Abstract: A pipe connection (101a, 101b) for providing a connection to a pipe, the pipe connection comprising: a sleeve (103) which receives a pipe and has a seat (109); a first sealing or gripping element (111) which is disposed adjacent the seat; an intermediate member (115) which is disposed adjacent the first sealing or gripping element; a second sealing or gripping element (123) which is disposed adjacent the intermediate member; an end member (131) which is disposed adjacent the second sealing or gripping element; at least one fixing (159) which engages the end member and is configured to displace the same axially inwardly relative to the sleeve on torquing; and at least one support (151, 153) which is disposed between one of the sleeve (103) and the intermediate member (115) or the intermediate member (115) and the end member (131), wherein the at least one support is configured to maintain the sleeve and the intermediate member or the intermediate member and the end member with a predetermined spaced relation u

Abstract: A pipe connection (101a, 101b) for providing a connection to a pipe, the pipe connection comprising: a sleeve (103) which receives a pipe and has a seat (109); a first sealing or gripping element (111) which is disposed adjacent the seat; an intermediate member (115) which is disposed adjacent the first sealing or gripping element; a second sealing or gripping element (123) which is disposed adjacent the intermediate member; an end member (131) which is disposed adjacent the second sealing or gripping element; at least one fixing (159) which engages the end member and is configured to displace the same axially inwardly relative to the sleeve on torquing; and at least one support (151, 153) which is disposed between one of the sleeve (103) and the intermediate member (115) or the intermediate member (115) and the end member (131), wherein the at least one support is configured to maintain the sleeve and the intermediate member or the intermediate member and the end member with a predetermined spaced relation u

Abstract: Methods and compositions are disclosed for selectively decreasing protein levels in a central nervous system, meningial, immune system, blood, or muscle cell by administrating a pharmacological agent. In particular, methods and compositions that interfere with SOD-1 protein synthesis or stability, and decrease cellular levels of the protein are disclosed.

Abstract: A pipe coupling device (2) for joining the ends of two pipes is disclosed. The pipe coupling device (2) includes a sleeve (4) configured to receive an end of a pipe and having an annular first abutment surface (6); a compression member (12) having an annular second abutment surface (10); a sealing and gripping assembly (8) for sealing against and gripping the pipe; and threaded fasteners for drawing the compression member (12) and the sleeve (4) axially together so as to compress the sealing and gripping assembly (8) against the pipe. The sealing and gripping assembly (8) includes a sealing member (14) and a gripping device. The gripping device may include an annular carrier (16) having an annular recess for retaining a gripping member (18). The gripping surface of the gripping member (18) and the annular carrier (16) are adapted for relative axial movement wherein the gripping member (18) may be moved into tighter contact with the pipe.

Abstract: A pipe coupling device (2) is disclosed. The pipe coupling device (2) includes a sleeve (4) configured to receive an end of a pipe and having an annular first abutment surface (6); a compression member (12) having an annular second abutment surface (10); a sealing and gripping assembly (8) for sealing against and gripping the pipe; and means for drawing the compression member (12) and the sleeve (4) axially together so as to compress the sealing and gripping assembly (8) against the pipe. The sealing and gripping assembly (8) includes a sealing member (14) and a gripping means. The gripping means may include an annular carrier (16) having an annular recess for retaining a gripping member (18). The gripping surface of the gripping member (18) and the annular carrier (16) are adapted for relative axial movement wherein the gripping member (18) may be moved into tighter contact with the pipe.

Abstract: A pipe coupling for attachment to a pipe includes a sleeve. One end of the sleeve is configured to receive a pipe end. The pipe coupling also includes an annular gasket disposed within the end of the sleeve for encircling the pipe end. The coupling includes a flanged assembly for compressing the annular gasket to form a seal between the pipe and the sleeve. The sleeve and the gasket are configured so as to define a leak path between an axially inner portion of the gasket and the inner surface of the sleeve, whereby pressurized fluid from the pipe may pass along the leak path so as to pressurize a radially outer surface of the gasket and urge the gasket against the compression flange to enhance the seal between the gasket and the sleeve.