
    Assignee: Energy BioSystems Corporation
    Inventors: John Rambosek, Chris S. Piddington, Brian R. Kovacevich, Kevin D. Young, Sylvia A. Denome
  • Recombinant DNA encoding a desulfurization biocatalyst
    Patent number: 5356801
    Abstract: This invention relates to a recombinant DNA molecule containing a gene or genes which encode a biocatalyst capable of desulfurizing a fossil fuel which contains organic sulfur molecules. For example, the present invention encompasses a recombinant DNA molecule containing a gene or genes of a strain of Rhodococcus rhodochrous.
    Type: Grant
    Filed: July 9, 1993
    Date of Patent: October 18, 1994
    Assignee: Energy BioSystems Corporation
    Inventors: John Rambosek, Chris S. Piddington, Brian R. Kovacevich, Kevin D. Young, Sylvia A. Denome