Abstract: Neuronal damage is detected by providing a biological sample derived from the subject, detecting in the sample the presence of a neurofilament subunits or their breakdown products, and correlating the presence and level of the neurofilament subunits and their breakdown products detected with the degree of neuronal injury.

Abstract: Methods for detecting a cell damage relate to the discovery that proteases are selectively activated in subjects suffering from nervous system damage compared to samples from healthy subjects. Breakdown products reflecting activation of proteases that degrade spectrin are produced. A cell injury is detected by providing a biological sample derived from the subject; detecting in the sample the presence of these breakdown products generated by multiple proteases, and correlating the presence of these breakdown products with the presence or type of cell damage.

Abstract: Neuronal damage is detected by providing a biological sample derived from the subject, detecting in the sample the presence of a neurofilament subunits or their breakdown products, and correlating the presence and level of the neurofilament subunits and their breakdown products detected with the degree of neuronal injury.

Abstract: A multiple compartment package having a connecting bridge with a frangible internal barrier is made from two composite or thermoplastic sheets or webs welded together to form the front and back walls of the package, and the central bridge portion is defined by one or more partitions spanning the short distance between the webs. In the preferred embodiment, multiple partitions form a plurality of parallel compartment strips to create an obstruction to penetration of substances from one packet to the other. One process for making the invention uses a comb-shaped mask and a thermoplastic insert strip interwoven between the tines of the comb. The tines are extended down between the welding heads of the packaging machine, preventing welding from taking place between the thermoplastic sheets wherever the comb mash is, with the result that the welding occurs between the strip and an alternating one of the side webs creating a zig-zag pattern that forms the vacant barrier compartments.

Abstract: A disposable container for application of paints, medicaments and coatings having a compressible hollow body with a closed end and a membrane sealed open end, and a stationary applicator housing fitted on the membrane sealed open end so that when the hollow body containing liquid is compressed, the membrane is punctured or fractured and the liquid is supplied to the applicator.

Abstract: This relates to the sterile packaging of sterile products. A suitable thermoplastic film tube is formed by an extrusion process wherein the resultant tube is initially sterile internally and externally. The shape of the tube is maintained by a gas supplied under pressure, which gas is maintained in a sterile condition. The resultant tube portions, containers or pouches are filled utilizing filling equipment which is disposed within a housing of the sterile gas supply apparatus and is maintained externally in a sterile state by a suitable heater or other external sterilization methods. A sterile product is delivered from a sterile kettle or the like through a conduit to the filling equipment. The conduit and the filling equipment may be internally sterilized by circulating a suitable chemical sterilizing liquid therethrough as an initial part of the product packaging operation.

Abstract: This relates to a fingernail polish cartridge and dispenser. This will be provided as a sealed unit which may be readily placed in a reusable handpiece and wherein there is associated with a cartridge containing the polish a brush attachment and a plunger. When the brush attachment is moved into the cartridge by way of the handpiece, it will automatically open one end of the cartridge, that end being closed by a separately formed plug which has a sealed fit therein. Then a plunger is utilized to displace a removable panel at the opposite end of the cartidge followed by that removable panel seating on a piston and being moved into the cartridge by further movement of the plunger so as to force the liquid nail polish into the brush attachment.

Abstract: A multiple-compartment package wherein a suitable web or webs having barrier properties for active chemicals is utilized to form a pouch-like multiple-compartment container. The container has the compartments thereof separated by rupturable barrier seals. However, the seals between adjacent compartments do not have the barrier properties of the webs per se from which the package is formed. In order to restrict mixing of migrating chemicals, one or more empty compartments are disposed between those compartments containing the products which are to be mixed.