Abstract: The invention relates to the use of red blood cells extracellular vesicle (RBCEV) to deliver nucleic acids to immune cells (e.g. T cells), wherein the nucleic acid cargoes are loaded into the RBCEV in vitro or ex vivo. The invention also relates to the prophylactic and therapeutic use of said immune cells in diseases, such as cancer.

Abstract: The present application relates to a silicon nanoprojection device comprising a substrate having a surface and one or more nanoprojection structures having a proximal end attached to said substrate and extending away from the surface of the substrate to a distal end. The one or more nanoprojection structures either have a configuration which tapers narrowingly from the proximal end to the distal end or have an ionic coating. Also disclosed are methods of making and using the silicon nanoprojection device.

Abstract: This invention relates to a method of imaging a downhole region of interest. In particular this invention relates to a method of processing images captured downhole to remove or reduce distortions due to the optical system as a function of the temperature experienced by the optical system in the downhole environment. A method of imaging a downhole region of interest comprises contemporaneously capturing an image of a region of interest and recording a temperature associated with the region of interest; selecting a pre-defined set of distortion data from a plurality of pre-defined sets of distortion data based on the recorded temperature; and applying the selected set of distortion data to the captured image to create an un-distorted image, wherein the pre-defined set of distortion data comprises distortion values associated with a range of field angles at a specified temperature.

Abstract: Inspection assemblies that include one or more sideview cameras for capturing images of an interior surface of a pipe or conduit include an elongate housing, a sideview camera within the housing and arranged to capture an image of a region within a field of view external to the housing, and a viewport element mounted in the housing and located such that light is transmitted through the viewport element and into said sideview camera, wherein the viewport element has a concave internal surface, closer to the camera, and a convex external surface, further from the camera, and wherein the centre of the radius of curvature of the internal surface is closer to the viewport element than the centre of the radius of curvature of the external surface.

Abstract: The field of inspection assemblies and in particular to inspection assemblies that include light sources for illuminating a field of view of a camera including an elongate housing having a longitudinal axis, a camera mounted in the housing and arranged to capture an image of a region within a field of view external to the housing, a light source mounted in the housing and arranged to illuminate the field of view, and a window element mounted in the housing, the window element comprising a light transmitting material and being located such that light emitted by the light source passes through the window element before illuminating the field of view. The window element has an internal surface, closer to the light source, and an external surface, further from the light source, and the external surface comprises a concave region.

Abstract: Inspection assemblies that include one or more sideview cameras for capturing images of an interior surface of a pipe or conduit include an elongate housing, a sideview camera within the housing and arranged to capture an image of a region within a field of view external to the housing, and a viewport element mounted in the housing and located such that light is transmitted through the viewport element and into said sideview camera, wherein the viewport element is diffusion bonded to a metal support.

Abstract: The field of inspection assemblies and in particular to inspection assemblies that include light sources for illuminating a field of view of a camera including an elongate housing having a longitudinal axis, a camera mounted in the housing and arranged to capture an image of a region within a field of view external to the housing, a light source mounted in the housing and arranged to illuminate the field of view, and a window element mounted in the housing, the window element comprising a light transmitting material and being located such that light emitted by the light source passes through the window element before illuminating the field of view. The window element has an internal surface, closer to the light source, and an external surface, further from the light source, and the external surface comprises a concave region.

Abstract: Inspection assemblies that include one or more sideview cameras for capturing images of an interior surface of a pipe or conduit include an elongate housing, a sideview camera within the housing and arranged to capture an image of a region within a field of view external to the housing, and a viewport element mounted in the housing and located such that light is transmitted through the viewport element and into said sideview camera, wherein the viewport element has a concave internal surface, closer to the camera, and a convex external surface, further from the camera, and wherein the centre of the radius of curvature of the internal surface is closer to the viewport element than the centre of the radius of curvature of the external surface.

Abstract: Inspection assemblies that include one or more sideview cameras for capturing images of an interior surface of a pipe or conduit include an elongate housing, a sideview camera within the housing and arranged to capture an image of a region within a field of view external to the housing, and a viewport element mounted in the housing and located such that light is transmitted through the viewport element and into said sideview camera, wherein the viewport element is diffusion bonded to a metal support.

Abstract: An inspection apparatus for use in wellbores in the oil and gas industries relates in general to the field of transmission of data between downhole module in a wellbore and a controlling module at the surface. The invention provides a method and apparatus for determining analog filter parameters for an analog front end comprising a plurality of filter stages receiving signals from a telemetry module, by repeating the steps of; receiving a signal of a known frequency and processing said signal by determining the magnitude of the frequency of the received signal until a plurality of signals have been received and processed; calculating an optimum set of filter parameters in dependence upon the measured frequency magnitudes and a predefined set of filter stage frequency responses.

Abstract: An inspection apparatus for use in wellbores in the oil and gas industries relates in general to the field of transmission of data between downhole module in a wellbore and a controlling module at the surface. The invention provides a method and apparatus for determining analogue filter parameters for an analogue front end comprising a plurality of filter stages receiving signals from a telemetry module, by repeating the steps of; receiving a signal of a known frequency and processing said signal by determining the magnitude of the frequency of the received signal until a plurality of signals have been received and processed; calculating an optimum set of filter parameters in dependence upon the measured frequency magnitudes and a predefined set of filter stage frequency responses.

Abstract: The present invention relates to inspection apparatus for use in wellbores in the oil and gas industries. In particular the invention relates in general to the field of transmission of data between downhole module in a wellbore and a controlling module at the surface. The invention provides a method and apparatus for determining analog filter parameters for an analog front end comprising a plurality of filter stages receiving signals from a telemetry module, by repeating the steps of; receiving a signal of a known frequency and processing said signal by determining the magnitude of the frequency of the received signal until a plurality of signals have been received and processed; calculating an optimum set of filter parameters in dependence upon the measured frequency magnitudes and a predefined set of filter stage frequency responses.

Abstract: The present invention relates to inspection apparatus for use in wellbores in the oil and gas industries. In particular the invention relates in general to the field of transmission of data between downhole module in a wellbore and a controlling module at the surface. The invention provides a method and apparatus for determining analogue filter parameters for an analogue front end comprising a plurality of filter stages receiving signals from a telemetry module, by repeating the steps of; receiving a signal of a known frequency and processing said signal by determining the magnitude of the frequency of the received signal until a plurality of signals have been received and processed; calculating an optimum set of filter parameters in dependence upon the measured frequency magnitudes and a predefined set of filter stage frequency responses.

Abstract: A thermophilic microorganism is modified to permit the increased production of ethanol, wherein a first modification is the inactivation of the lactate dehydrogenase gene and a second modification upregulates the pyruvate dehydrogenase gene.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: Modified microorganisms are prepared by inactivation of the endogenous lactate dehydrogenase gene. The microorganisms are deposited under NCIMB Accession Nos. 41277, 41278, 41279, 41280 or 41281.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.

Abstract: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.