Abstract: Data associated with actions performed by workers of an organization is identified from multiple sources associated with the workers or the organization. The identified data is provided as input to a machine learning model that is trained to predict, based on data indicating actions of workers, a benefaction level associated with the workers relative to other workers. One or more outputs are obtained from the machine learning model, which indicate a respective benefaction level for each of the workers. A determination is made of whether the respective benefaction level for a worker satisfies criteria associated with a goal defined by the worker and/or the organization. A database associated with the organization is updated to indicate whether the respective benefaction level for a worker satisfies the criteria associated with the goal defined by the worker and/or the organization.

Abstract: A request for one or more digital badges associated with a particular worker of an organization is received. A team of the organization associated with the particular worker during a tenure of the particular worker at the organization is determined. One or more entries of a digital badge database that are associated with the team are identified. The entries indicate one or more digital badges issued to the team based on a benefaction level determined for workers of the team. A set of digital badges issued to the team during a time period that corresponds to the tenure of the particular worker is extracted from the one or more entries. An indication of the extracted set of digital badges is provided in response to the request.

Abstract: A guidance system comprises a first guide configured to be detachably mounted to a first portion of a bone. The first guide has a first axis for alignment with a longitudinal axis of the first portion of the bone. A second guide is mountable on the first guide. The second guide is slidably translatable in a transverse direction relative to the first axis. A third guide is mountable on the second guide. The third guide is selectively positionable along a curved path extending at least part way around the longitudinal axis.

Abstract: A modular structure supports elevated rail segments for delivering electrical power to a moving work machine, such as a hauler at a mining site. Opposite ends of a roadside barrier contain complementary tubular couplers arranged vertically, one having a first diameter supported by an arm and the other having a larger second diameter and a vertical slot. Couplers on adjacent barriers can be mated together concentrically along a central axis. The mated couplers help restrict longitudinal displacement, lateral displacement, slope change, and lateral rotation between adjacent barriers during placement. One barrier may be used as a temporary alignment structure to position barriers spaced alternatingly along a haul route for the work machine.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A modular structure supports elevated rail segments for delivering electrical power to a moving work machine, such as a hauler at a mining site. Opposite ends of a roadside barrier contain complementary tubular couplers arranged vertically, one having a first diameter supported by an arm and the other having a larger second diameter and a vertical slot. Couplers on adjacent barriers can be mated together concentrically along a central axis. The mated couplers help restrict longitudinal displacement, lateral displacement, slope change, and lateral rotation between adjacent barriers during placement. One barrier may be used as a temporary alignment structure to position barriers spaced alternatingly along a haul route for the work machine.

Abstract: An instrument for use in cartilage removal comprises an elongate body having a first end and a longitudinal axis having a longitudinal direction. A cartilage removal portion is coupled to the elongate body at the first end. The cartilage removal portion includes a plurality of serrated blades substantially perpendicular to the longitudinal axis and adapted for removing material while moving in the longitudinal direction. Each serrated blade has a centroid located along the longitudinal axis.

Abstract: A method of determining whether a first playback device is to rejoin a group is disclosed. The method comprises playing back, by the first playback device, media content in synchrony with at least a second playback device, wherein the first and second playback devices are playing back the media content as members of a group. While playing back the media content, and after a loss of power at the first playback device, the method comprises stopping, by the first playback device, playback of the media content. After the loss of power, and after a resumption of power to the first playback device the method comprises automatically determining to rejoin the group and joining the first playback device to the group.

Abstract: A guidance system comprises a first guide configured to be detachably mounted to a first portion of a bone. The first guide has a first axis for alignment with a longitudinal axis of the first portion of the bone. A second guide is mountable on the first guide. The second guide is slidably translatable in a transverse direction relative to the first axis. A third guide is mountable on the second guide. The third guide is selectively positionable along a curved path extending at least part way around the longitudinal axis.

Abstract: The disclosure features compositions or systems and uses thereof, comprising a first polynucleotide encoding a target molecule, optionally a second polynucleotide encoding an effector, repressor, or endonuclease molecule; optionally a recognition or cleavage site in the first or second polynucleotide, and optionally a repressor/effector binding site in the first polynucleotide. The compositions or systems of the present disclosure can increase the level and/or activity of the target molecule in desired cells and/or microenvironments while suppressing the level and/or activity of the target molecule in off-target cells and/or microenvironments.

Abstract: A stormwater capture and filtration system may include a capture portion including attachment mechanisms, a funnel, various supports, and a filter hanger designed and calculated to capture all water entering a stormwater inlet and directing it toward a bag filter. An adjustable overflow gap is provided between a funnel and filter hanger in order to provide accommodation for overflow, while an anti-backflow skirt on the filter bag resists flushing of captured pollution out of the bag in overflow condition. Components of the filtration system may be adjustable, for example, an adjustable frame, an adjustable funnel, an adjustable hanger, and the like.

Abstract: The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5?ITR-B1-BA-B2-BX-BB-BY-B3-3?ITR wherein: B1 is a bond or comprises: E1A, E1B or E1A-E1B; BA comprises: E2B-L1-L2-L3-E2A-L4; B2 is a bond or comprises: E3; BX is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; BB comprises: L5; BY is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B3 is a bond or comprises: E4; wherein at least one of BX or BY is not a bond, pharmaceutical compositions comprising the same and use of the viruses and compositions in treatment, particularly in the treatment of cancer. The disclosure also extends to plasmids and processes employed to prepare the said viruses.

Abstract: Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.

Abstract: The present disclosure provides a cleaning system and various related apparatus for grooming a pet. The cleaning system can comprise components dedicated to pet grooming or can adapt a surface cleaning apparatus or tools normally used for cleaning floors and upholstery to instead groom a pet. The pet grooming system can include a portable module, a fluid delivery system, and a recovery system. The recovery system can include a recovery pathway, a recovery tank, and a suction source. An enclosure for the suction source eliminates a direct, unobstructed path for soundwaves exiting the enclosure and at least one other opening where air enters or exits the portable module.

Abstract: A pump dispenser has a pump body and a reciprocable plunger with a lock-down mechanism, including internal or external lock formations of the plunger and body, such as thread formations, by which the plunger can be locked down for shipping and released subsequently by a rotational release movement. To supplement security for demanding shipping conditions the dispenser also has a supplementary catch mechanism in which respective catch formations of the plunger and body engage selectively in the locked-down position to inhibit the rotational release movement. The catch formations may have circumferentially-directed surfaces which engage between the underside of a plunger head having a shroud and a nozzle and the top of the body beneath the plunger head. They can be released by resilient deformation of one or more of the catch formations.

Abstract: A central processing unit (CPU) system including a CPU core can include an adaptive cache compressor, which is capable of monitoring a miss profile of a cache. The adaptive cache compressor can compare the miss profile to a miss threshold. Based on this comparison, the adaptive cache compressor can determine whether to enable compression of the cache.

Abstract: An apparatus that includes a scenario interpretation circuit, a scenario analysis circuit, a data analysis circuit, a data source locator circuit, and a data retrieval circuit. The scenario interpretation circuit is structured to interpret time-sequence scenario data. The scenario analysis circuit is structured to extract a scenario element from the time-sequence scenario data. The data analysis circuit is structured to determine, based at least in part on the extracted scenario element, a type of data for inclusion in the generation of time-sequence data corresponding to the scenario data. The data source locator circuit is structured to identify a source of the type of data for inclusion in the generation of the time-sequence data. The data retrieval circuit structured to retrieve data from the identified source. The data provisioning circuit structured to transmit the retrieved data.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: The present disclosure relates to a replication deficient oncolytic viral vector or replication capable group B oncolytic adenovirus selected from the group consisting of Ad11 and enadenotucirev, wherein the virus encodes an antibody or a binding fragment thereof for expression on the surface of a cancer cell, wherein said antibody or binding fragment is specific to a CD3 protein of a T-cell receptor complex (TCR), wherein the virus does not encode a B7 protein or an active fragment thereof, pharmaceutical compositions comprising the same, and use of any one of the same in treatment, particularly in the treatment of cancer.

Abstract: A fluid displacement and pressurization device which provides both a substantial amount of thread engagement as well as provides for single hand control for all operational manipulations including maintaining a set fill volume, rapid filling and displacement, and pressurization and retention of evacuation positioning during balloon depressurization. The device allows for the use of one hand to not only transition the device from micro-movement control to macro-movement control, but also regarding rotating, pushing or pulling the handle of the plunger.