Abstract: The present invention relates to a compound of Formula (I), or a stereoisomer, solvate, tautomer or pharmaceutically acceptable salt thereof, wherein X, W1, W2, Y, Z, R1, R2 and R3 are as defined in the disclosure herein, for use in therapy, particularly for use in the treatment of cancer. The present invention also relates to methods of treating cancer comprising the administration of a compound of Formula (I) to a subject in need thereof, and to pharmaceutical compositions and kits comprising such compounds.

Abstract: Systems and methods for constructing an itinerary for a user based on articles of multimedia content are disclosed. One computer-implemented method may include: receiving, at the server and from a user device hosting a media streaming platform, an indication of selection by a user of a travel option associated with an aspect featured in an article of multimedia content presented on the media streaming platform; identifying, based on the receiving, a real-world location of the aspect; ascertaining, by the server, contextual information associated with the user; establishing, based on the real-world location of the aspect and the contextual information associated with the user, the itinerary for travel to the aspect; and presenting, subsequent to the establishing, a visual display of the itinerary on the media-streaming platform. Other aspects are described and claimed.

Abstract: Systems and methods for distributing rewards based on user actions performed in association with multimedia content are disclosed. One computer-implemented method may include: receiving, at the server, an indication of a real-world action performed by a user; identifying, by the server, that the real-world action corresponds to a rewards-based action performed in association with an article of multimedia content present on a media-streaming platform, wherein the rewards-based action at least corresponds to visitation to a geographic location associated with an aspect of the article of multimedia content; determining, by the server, whether performance of the rewards-based action necessitates distribution of a reward to the user, ascertaining, subsequent to determining that performance of the rewards-based action does necessitate distribution of the reward to the user, a type of the reward; and distributing, based on the ascertaining, the reward of the ascertained type to the user.

Abstract: Systems and methods for apprising a user of a proximately located aspect-of-interest are disclosed. One method may include: receiving an indication of a geographic location associated with the user; identifying an aspect associated with a multimedia content interest of the user; determining whether the geographic location associated is within a predetermined distance to a known location the aspect associated with the multimedia content interest; transmitting, responsive to determining that the geographic location is within the predetermined distance to the known location, instructions to a user device associated with the user to provide a notification to the user; receiving, at the server, another indication that the user has provided interaction input to the notification; and transmitting additional instructions to another device to perform an action that is based on the interaction input.

Abstract: The present invention generally relates to systems, methods and compositions used for the control of gene expression involving sequence targeting, such as genome perturbation or gene-editing, that may use vector systems related to recombinases and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof.

Abstract: The present invention generally relates to systems, methods and compositions used for the control of gene expression involving sequence targeting, such as genome perturbation or gene-editing, that may use vector systems related to recombinases and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof.

Abstract: An optical switching unit comprising: a plurality of arrays of multiple optical waveguides; and a switching structure controllable to direct light received from any of the optical waveguides in a first array of the plurality of arrays to one or more optical waveguides of each other array in the plurality of arrays.

Abstract: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmC) and/or 5-methylcytosine (5meC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC and/or 5meC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g.

Abstract: The present invention relates to a compound of Formula (I), or a stereoisomer, solvate, tautomer or pharmaceutically acceptable salt thereof, wherein X, W1, W2, Y, Z, R1, R2 and R3 are as defined in the disclosure herein, for use in therapy, particularly for use in the treatment of cancer. The present invention also relates to methods of treating cancer comprising the administration of a compound of Formula (I) to a subject in need thereof, and to pharmaceutical compositions and kits comprising such compounds.

Abstract: The present invention generally relates to systems, methods and compositions used for the control of gene expression involving sequence targeting, such as genome perturbation or gene-editing, that may use vector systems related to recombinases and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof.

Abstract: The present invention comprises a removable cover plate assembly, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The cover plate assembly improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.

Abstract: The present invention comprises a removable cover plate assembly, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The cover plate assembly improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.

Abstract: A removable cover plate assembly may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The cover plate assembly improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.

Abstract: An input device for a multiple wavelength band optical switch comprising: an optical demultiplexer configured to receive light and disperse the received light along a dispersion axis; and a light director configured to direct light in a first wavelength band to the optical demultiplexer at a first angle of incidence and to direct light in a second wavelength band to the optical demultiplexer at a second angle of incidence, the second angle of incidence being different from the first; wherein the difference between the first and second angles of incidence causes the demultiplexer to output dispersed spectra of light corresponding to the first and second bands such that the dispersed spectrum corresponding to the first band is overlapped along the dispersion axis and separated along a switch axis relative to the dispersed spectrum corresponding to the second wavelength band, the switch axis being perpendicular to the dispersion axis.

Abstract: An optical switching unit comprising: a plurality of arrays of multiple optical waveguides; and a switching structure controllable to direct light received from any of the optical waveguides in a first array of the plurality of arrays to one or more optical waveguides of each other array in the plurality of arrays.

Abstract: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmC) and/or 5-methylcytosine (5meC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC and/or 5meC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA.

Abstract: The present invention comprises multiple embodiments of an automated, dynamic cover plate system, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The automated, dynamic cover plate system improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. The automated, dynamic cover plate system of the present invention is designed to be controlled, either manually or automatically, by the operator of the combine harvester or by a computerized or automated intelligence system.

Abstract: The present invention comprises multiple embodiments of an automated, dynamic cover plate system, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The automated, dynamic cover plate system improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. The automated, dynamic cover plate system of the present invention is designed to be controlled, either manually or automatically, by the operator of the combine harvester or by a computerized or automated intelligence system.

Abstract: The invention comprises a method for increasing the harvesting effectiveness of a combine harvester using a removable cover plate assembly, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The method for using the cover plate assembly increases the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.