Abstract: A drill guide arm for providing guidance for placement of a bone tunnel, while protecting against trauma. The guide arm includes a first arm at a proximal end connected at an angle to a second arm, the second arm extending to a distal end. The angle can be within the range of 80°-110°. The second arm extends along a first axis. The guide arm also includes a distal tip extending at a second angle from the second arm at the distal end, and an indicator feature extending from the distal tip toward the first arm. The indicator feature extends along a second axis, the second axis being substantially parallel to the first axis. The guide arm can also include a shield feature of the distal tip. The shield feature has a width wider than the remainder of the distal tip.

Abstract: A drill guide arm for providing guidance for placement of a bone tunnel, while protecting against trauma. The guide arm includes a first arm at a proximal end connected at an angle to a second arm, the second arm extending to a distal end. The angle can be within the range of 80°-110°. The second arm extends along a first axis. The guide arm also includes a distal tip extending at a second angle from the second arm at the distal end, and an indicator feature extending from the distal tip toward the first arm. The indicator feature extends along a second axis, the second axis being substantially parallel to the first axis. The guide arm can also include a shield feature of the distal tip. The shield feature has a width wider than the remainder of the distal tip.

Abstract: A device and system for inserting and impacting bone dowel allografts or bone chips into a bone tunnel. The surgical impacting system includes a surgical tamp having a proximal end and a distal end with an elongated shaft extending therebetween. The surgical tamp has an inner channel extending therethrough from the proximal end to the distal end. The distal end of the surgical tamp can have a distal tip. The surgical tamp may have a handle at the proximal end or a proximal tip at the proximal end. The surgical tamp may also have one or more slots extending through the exterior surface of the elongated shaft and into the inner channel. The surgical tamp can be configured for insertion into a delivery tube. The delivery tube serves the purpose of containing a bone dowel or bone chips therein for smooth insertion into the joint.

Abstract: A drill guide arm for providing guidance for placement of a bone tunnel, while protecting against trauma. The guide arm includes a first arm at a proximal end connected at an angle to a second arm, the second arm extending to a distal end. The angle can be within the range of 80°-110°. The second arm extends along a first axis. The guide arm also includes a distal tip extending at a second angle from the second arm at the distal end, and an indicator feature extending from the distal tip toward the first arm. The indicator feature extends along a second axis, the second axis being substantially parallel to the first axis. The guide arm can also include a shield feature of the distal tip. The shield feature has a width wider than the remainder of the distal tip.

Abstract: Methods and systems for designing the sequences of multiple nucleic acid strands intended to hybridize in solution via a prescribed reaction pathway are described. Sequence design is formulated as a multistate optimization problem using a set of target test tubes containing different subsets of the strands to represent reactant, intermediate, and product states of the system. Each target test tube contains a set of desired “on-target” complexes, each with a target secondary structure and target concentration, and a set of undesired “off-target” complexes, each with vanishing target concentration. Optimization of the equilibrium ensemble properties of the target test tubes may implement both a positive design paradigm, explicitly designing for on-pathway states, and a negative design paradigm, explicitly designing against off-pathway states.

Abstract: Described is a system and process for designing the equilibrium base-pairing properties of a test tube of interacting nucleic acid strands. A target test tube is specified as a set of desired ‘on-target’ complexes, each with a target secondary structure and target concentration, and a set of undesired ‘off-target’ complexes, each with vanishing target concentration. Sequence design is performed by optimizing the test tube ensemble defect, corresponding to the concentration of incorrectly paired nucleotides at equilibrium evaluated over the ensemble of the test tube.

Abstract: Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondary structure is decomposed into a binary tree and candidate mutations are evaluated on leaf nodes of the tree. During a process of leaf optimization, defect-weighted mutation sampling is used to select each candidate mutation position with a probability proportional to its contribution to an ensemble defect of the leaf. Subsequences of the tree are then merged, moving up the tree until a final nucleotide sequence of interest is determined that has the target secondary structure at equilibrium.

Abstract: Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondary structure is decomposed into a binary tree and candidate mutations are evaluated on leaf nodes of the tree. During a process of leaf optimization, defect-weighted mutation sampling is used to select each candidate mutation position with a probability proportional to its contribution to an ensemble defect of the leaf. Subsequences of the tree are then merged, moving up the tree until a final nucleotide sequence of interest is determined that has the target secondary structure at equilibrium.