Abstract: An input device for a multiple wavelength band optical switch comprising: an optical demultiplexer configured to receive light and disperse the received light along a dispersion axis; and a light director configured to direct light in a first wavelength band to the optical demultiplexer at a first angle of incidence and to direct light in a second wavelength band to the optical demultiplexer at a second angle of incidence, the second angle of incidence being different from the first: wherein the difference between the first and second angles of incidence causes the demultiplexer to output dispersed spectra of light corresponding to the first and second bands such that the dispersed spectrum corresponding to the first band is overlapped along the dispersion axis and separated along a switch axis relative to the dispersed spectrum corresponding to the second wavelength band, the switch axis being perpendicular to the dispersion axis.

Abstract: The present invention relates to a compound of Formula (I): or a stereoisomer, solvate, tautomer or pharmaceutically acceptable salt thereof, wherein X, W1, W2, Y, Z, R1, R2 and R3 are as defined in the disclosure herein, for use in therapy, particularly for use in the treatment of cancer. The present invention also relates to methods of treating cancer comprising the administration of a compound of Formula (I) to a subject in need thereof, and to pharmaceutical compositions and kits comprising such compounds.

Abstract: A removable cover plate assembly may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies.

Abstract: The invention comprises an automated, dynamic cover plate system, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The automated, dynamic cover plate system adjusts the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. The automated, dynamic cover plate system of the present invention is designed to be controlled, either manually or automatically, by the operator of the combine harvester or by a computerized or automated intelligence system.

Abstract: The present invention relates to a compound of Formula (I), or a stereoisomer, solvate, tautomer or pharmaceutically acceptable salt thereof, wherein X, W1, W2, Y, Z, R1, R2 and R3 are as defined in the disclosure herein, for use in therapy, particularly for use in the treatment of cancer. The present invention also relates to methods of treating cancer comprising the administration of a compound of Formula (I) to a subject in need thereof, and to pharmaceutical compositions and kits comprising such compounds.

Abstract: The present invention generally relates to systems, methods and compositions used for the control of gene expression involving sequence targeting, such as genome perturbation or gene-editing, that may use vector systems related to recombinases and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof.

Abstract: The present invention generally relates to systems, methods and compositions used for the control of gene expression involving sequence targeting, such as genome perturbation or gene-editing, that may use vector systems related to recombinases and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof.

Abstract: An optical switching unit comprising: a plurality of arrays of multiple optical waveguides; and a switching structure controllable to direct light received from any of the optical waveguides in a first array of the plurality of arrays to one or more optical waveguides of each other array in the plurality of arrays.

Abstract: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmC) and/or 5-methylcytosine (5meC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC and/or 5meC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g.

Abstract: The present invention relates to a compound of Formula (I), or a stereoisomer, solvate, tautomer or pharmaceutically acceptable salt thereof, wherein X, W1, W2, Y, Z, R1, R2 and R3 are as defined in the disclosure herein, for use in therapy, particularly for use in the treatment of cancer. The present invention also relates to methods of treating cancer comprising the administration of a compound of Formula (I) to a subject in need thereof, and to pharmaceutical compositions and kits comprising such compounds.

Abstract: The present invention generally relates to systems, methods and compositions used for the control of gene expression involving sequence targeting, such as genome perturbation or gene-editing, that may use vector systems related to recombinases and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof.

Abstract: The present invention comprises a removable cover plate assembly, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The cover plate assembly improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.

Abstract: The present invention comprises a removable cover plate assembly, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The cover plate assembly improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.

Abstract: A removable cover plate assembly may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The cover plate assembly improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.

Abstract: An input device for a multiple wavelength band optical switch comprising: an optical demultiplexer configured to receive light and disperse the received light along a dispersion axis; and a light director configured to direct light in a first wavelength band to the optical demultiplexer at a first angle of incidence and to direct light in a second wavelength band to the optical demultiplexer at a second angle of incidence, the second angle of incidence being different from the first; wherein the difference between the first and second angles of incidence causes the demultiplexer to output dispersed spectra of light corresponding to the first and second bands such that the dispersed spectrum corresponding to the first band is overlapped along the dispersion axis and separated along a switch axis relative to the dispersed spectrum corresponding to the second wavelength band, the switch axis being perpendicular to the dispersion axis.

Abstract: An optical switching unit comprising: a plurality of arrays of multiple optical waveguides; and a switching structure controllable to direct light received from any of the optical waveguides in a first array of the plurality of arrays to one or more optical waveguides of each other array in the plurality of arrays.

Abstract: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmC) and/or 5-methylcytosine (5meC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC and/or 5meC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA.

Abstract: The present invention comprises multiple embodiments of an automated, dynamic cover plate system, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The automated, dynamic cover plate system improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. The automated, dynamic cover plate system of the present invention is designed to be controlled, either manually or automatically, by the operator of the combine harvester or by a computerized or automated intelligence system.

Abstract: The present invention comprises multiple embodiments of an automated, dynamic cover plate system, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The automated, dynamic cover plate system improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. The automated, dynamic cover plate system of the present invention is designed to be controlled, either manually or automatically, by the operator of the combine harvester or by a computerized or automated intelligence system.