Patents by Inventor Brian S. Hill
Brian S. Hill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130292266Abstract: A system for testing for analytes in a sample of biological fluid includes a test strip that defines a cavity for receiving the sample. At least two sets of electrodes are adjacent the sample cavity, including one for measuring one property of the sample, and another for measuring one or more other properties of the sample, such as temperature and/or the presence or magnitude of confounding variables. The measurements are combined to yield the desired result. At least one set of working and counter electrodes each have a plurality of elongated “fingers” interdigitated with those of the other electrode in the set. The gaps between fingers can be quite small, so that the two electrode sets together can operate in a small measurement volume of sample. Additional electrodes can be included that measure the presence or sufficiency of the sample, and additional traces on the strip can act as configuration identifiers.Type: ApplicationFiled: July 8, 2013Publication date: November 7, 2013Inventors: Nigel A. Surridge, P. Douglas Walling, Melani Sullivan, Vladimir Svetnik, Brian S. Hill
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Patent number: 8551308Abstract: An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.Type: GrantFiled: September 25, 2008Date of Patent: October 8, 2013Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel Surridge, Paul Douglas Walling
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Patent number: 8506775Abstract: A system for testing for analytes in a sample of biological fluid includes a test strip that defines a cavity for receiving the sample. At least two sets of electrodes are adjacent the sample cavity, including one for measuring one property of the sample, and another for measuring one or more other properties of the sample, such as temperature and/or the presence or magnitude of confounding variables. The measurements are combined to yield the desired result. At least one set of working and counter electrodes each have a plurality of elongated “fingers” interdigitated with those of the other electrode in the set. The gaps between fingers can be quite small, so that the two electrode sets together can operate in a small measurement volume of sample. Additional electrodes can be included that measure the presence or sufficiency of the sample, and additional traces on the strip can act as configuration identifiers.Type: GrantFiled: June 18, 2004Date of Patent: August 13, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Nigel Anthony Surridge, Paul Douglas Walling, Melani Sullivan, Vladimir Svetnik, Brian S. Hill
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Patent number: 8287703Abstract: An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.Type: GrantFiled: September 25, 2008Date of Patent: October 16, 2012Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel Surridge, Paul Douglas Walling
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Patent number: 7867369Abstract: A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.Type: GrantFiled: June 18, 2004Date of Patent: January 11, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir S. Bhullar, Harvey B. Buck, Jr., Brian S. Hill, Paul Douglas Walling, Terry A. Beaty, David W. Burke, Eric R. Diebold
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Publication number: 20090056120Abstract: An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.Type: ApplicationFiled: September 25, 2008Publication date: March 5, 2009Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel Surridge, Paul Douglas Walling
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Publication number: 20090020502Abstract: An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.Type: ApplicationFiled: September 25, 2008Publication date: January 22, 2009Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel Surridge, Paul Douglas Walling
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Patent number: 7479211Abstract: A method of forming a biosensor is provided in accordance with the present invention. The method includes providing a metallized electrode support substrate and a sensor support, ablating the electrode support substrate to form electrodes, coupling the sensor support substrate to the electrode support substrate, and positioning spaced-apart electrically conductive tracks across the sensor support substrate so that each track is in electrical communication with one electrode.Type: GrantFiled: May 13, 2004Date of Patent: January 20, 2009Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir S. Bhullar, John T. Austera, Brian S. Hill, Christopher D. Wilsey
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Patent number: 7386937Abstract: A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 ?m along the length of the edge.Type: GrantFiled: May 1, 2006Date of Patent: June 17, 2008Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel A. Surridge, Douglas P. Walling
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Patent number: 7287318Abstract: A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.Type: GrantFiled: November 7, 2003Date of Patent: October 30, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir S. Bhullar, Christopher D. Wilsey, Brian S. Hill
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Patent number: 7073246Abstract: A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 ?m.Type: GrantFiled: June 20, 2003Date of Patent: July 11, 2006Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel A. Surridge, Douglas P. Walling
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Patent number: 7063774Abstract: A biosensor is provided that comprises a substrate, a sample site positioned on the substrate, a cover coupled to the substrate, and biocide positioned between the substrate and the cover. The biosensor may also include desiccant. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.Type: GrantFiled: October 28, 2002Date of Patent: June 20, 2006Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir Singh Bhullar, Douglas Paul Walling, Brian S. Hill
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Patent number: 6911621Abstract: A method of forming a biosensor is provided. The method includes providing a substrate and a cover including first and second surfaces, positioning a reagent on the substrate, carving a channel by laser ablation in the first surface, and coupling the first surface of the cover to the second surface. The channel includes a first portion having a first height and a second portion having a second height that is less than the first height.Type: GrantFiled: January 8, 2003Date of Patent: June 28, 2005Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, Douglas P. Walling, Brian S. Hill
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Patent number: 6866758Abstract: A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support, each electrode including a meter-contact portion and a measurement portion, and a sensor support substrate. The sensor support substrate cooperates with the electrode support substrate to define channel in alignment with the measurement portion of the electrodes. Additionally, the sensor support substrate includes opposite ends and at least one window. The at least one window is spaced-apart from the ends and in alignment with the meter-contact portion of at least one of the electrodes.Type: GrantFiled: March 21, 2002Date of Patent: March 15, 2005Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, Brian S. Hill, John T. Austera
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Patent number: 6814843Abstract: A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a top side and a generally flat bottom side. The bottom side is coupled to the substrate to define a sealed portion and an unsealed portion. The unsealed portion cooperates with the substrate to define a channel extending across the reagent.Type: GrantFiled: November 1, 2000Date of Patent: November 9, 2004Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, Douglas P. Walling, Brian S. Hill
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Publication number: 20040206625Abstract: A method of forming a biosensor is provided in accordance with the present invention. The method includes providing a metallized electrode support substrate and a sensor support, ablating the electrode support substrate to form electrodes, coupling the sensor support substrate to the electrode support substrate, and positioning spaced-apart electrically conductive tracks across the sensor support substrate so that each track is in electrical communication with one electrode.Type: ApplicationFiled: May 13, 2004Publication date: October 21, 2004Inventors: Raghbir S. Bhullar, John T. Austera, Brian S. Hill, Christopher D. Wilsey
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Publication number: 20040194302Abstract: A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points.Type: ApplicationFiled: June 20, 2003Publication date: October 7, 2004Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel A. Surridge, P. Douglas Walling
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Publication number: 20040163953Abstract: A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.Type: ApplicationFiled: November 7, 2003Publication date: August 26, 2004Inventors: Raghbir S. Bhullar, Christopher D. Wilsey, Brian S. Hill
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Publication number: 20040144644Abstract: A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support substrate, a sensor support substrate coupled to the electrode support substrate, and electrically conductive tracks positioned on the sensor support substrate. Each track is in electrical communication with one of the electrodes.Type: ApplicationFiled: April 24, 2001Publication date: July 29, 2004Inventors: Raghbir S. Bhullar, John T. Austera, Brian S. Hill, Christopher D. Wilsey
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Patent number: 6767440Abstract: A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support substrate, a sensor support substrate coupled to the electrode support substrate, and electrically conductive tracks positioned on the sensor support substrate. Each track is in electrical communication with one of the electrodes.Type: GrantFiled: April 24, 2001Date of Patent: July 27, 2004Assignee: Roche Diagnostics CorporationInventors: Raghbir S. Bhullar, John T. Austera, Brian S. Hill, Christopher D. Wilsey