Patents by Inventor Brian Regna

Brian Regna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12603190
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Grant
    Filed: June 4, 2024
    Date of Patent: April 14, 2026
    Assignee: CURIUM US LLC
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst, Shaun Loveless
  • Publication number: 20260074083
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: November 3, 2025
    Publication date: March 12, 2026
    Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
  • Publication number: 20260074084
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: November 20, 2025
    Publication date: March 12, 2026
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst, Shaun Loveless
  • Publication number: 20250385019
    Abstract: The present disclosure is directed compositions and formulations comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci or greater of copper-64 and have specific activities up to about 3850 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: June 18, 2025
    Publication date: December 18, 2025
    Inventors: David Pipes, William Uhland, Brian Regna, Craig Brunkhorst
  • Publication number: 20250368528
    Abstract: The present invention relates to novel compositions comprising high levels of copper-64 (e.g., high radionuclidic purity, high activity, and/or high specific activity), and processes for preparing said compositions. The compositions may comprise from about 2 Ci to about 120 Ci, about 15 Ci to about 120 Ci, about 20 Ci to about 120 Ci, about 30 Ci to about 120 Ci, about 40 Ci to about 110 Ci, or about 50 Ci to about 120 Ci of isolated copper-64 and/or have specific activities of about 10 mCi to about 3850 mCi copper-64 per microgram of copper. The processes for preparing said compositions may comprise bombarding a nickel-64 target with a low-medium energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography and/or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: June 18, 2025
    Publication date: December 4, 2025
    Inventors: Brian Regna, Lars Lindskog, Allan Casciola, Jeffrey Randick
  • Patent number: 12462943
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Grant
    Filed: April 21, 2025
    Date of Patent: November 4, 2025
    Assignee: CURIUM US LLC
    Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
  • Publication number: 20250273354
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: May 1, 2025
    Publication date: August 28, 2025
    Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
  • Publication number: 20250253066
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: April 21, 2025
    Publication date: August 7, 2025
    Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
  • Publication number: 20250197238
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 110 Ci, about 15 Ci to about 110 Ci, or about 20 Ci to about 110 Ci of isolated copper-64 and have specific activities of about 50 mCi to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions may comprise bombarding a nickel-64 target with a low-medium energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography and/or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: June 17, 2024
    Publication date: June 19, 2025
    Inventors: Brian Regna, Lars Lindskog, Allan Casciola, Lauren Radford, Jeffrey Randick, Shaun Loveless
  • Patent number: 12315649
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Grant
    Filed: June 17, 2024
    Date of Patent: May 27, 2025
    Assignee: Curium US LLC
    Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
  • Patent number: 12288627
    Abstract: The present disclosure is directed compositions and formulations comprising high levels of copper-64, and process for preparing said compositions and formulations. The present disclosure also relates to methods of administering copper-64 compositions to a patient in need thereof.
    Type: Grant
    Filed: June 17, 2024
    Date of Patent: April 29, 2025
    Assignee: CURIUM US LLC
    Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
  • Patent number: 12237092
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Grant
    Filed: August 28, 2023
    Date of Patent: February 25, 2025
    Assignee: Curium US LLC
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst, Shaun Loveless
  • Patent number: 12148542
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Grant
    Filed: August 28, 2023
    Date of Patent: November 19, 2024
    Assignee: CURIUM US LLC
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
  • Publication number: 20240339235
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: June 17, 2024
    Publication date: October 10, 2024
    Inventors: Brian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
  • Publication number: 20240331889
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: June 4, 2024
    Publication date: October 3, 2024
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
  • Patent number: 11978569
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Grant
    Filed: August 28, 2023
    Date of Patent: May 7, 2024
    Assignee: Curium US LLC
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
  • Patent number: 11972874
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Grant
    Filed: June 22, 2023
    Date of Patent: April 30, 2024
    Assignee: CURIUM US LLC
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
  • Publication number: 20230420152
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: August 28, 2023
    Publication date: December 28, 2023
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
  • Publication number: 20230411032
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: August 28, 2023
    Publication date: December 21, 2023
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst
  • Publication number: 20230402199
    Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
    Type: Application
    Filed: August 28, 2023
    Publication date: December 14, 2023
    Inventors: David Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst