Patents by Inventor Brian Regna
Brian Regna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250253066Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: April 21, 2025Publication date: August 7, 2025Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
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Publication number: 20250197238Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 110 Ci, about 15 Ci to about 110 Ci, or about 20 Ci to about 110 Ci of isolated copper-64 and have specific activities of about 50 mCi to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions may comprise bombarding a nickel-64 target with a low-medium energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography and/or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: June 17, 2024Publication date: June 19, 2025Inventors: Brian Regna, Lars Lindskog, Allan Casciola, Lauren Radford, Jeffrey Randick, Shaun Loveless
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Patent number: 12315649Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: June 17, 2024Date of Patent: May 27, 2025Assignee: Curium US LLCInventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
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Patent number: 12288627Abstract: The present disclosure is directed compositions and formulations comprising high levels of copper-64, and process for preparing said compositions and formulations. The present disclosure also relates to methods of administering copper-64 compositions to a patient in need thereof.Type: GrantFiled: June 17, 2024Date of Patent: April 29, 2025Assignee: CURIUM US LLCInventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
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Patent number: 12237092Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: August 28, 2023Date of Patent: February 25, 2025Assignee: Curium US LLCInventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst, Shaun Loveless
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Patent number: 12148542Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: August 28, 2023Date of Patent: November 19, 2024Assignee: CURIUM US LLCInventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20240339235Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: June 17, 2024Publication date: October 10, 2024Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
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Publication number: 20240331889Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: June 4, 2024Publication date: October 3, 2024Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Patent number: 11978569Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: August 28, 2023Date of Patent: May 7, 2024Assignee: Curium US LLCInventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Patent number: 11972874Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: June 22, 2023Date of Patent: April 30, 2024Assignee: CURIUM US LLCInventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20230420152Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: August 28, 2023Publication date: December 28, 2023Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20230411032Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: August 28, 2023Publication date: December 21, 2023Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20230402199Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: August 28, 2023Publication date: December 14, 2023Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20230352203Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: June 22, 2023Publication date: November 2, 2023Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Patent number: 11798701Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: November 23, 2022Date of Patent: October 24, 2023Assignee: Curium US LLCInventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20230081594Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: November 23, 2022Publication date: March 16, 2023Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Patent number: 11581103Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: August 24, 2022Date of Patent: February 14, 2023Assignee: Curium US LLCInventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20220406483Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: August 24, 2022Publication date: December 22, 2022Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Patent number: 11521762Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: GrantFiled: September 3, 2021Date of Patent: December 6, 2022Assignee: CURIUM US LLCInventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
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Publication number: 20220064015Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.Type: ApplicationFiled: September 3, 2021Publication date: March 3, 2022Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst