Patents by Inventor Brian R. MacDonald

Brian R. MacDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of increasing platelet and hematopoietic stem cell production
    Patent number: 8283313
    Abstract: A method of increasing hematopoietic stem cell production is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier are also disclosed.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: October 9, 2012
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Brian R. MacDonald, Kenneth Kaushansky
  • Methods of increasing platelet and hematopoietic stem cell production
    Patent number: 8067367
    Abstract: A method of increasing hematopoietic stem cell production is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier are also disclosed.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: November 29, 2011
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Brian R. MacDonald, Kenneth Kaushansky
  • METHODS OF INCREASING PLATELET AND HEMATOPOIETIC STEM CELL PRODUCTION
    Publication number: 20110288019
    Abstract: A method of increasing hematopoietic stem cell production is disclosed. The method includes administering a TPO mimetic compound to a subject. Pharmaceutical compositions including a TPO mimetic compound and a pharmaceutically acceptable carrier are also disclosed.
    Type: Application
    Filed: June 20, 2011
    Publication date: November 24, 2011
    Applicant: Janssen Pharmaceutica, N.V.
    Inventors: Brian R. MacDonald, Kenneth Kaushansky
  • Peptides and compounds that bind to a receptor
    Patent number: 7723295
    Abstract: Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
    Type: Grant
    Filed: August 9, 2005
    Date of Patent: May 25, 2010
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Brian R. MacDonald, Jeffery Kenneth Weis, Edward John Yurkow
  • TPO peptide compounds for treatment of anemia
    Patent number: 7615533
    Abstract: Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: November 10, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Edward J. Yurkow, Brian R. MacDonald, Jeffery K. Weis
  • Peptides and compounds that bind to a receptor
    Patent number: 7576056
    Abstract: Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: August 18, 2009
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Brian R. MacDonald, Jeffery Kenneth Weis, Edward John Yurkow
  • Use of TPO peptide compounds and pharmaceutical compostions in the treatment of anemia
    Publication number: 20080119384
    Abstract: Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
    Type: Application
    Filed: February 14, 2006
    Publication date: May 22, 2008
    Inventors: Edward J. Yurkow, Brian R. MacDonald, Jeffery K. Weis
  • Method for minimizing and containing ischemic and reperfusion injury
    Patent number: 5455229
    Abstract: The present invention is a method for minimizing and containing injury caused when tissue is subject to ischemia and reperfusion. The method comprises administering certain derivatized tripeptide arginal compounds concurent with, or immediately after, reestablishing blood flow to the ischemic tissue. The method is particularly useful for minimizing and containing damage to the heart during evolving myocardial infarction.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: October 3, 1995
    Assignee: Eli Lilly and Company
    Inventors: Richard A. Hahn, Brian R. MacDonald, Robert T. Shuman, Gerald F. Smith