Abstract: An apparatus includes a transient voltage suppression (TVS) device configured to be coupled in parallel with a burden resistor. The apparatus also includes a switch configured to couple the TVS device across the burden resistor. The apparatus further includes a comparator configured to detect a peak output voltage provided by a circuit, determine whether the peak output voltage meets or exceeds a threshold, and control the switch based on whether the peak output voltage meets or exceeds the threshold.

Abstract: Systems and methods for a bedside handle system having two-stage laser motion detection and wireless communication alert. The system detects and sends wireless alerts when a patient sits up and when the patient stands up. The system further includes a mobile app for receiving and displaying the alerts.

Abstract: A physiological characteristic monitoring system includes a wearable attachment device, an electronic device, and a physiological characteristic sensor (e.g., a glucose sensor) including a portion that is insertable into subcutaneous tissue of a user to generate sensor signals indicating a physiological characteristic of the user. The electronic device includes a first connector configured to detachably couple to the physiological characteristic sensor to receive the sensor signals in a first configuration of the electronic device, a second connector configured to detachably couple to the wearable attachment device in a second configuration of the electronic device, a controller configured to determine the physiological characteristic of the user based on the sensor signals, and a display configured to display the physiological characteristic of the user.

Abstract: Some embodiments of the methods and compositions provided herein relate to obtaining long read information from short reads of a target nucleic acid. Some embodiments include steps to selectively generate, mark, and amplify long nucleic acid fragments. Some embodiments include enriching for certain sequences in the long fragments with selection probes directed to certain genes throughout the genome and expressed regions with low mappability. Some embodiments also include fragmenting the long nucleic acid fragments into shorter fragments for sequencing, and informatically reconstructing a sequence of the target nucleic acid.

Abstract: Systems and methods for a bedside handle system having two-stage laser motion detection and wireless communication alert. The system detects and sends wireless alerts when a patient sits up and when the patient stands up. The system further includes a mobile app for receiving and displaying the alerts.

Abstract: Instrument and systems for applying ablative energy to epicardial tissue via a subxiphoid access surgical approach. The instrument has a head assembly sized and shaped for a subxiphoid surgical approach to a patient's heart and defines a contact face. The head assembly includes a paddle body, a first ablation electrode, and a second ablation electrode. The ablation electrodes are coupled to the paddle body in a spaced apart, spatially-fixed fashion. The ablation electrodes are exteriorly exposed at the contact face. A tubular member extends from the head assembly and maintains wiring connected to the ablation electrodes. The instrument is manipulable to locate the contact face on epicardial tissue of a patient's heart via a subxiphoid surgical approach, such as between the left and right pulmonary vein junctions of the posterior left atrium.

Abstract: A logic gate system for fault insertion testing can include a logic gate module having a plurality of input pins. The plurality of input pins can include an input signal pin configured to receive an input signal, a power supply input pin configured to receive power from a power supply, and a test input pin. The logic gate module can also include an output pin connected to the input pins via one or more logic gates. The logic gate system can include a power supply line connected to the power supply input pin and the test input pin. The logic gate system can also include a zero-ohm jumper resistor disposed between the power supply input pin and the test input pin. The zero-ohm resistor can be configured to be replaced with a low ohm resistor to allow reverse driving a voltage on the test input pin. The one or more logic gates can be configured to reverse an output at the output pin when the voltage on the test input pin is reverse driven.

Abstract: A logic gate system for fault insertion testing can include a logic gate module having a plurality of input pins. The plurality of input pins can include an input signal pin configured to receive an input signal, a power supply input pin configured to receive power from a power supply, and a test input pin. The logic gate module can also include an output pin connected to the input pins via one or more logic gates. The logic gate system can include a power supply line connected to the power supply input pin and the test input pin. The logic gate system can also include a zero-ohm jumper resistor disposed between the power supply input pin and the test input pin. The zero-ohm resistor can be configured to be replaced with a low ohm resistor to allow reverse driving a voltage on the test input pin. The one or more logic gates can be configured to reverse an output at the output pin when the voltage on the test input pin is reverse driven.

Abstract: A physiological characteristic monitoring system includes a wearable attachment device, an electronic device, and a physiological characteristic sensor (e.g., a glucose sensor) including a portion that is insertable into subcutaneous tissue of a user to generate sensor signals indicating a physiological characteristic of the user. The electronic device includes a first connector configured to detachably couple to the physiological characteristic sensor to receive the sensor signals in a first configuration of the electronic device, a second connector configured to detachably couple to the wearable attachment device in a second configuration of the electronic device, a controller configured to determine the physiological characteristic of the user based on the sensor signals, and a display configured to display the physiological characteristic of the user.

Abstract: A physiological characteristic monitoring system includes a physiological characteristic sensor that observes a physiological characteristic and generates sensor signals based on the observation. The physiological characteristic sensor includes a sensor connector. The physiological characteristic monitoring system includes a wearable device to be worn by a user in a first configuration and having a connector to couple to the sensor connector in a second configuration. The wearable device includes a controller that receives the sensor signals from the physiological characteristic sensor in the second configuration and determines a current value of the physiological characteristic based on the sensor signals.

Abstract: Systems and methods for a bedside handle system having two-stage laser motion detection and wireless communication alert. The system detects and sends wireless alerts when a patient sits up and when the patient stands up. The system further includes a mobile app for receiving and displaying the alerts.

Abstract: Systems and methods for a bedside handle system having two-stage laser motion detection and wireless communication alert. The system detects and sends wireless alerts when a patient sits up and when the patient stands up. The system further includes a mobile app for receiving and displaying the alerts.

Abstract: A system and method for obtaining user approval for transactions. The system includes an authorization system that is communicably coupled to one or more transaction computer systems that execute at least some transactions that require user approval. When a transaction system is seeking to execute a transaction that requires user approval, the transaction system sends a user approval request to the authorization system. The authorization system then retrieves the user's communication preference from a database and transmits an affirmatively actionable message to the user according to the retrieved communication preference. The messages can include an email with an approval link to click or a text message that the can be replied to. When the authorization system receives confirmation from the user that the user approves the request, the authorization system then transmits approval for the transaction to the appropriate transaction system, which then proceeds to execute the transaction.

Abstract: A method of measuring a physiological characteristic of a user obtains first calibrating sensor data indicative of an analyte level of the user, and produced in response to operation of a continuous analyte sensor device during a calibration period, and obtains second calibrating sensor data indicative of status or condition of the user, and produced in response to operation of a noninvasive sensor device, concurrently with operation of the continuous analyte sensor device, during the calibration period. A correlation measurement is calculated by comparing the first calibrating sensor data against the second calibrating sensor data. When the correlation measurement exceeds a threshold value, a transfer function is generated to calculate estimated values of the analyte level as a function of sensor data from the noninvasive sensor device. The transfer function is provided to a client device associated with the user.

Abstract: Instrument and systems for applying ablative energy to epicardial tissue via a subxiphoid access surgical approach. The instrument has a head assembly sized and shaped for a subxiphoid surgical approach to a patient's heart and defines a contact face. The head assembly includes a paddle body, a first ablation electrode, and a second ablation electrode. The ablation electrodes are coupled to the paddle body in a spaced apart, spatially-fixed fashion. The ablation electrodes are exteriorly exposed at the contact face. A tubular member extends from the head assembly and maintains wiring connected to the ablation electrodes. The instrument is manipulable to locate the contact face on epicardial tissue of a patient's heart via a subxiphoid surgical approach, such as between the left and right pulmonary vein junctions of the posterior left atrium.

Abstract: Instrument and systems for applying ablative energy to epicardial tissue via a subxiphoid access surgical approach. The instrument has a head assembly sized and shaped for a subxiphoid surgical approach to a patient's heart and defines a contact face. The head assembly includes a paddle body, a first ablation electrode, and a second ablation electrode. The ablation electrodes are coupled to the paddle body in a spaced apart, spatially-fixed fashion. The ablation electrodes are exteriorly exposed at the contact face. A tubular member extends from the head assembly and maintains wiring connected to the ablation electrodes. The instrument is manipulable to locate the contact face on epicardial tissue of a patient's heart via a subxiphoid surgical approach, such as between the left and right pulmonary vein junctions of the posterior left atrium.

Abstract: A system and method for obtaining user approval for transactions. The system includes an authorization system that is communicably coupled to one or more transaction computer systems that execute at least some transactions that require user approval. When a transaction system is seeking to execute a transaction that requires user approval, the transaction system sends a user approval request to the authorization system. The authorization system then retrieves the user's communication preference from a database and transmits an affirmatively actionable message to the user according to the retrieved communication preference. The messages can include an email with an approval link to click or a text message that the can be replied to. When the authorization system receives confirmation from the user that the user approves the request, the authorization system then transmits approval for the transaction to the appropriate transaction system, which then proceeds to execute the transaction.

Abstract: A physiological characteristic monitoring system includes a physiological characteristic sensor that observes a physiological characteristic and generates sensor signals based on the observation. The physiological characteristic sensor includes a sensor connector. The physiological characteristic monitoring system includes a wearable device to be worn by a user in a first configuration and having a connector to couple to the sensor connector in a second configuration. The wearable device includes a controller that receives the sensor signals from the physiological characteristic sensor in the second configuration and determines a current value of the physiological characteristic based on the sensor signals.

Abstract: Embodiments of the present disclosure include devices, systems, and methods for managing an emergency care event using a computing device. Simplified and touch-enabled user interface elements allow a wide variety of events to be selected and quickly entered into an event record. In some embodiments, care guidelines are programmed into the computing device, and are used by the computing device to guide the care team through the steps for various actions to ensure that adherence to the care guidelines is as close as possible. In some embodiments, timers for care events are automatically tracked by the computing device, and alerts are automatically generated in order to further increase compliance with time-based care guidelines.

Abstract: Methods for making and operating physiological characteristic sensors are presented here. An exemplary method includes providing a quantified effect of an electrical performance parameter on a calculation of a concentration of an analyte in a fluid sample. The method includes providing a group of sensors and testing a test sensor from the group of sensors with a known concentration of the analyte in a test sample to determine the electrical performance parameter of the test sensor. Further, the method includes associating the electrical performance parameter of the test sensor with a selected sensor from the group of sensors. The method may associate the quantified effect with the selected sensor, measure an unknown concentration of the analyte with the selected sensor, and input the measured electrical performance parameter and the quantified effect into an algorithm to provide an estimated blood analyte level.