Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein (e.g., a eukaryotic target protein such as a mammalian target protein or a fungal target protein or a prokaryotic target protein such as a bacterial target protein). These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted protein's activity.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.

Abstract: A handheld vacuum assembly for the capture and collection of small insects that includes a vacuum body defining a suction chamber, a motor operably configured to generate a vacuum downstream in the suction chamber, a funnel member defining a suction channel located downstream of the suction chamber and a suction channel area therein, a valve disposed within the suction channel that is configured to open and close to inhibit or prevent insects from leaving the funnel member, and a filter assembly disposed upstream of the suction channel, downstream of the motor, having a porous membrane member, having a filter cap selectively removably coupled to the porous membrane member and having a plurality of selectively removable strips disposed thereon and each having an adhesive surface oriented in a direction facing the distal tip of the funnel member.

Abstract: A handheld vacuum assembly for the capture and collection of small insects that includes a vacuum body defining a suction chamber, a motor operably configured to generate a vacuum downstream in the suction chamber, a funnel member defining a suction channel located downstream of the suction chamber and a suction channel area therein, a valve disposed within the suction channel that is configured to open and close to inhibit or prevent insects from leaving the funnel member, and a filter assembly disposed upstream of the suction channel, downstream of the motor, having a porous membrane member, having a filter cap selectively removably coupled to the porous membrane member and having a plurality of selectively removable strips disposed thereon and each having an adhesive surface oriented in a direction facing the distal tip of the funnel member.

Abstract: A circuit includes a transistor input pair, a differential input having a comparator input, and a level shifter. The transistor input pair is adapted to be coupled between a voltage supply and a comparator output. The transistor input pair includes a first transistor having a gate and a drain. The drain of the first transistor is coupled to the comparator output. The level shifter is coupled between the transistor input pair and the differential input. The level shifter includes a second transistor having a gate and a source. The gate of the second transistor is coupled to the comparator input. The source of the second transistor is coupled to the gate of the first transistor.

Abstract: A circuit includes a transistor input pair, a differential input having a comparator input, and a level shifter. The transistor input pair is adapted to be coupled between a voltage supply and a comparator output. The transistor input pair includes a first transistor having a gate and a drain. The drain of the first transistor is coupled to the comparator output. The level shifter is coupled between the transistor input pair and the differential input. The level shifter includes a second transistor having a gate and a source. The gate of the second transistor is coupled to the comparator input. The source of the second transistor is coupled to the gate of the first transistor.

Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: An example apparatus for generating real-time director's cuts includes a number of cameras to capture videos of a plurality of participants in a scene. The apparatus also includes a number of microphones to capture audio corresponding to each of the number of participants. The apparatus further includes a role-centric evaluator to receive views-of-participants and a role for each of the participants and rank the views-of-participants based on the roles. Each of the views-of-participants are tagged with one of the participants. The apparatus further includes a view broadcaster to display a highest ranking view-of-participant stream.

Abstract: A medication inventory system may include a medication tray that includes partitions defining compartments and having a tray identifier associated therewith, and each compartment may store a respective medication. The system may include an imaging apparatus, and a processor and an associated memory cooperating with the imaging apparatus to determine the tray identifier of the medication tray, and maintain in the memory a desired respective medication within each compartment based upon the tray identifier. A respective medication image of the medication within each compartment may be obtained and machine learning may be used to determine a medication within each compartment based upon the respective medication image.

Abstract: Intelligence production suffers from inadequate collaboration, poor information sharing, and lack of visibility into a complex production process, resulting in intelligence reports that are not aligned to the user's needs. This exacerbates decision-making problems by preventing critical data from reaching the appropriate staff, which prevents commanders from achieving their desired mission requirements due to incomplete or inadequate information. Using Object-Based Production, Adaptive Process Management, and Entity Management technologies, a new wiki-like capability was created that provides a wiki's ease of use and understanding while addressing weaknesses such as lack of multi-level security, no enforcement of publishing standards, and lack of product currency, providing an intelligence production solution addressing the above needs.

Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.

Abstract: A semiconductor assembly includes a power semiconductor, a housing containing the power semiconductor, and electrically conductive channels. The electrically conductive channels are arranged to direct coolant through the housing. Heat generated by the power semiconductor can therefore be absorbed by the coolant. The electrically conductive channels are also electrically connected with the power semiconductor to form terminals for the power semiconductor.

Abstract: In some examples, a switch comprises first and second drain-extended transistors of a first type, third and fourth drain-extended transistors of a second type, a switch input coupled between drains of the first and third drain-extended transistors, a switch output coupled between drains of the second and fourth drain-extended transistors, and a control input. The control input is coupled to gates of the first and second drain-extended transistors, a first switch coupled to sources of the first and second drain-extended transistors, a second switch coupled between a voltage supply and gates of the third and fourth drain-extended transistors, and a third switch coupled between the voltage supply and sources of the third and fourth drain-extended transistors. The control input comprises a fifth drain-extended transistor coupled between the sources of the third and fourth drain-extended transistors and the gates of the third and fourth drain-extended transistors.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: In some examples, a switch comprises first and second drain-extended transistors of a first type, third and fourth drain-extended transistors of a second type, a switch input coupled between drains of the first and third drain-extended transistors, a switch output coupled between drains of the second and fourth drain-extended transistors, and a control input. The control input is coupled to gates of the first and second drain-extended transistors, a first switch coupled to sources of the first and second drain-extended transistors, a second switch coupled between a voltage supply and gates of the third and fourth drain-extended transistors, and a third switch coupled between the voltage supply and sources of the third and fourth drain-extended transistors. The control input comprises a fifth drain-extended transistor coupled between the sources of the third and fourth drain-extended transistors and the gates of the third and fourth drain-extended transistors.

Abstract: A heat exchanger includes a plurality of tube assemblies. Each tube assembly includes an inner tube extending within an outer tube and configured for the flow of a first fluid therein. The inner tube and the outer tube are sized to facilitate capillary action fluid flow of a second fluid in an annular space between an outer surface of the inner tube and an inner surface of the outer tube, facilitating indirect heat exchange of the second fluid, through the inner tube and indirect heat exchange of the second fluid through the outer tube.

Abstract: A circuit includes a transistor input pair, a differential input having a comparator input, and a level shifter. The transistor input pair is adapted to be coupled between a voltage supply and a comparator output. The transistor input pair includes a first transistor having a gate and a drain. The drain of the first transistor is coupled to the comparator output. The level shifter is coupled between the transistor input pair and the differential input. The level shifter includes a second transistor having a gate and a source. The gate of the second transistor is coupled to the comparator input. The source of the second transistor is coupled to the gate of the first transistor.