Patents by Inventor Brian S. Bronk
Brian S. Bronk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6979692Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.Type: GrantFiled: August 13, 2003Date of Patent: December 27, 2005Assignee: Pfizer Inc.Inventors: Peter Bertinato, Alan E. Blize, Brian S. Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
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Patent number: 6949572Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.Type: GrantFiled: August 13, 2003Date of Patent: September 27, 2005Assignee: Pfizer Inc.Inventors: Peter Bertinato, Brian S. Bronk, Alan E. Blize, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
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Patent number: 6846818Abstract: The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the invention are particularly useful in the treatment or alleviation of inflammation and inflammation associated disorders, such as, for example, rheumatoid arthritis and osteoarthritis, and in the relief of pain, such as, for example, pain associated with surgery or trauma, in mammals, preferably felines and canines.Type: GrantFiled: April 16, 2003Date of Patent: January 25, 2005Assignee: Pfizer Inc.Inventors: Kristin Lundy DeMello, Brian S. Bronk, Rhonda Marie Crosson
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Patent number: 6841671Abstract: The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said “A” is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.Type: GrantFiled: October 23, 2001Date of Patent: January 11, 2005Assignee: Pfizer Inc.Inventors: Mark C. Noe, Martin J. Wythes, Brian S. Bronk
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Publication number: 20040132745Abstract: The present invention provides inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion having Formula (I) which are useful for the treatment of obesity and related diseases, as well as prevention and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and in the prevention and treatment of related diseases. The invention further relates to pharmaceutical compositions comprising the compounds of the present invention and to methods of treating obesity, atherosclerosis, and related diseases and/or conditions with the compounds of the present invention, either alone or in combination with other medicaments, including lipid-lowering agents.Type: ApplicationFiled: December 19, 2003Publication date: July 8, 2004Applicant: Pfizer IncInventors: Peter Bertinato, Brian S. Bronk, Henry Cheng, George Chang, Bridget M. Cole, Jin Li, Roger B. Ruggeri
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Publication number: 20040087625Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 1Type: ApplicationFiled: August 13, 2003Publication date: May 6, 2004Applicant: Pfizer IncInventors: Peter Bertinato, Brian S. Bronk, Alan E. Blize, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
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Patent number: 6720351Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.Type: GrantFiled: June 20, 2002Date of Patent: April 13, 2004Assignee: Pfizer Inc.Inventors: Peter Bertinato, Alan E. Blize, Brian S. Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
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Patent number: 6649636Abstract: This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is (C1-C4)alkyl optionally substituted with halo, amino or an alkyl amino; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.Type: GrantFiled: November 28, 2000Date of Patent: November 18, 2003Assignee: Pfizer Inc.Inventors: Kazuo Ando, Martha L. Minich, Jin Li, Subas M. Sakya, Kristin M. Lundy, Hengmiao Cheng, Brian S. Bronk, Kiyoshi Kawamura, Tomoki Kato
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Publication number: 20030207897Abstract: The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: 1Type: ApplicationFiled: April 16, 2003Publication date: November 6, 2003Applicant: Pfizer Inc.Inventors: Kristin Lundy DeMello, Brian S. Bronk, Rhonda Marie Crosson
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Publication number: 20030187053Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 1Type: ApplicationFiled: June 20, 2002Publication date: October 2, 2003Applicant: Pfizer Inc.Inventors: Peter Bertinato, Alan E. Blize, Brian S. Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
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Publication number: 20030186957Abstract: Formulations containing an antibacterial alkali metal salt of a cephalosporin compound and methods of treating bacterial infections in dogs and cats.Type: ApplicationFiled: November 12, 2002Publication date: October 2, 2003Inventors: Simon E. Blanchflower, Roger N. Kimball, Renuka D. Reddy, Evgenyi Y. Shalaev, Brian S. Bronk
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Publication number: 20030149013Abstract: The invention described herein relates to the treatment of a range of bacterial infections in companion animals, in particular cats and dogs, with a &bgr;-lactam derivative, compound of Formula I. The invention is also directed to pharmaceutical compositions of a compound of Formula I.Type: ApplicationFiled: November 12, 2002Publication date: August 7, 2003Inventors: Simon E. Blanchflower, Brian S. Bronk
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Publication number: 20030096803Abstract: The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula 1Type: ApplicationFiled: October 23, 2001Publication date: May 22, 2003Inventors: Mark C. Noe, Martin J. Wythes, Brian S. Bronk
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Patent number: 6194578Abstract: This invention is directed to compounds of the Formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are therapeutically effective in treating osteoporosis and/or frailty, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintenance of skin thickness, metabolic homeostasis or renal homeostasis.Type: GrantFiled: July 7, 1999Date of Patent: February 27, 2001Assignee: Pfizer Inc.Inventors: David A. Griffith, Brian S. Bronk
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Patent number: 6100240Abstract: The invention relates to compounds of the formula I ##STR1## and to pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, Q, X, Y and Z are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I, methods of using said compounds of formula I in the treatment of infections, and methods of preparing said compounds of formula I.Type: GrantFiled: September 16, 1999Date of Patent: August 8, 2000Assignee: Pfizer IncInventors: Hengmiao Cheng, Robert John Rafka, Jason K. Dutra, Michael A. Letavic, Brian S. Bronk
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Patent number: 6043227Abstract: This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial agents that may be used to treat various bacterial infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.Type: GrantFiled: May 26, 1999Date of Patent: March 28, 2000Assignee: Pfizer Inc.Inventors: Hengmiao Cheng, Michael Letavic, Carl B. Ziegler, Jr., Jason K. Dutra, Peter Bertinato, Brian S. Bronk