Patents by Inventor Brian Roberts

Brian Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12150651
    Abstract: A guidance system comprises a first guide configured to be detachably mounted to a first portion of a bone. The first guide has a first axis for alignment with a longitudinal axis of the first portion of the bone. A second guide is mountable on the first guide. The second guide is slidably translatable in a transverse direction relative to the first axis. A third guide is mountable on the second guide. The third guide is selectively positionable along a curved path extending at least part way around the longitudinal axis.
    Type: Grant
    Filed: July 28, 2022
    Date of Patent: November 26, 2024
    Assignee: WRIGHT MEDICAL TECHNOLOGY, INC.
    Inventors: Joseph Ryan Woodard, Brian Robert Thoren
  • Publication number: 20240384277
    Abstract: The disclosure features compositions or systems and uses thereof, comprising a first polynucleotide encoding a target molecule, optionally a second polynucleotide encoding an effector, repressor, or endonuclease molecule; optionally a recognition or cleavage site in the first or second polynucleotide, and optionally a repressor/effector binding site in the first polynucleotide. The compositions or systems of the present disclosure can increase the level and/or activity of the target molecule in desired cells and/or microenvironments while suppressing the level and/or activity of the target molecule in off-target cells and/or microenvironments.
    Type: Application
    Filed: June 14, 2022
    Publication date: November 21, 2024
    Inventors: Ruchi Jain, Brian Robert Fritz, Mihir Metkar
  • Publication number: 20240344318
    Abstract: A stormwater capture and filtration system may include a capture portion including attachment mechanisms, a funnel, various supports, and a filter hanger designed and calculated to capture all water entering a stormwater inlet and directing it toward a bag filter. An adjustable overflow gap is provided between a funnel and filter hanger in order to provide accommodation for overflow, while an anti-backflow skirt on the filter bag resists flushing of captured pollution out of the bag in overflow condition. Components of the filtration system may be adjustable, for example, an adjustable frame, an adjustable funnel, an adjustable hanger, and the like.
    Type: Application
    Filed: May 23, 2024
    Publication date: October 17, 2024
    Inventors: Brian Robert Deurloo, Thomas James Stypula
  • Publication number: 20240325472
    Abstract: The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5?ITR-B1-BA-B2-BX-BB-BY-B3-3?ITR wherein: B1 is a bond or comprises: E1A, E1B or E1A-E1B; BA comprises: E2B-L1-L2-L3-E2A-L4; B2 is a bond or comprises: E3; BX is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; BB comprises: L5; BY is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B3 is a bond or comprises: E4; wherein at least one of BX or BY is not a bond, pharmaceutical compositions comprising the same and use of the viruses and compositions in treatment, particularly in the treatment of cancer. The disclosure also extends to plasmids and processes employed to prepare the said viruses.
    Type: Application
    Filed: February 21, 2024
    Publication date: October 3, 2024
    Inventors: Brian Robert CHAMPION, Alice Claire Noel BROWN, Kerry David FISHER, Tamara NICOLSON
  • Publication number: 20240307448
    Abstract: Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.
    Type: Application
    Filed: April 2, 2024
    Publication date: September 19, 2024
    Inventors: Dina Schneider, Boro Dropulic, Brian Robert Webster
  • Publication number: 20240306602
    Abstract: The present disclosure provides a cleaning system and various related apparatus for grooming a pet. The cleaning system can comprise components dedicated to pet grooming or can adapt a surface cleaning apparatus or tools normally used for cleaning floors and upholstery to instead groom a pet. The pet grooming system can include a portable module, a fluid delivery system, and a recovery system. The recovery system can include a recovery pathway, a recovery tank, and a suction source. An enclosure for the suction source eliminates a direct, unobstructed path for soundwaves exiting the enclosure and at least one other opening where air enters or exits the portable module.
    Type: Application
    Filed: May 29, 2024
    Publication date: September 19, 2024
    Inventors: Jeremy W. Hoffmann, Brian Robert Dexter
  • Patent number: 12064777
    Abstract: A pump dispenser has a pump body and a reciprocable plunger with a lock-down mechanism, including internal or external lock formations of the plunger and body, such as thread formations, by which the plunger can be locked down for shipping and released subsequently by a rotational release movement. To supplement security for demanding shipping conditions the dispenser also has a supplementary catch mechanism in which respective catch formations of the plunger and body engage selectively in the locked-down position to inhibit the rotational release movement. The catch formations may have circumferentially-directed surfaces which engage between the underside of a plunger head having a shroud and a nozzle and the top of the body beneath the plunger head. They can be released by resilient deformation of one or more of the catch formations.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: August 20, 2024
    Assignee: RIEKE PACKAGING SYSTEMS LIMITED
    Inventors: Simon Christopher Knight, Brian Robert Law, Thomas P. Kasting
  • Patent number: 12066935
    Abstract: A central processing unit (CPU) system including a CPU core can include an adaptive cache compressor, which is capable of monitoring a miss profile of a cache. The adaptive cache compressor can compare the miss profile to a miss threshold. Based on this comparison, the adaptive cache compressor can determine whether to enable compression of the cache.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: August 20, 2024
    Assignee: International Business Machines Corporation
    Inventors: Bulent Abali, Alper Buyuktosunoglu, Brian Robert Prasky, Deanna Postles Dunn Berger
  • Publication number: 20240257000
    Abstract: An apparatus that includes a scenario interpretation circuit, a scenario analysis circuit, a data analysis circuit, a data source locator circuit, and a data retrieval circuit. The scenario interpretation circuit is structured to interpret time-sequence scenario data. The scenario analysis circuit is structured to extract a scenario element from the time-sequence scenario data. The data analysis circuit is structured to determine, based at least in part on the extracted scenario element, a type of data for inclusion in the generation of time-sequence data corresponding to the scenario data. The data source locator circuit is structured to identify a source of the type of data for inclusion in the generation of the time-sequence data. The data retrieval circuit structured to retrieve data from the identified source. The data provisioning circuit structured to transmit the retrieved data.
    Type: Application
    Filed: January 24, 2023
    Publication date: August 1, 2024
    Inventors: David Henry Wayne, Brian Robert Muras, Keith Alan Briggs, Alexander L. Krowitz
  • Patent number: 12049513
    Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 30, 2024
    Assignee: AKAMIS BIO LIMITED
    Inventors: Brian Robert Champion, Alice Claire Noel Bromley, Joshua David Freedman, Kerry David Fisher, Leonard William Seymour
  • Publication number: 20240247061
    Abstract: The present disclosure relates to a replication deficient oncolytic viral vector or replication capable group B oncolytic adenovirus selected from the group consisting of Ad11 and enadenotucirev, wherein the virus encodes an antibody or a binding fragment thereof for expression on the surface of a cancer cell, wherein said antibody or binding fragment is specific to a CD3 protein of a T-cell receptor complex (TCR), wherein the virus does not encode a B7 protein or an active fragment thereof, pharmaceutical compositions comprising the same, and use of any one of the same in treatment, particularly in the treatment of cancer.
    Type: Application
    Filed: November 27, 2023
    Publication date: July 25, 2024
    Inventors: Brian Robert CHAMPION, Alice Claire Noel BROWN
  • Publication number: 20240238567
    Abstract: A fluid displacement and pressurization device which provides both a substantial amount of thread engagement as well as provides for single hand control for all operational manipulations including maintaining a set fill volume, rapid filling and displacement, and pressurization and retention of evacuation positioning during balloon depressurization. The device allows for the use of one hand to not only transition the device from micro-movement control to macro-movement control, but also regarding rotating, pushing or pulling the handle of the plunger.
    Type: Application
    Filed: March 27, 2024
    Publication date: July 18, 2024
    Inventors: Jonathan Collins, Rowland W. Kanner, Brian Roberts
  • Patent number: 12034095
    Abstract: Embodiments of the invention describe apparatuses, optical systems, and methods related to utilizing optical cladding layers. According to one embodiment, a hybrid optical device includes a silicon semiconductor layer and a III-V semiconductor layer having an overlapping region, wherein a majority of a field of an optical mode in the overlapping region is to be contained in the III-V semiconductor layer. A cladding region between the silicon semiconductor layer and the III-V semiconductor layer has a spatial property to substantially confine the optical mode to the III-V semiconductor layer and enable heat dissipation through the silicon semiconductor layer.
    Type: Grant
    Filed: August 17, 2022
    Date of Patent: July 9, 2024
    Assignee: OpenLight Photonics, Inc.
    Inventors: Erik Johan Norberg, Anand Ramaswamy, Brian Robert Koch
  • Patent number: 12022800
    Abstract: The present disclosure provides a cleaning system and various related apparatus for grooming a pet. The cleaning system can comprise components dedicated to pet grooming or can adapt a surface cleaning apparatus or tools normally used for cleaning floors and upholstery to instead groom a pet. The cleaning system can include two supply tanks, and a supply valve controlling the flow of cleaning solution out of one of the tanks.
    Type: Grant
    Filed: December 20, 2022
    Date of Patent: July 2, 2024
    Assignee: BISSELL Inc.
    Inventors: Jeremy W. Hoffmann, Brian Robert Dexter
  • Patent number: 12014182
    Abstract: Embodiments include a hierarchical metadata prediction system that includes a first line-based predictor having a first line for storage of metadata entries, and a second line-based predictor configured to store metadata entries from the first line-based predictor. The second line-based predictor has a second line, the second line including a plurality of containers, the plurality of containers including at least a first set of containers having a first size and a second set of containers having a second size. The system also includes a processing device configured to transfer one or more metadata entries between the first line-based predictor and the second-line based predictor. Embodiments also include a computer-implemented method and a computer program product.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: June 18, 2024
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Brian Robert Prasky, James Bonanno, Adam Benjamin Collura
  • Publication number: 20240180983
    Abstract: A group B adenovirus comprising a sequence of formula 5?ITR—B1-BA-B2-BX-BB-BY-B3-3?ITR, wherein: BY comprises a sequence -G1-G2n-G3m-G4p-G5q. G1 is a first transgene. G2 is a second transgene. G3 is a third transgene. G4 is a fourth transgene. G5 is a fifth transgene and IL-15 is encoded as a transgene in at least one of said locations, and characterised in that BY also encodes a polypeptide comprising the sushi domain of IL-15R alpha.
    Type: Application
    Filed: February 14, 2022
    Publication date: June 6, 2024
    Inventors: Brian Robert CHAMPION, Manuela ZONCA
  • Publication number: 20240174738
    Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
    Type: Application
    Filed: July 5, 2023
    Publication date: May 30, 2024
    Inventors: Brian Robert Kovacevich, Leon F. Garcia-Martinez, Katie Olson Anderson, Benjamin H. Dutzar, Jens J. Billgren, John A. Latham, Danielle M. Mitchell, Patricia Dianne McNeill, Nicole M. Janson, Maria-Cristina Loomis
  • Patent number: 11980729
    Abstract: A fluid displacement and pressurization device which provides both a substantial amount of thread engagement as well as provides for single hand control for all operational manipulations including maintaining a set fill volume, rapid filling and displacement, and pressurization and retention of evacuation positioning during balloon depressurization. The device allows for the use of one hand to not only transition the device from micro-movement control to macro-movement control, but also regarding rotating, pushing or pulling the handle of the plunger.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: May 14, 2024
    Assignee: Atrion Medical Products, Inc.
    Inventors: Jonathan Collins, Rowland Kanner, Brian Roberts
  • Patent number: 11969443
    Abstract: Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: April 30, 2024
    Assignee: LENTIGEN TECHNOLOGY, INC.
    Inventors: Dina Schneider, Boro Dropulic, Brian Robert Webster
  • Patent number: 11970536
    Abstract: The present disclosure relates to a replication deficient oncolytic viral vector or replication capable group B oncolytic adenovirus selected from the group consisting of Ad11 and enadenotucirev, wherein the virus encodes an antibody or a binding fragment thereof for expression on the surface of a cancer cell, wherein said antibody or binding fragment is specific to a CD3 protein of a T-cell receptor complex (TCR), wherein the virus does not encode a B7 protein or an active fragment thereof, pharmaceutical compositions comprising the same, and use of any one of the same in treatment, particularly in the treatment of cancer.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: April 30, 2024
    Assignee: AKAMIS BIO LIMITED
    Inventors: Brian Robert Champion, Alice Claire Noel Brown