Patents by Inventor Brian S. J. Blagg

Brian S. J. Blagg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DYNAMIC INHIBITORS OF HEAT SHOCK PROTEIN 90
    Publication number: 20120309702
    Abstract: An inhibitor of heat shock protein 90 (HSP90) can include a coumermycin A1 analog having a structure that inhibits HSP90 greater than coumermycin A1. That is, the coumermycin A1 analog is not coumermycin A1. The coumermycin A1 analog can have an antiproliferative biological activity, which can be superior to coumermycin A1. The activity can include the coumermycin A1 analog inhibiting a C-terminus of HSP90.
    Type: Application
    Filed: May 16, 2012
    Publication date: December 6, 2012
    Applicant: UNIVERSITY OF KANSAS
    Inventors: Brian S.J. Blagg, Bhaskar Reddy Kusuma
  • NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES
    Publication number: 20120252745
    Abstract: The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.
    Type: Application
    Filed: February 19, 2010
    Publication date: October 4, 2012
    Inventors: Brian S. J. Blagg, Huiping Zhao, Alison Catherine Donnelly
  • Novobiocin analogues having modified sugar moieties
    Patent number: 8212012
    Abstract: Novobiocin analogues useful as Hsp90 inhibitors in the treatment of cancer, neuroprotection, and autoimmune disorders.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: July 3, 2012
    Assignee: University of Kansas
    Inventor: Brian S. J. Blagg
  • Heat shock protein 90 inhibitors
    Patent number: 8188306
    Abstract: Novel compounds useful for inhibiting the 90kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: May 29, 2012
    Assignee: University of Kansas
    Inventors: Brian S. J. Blagg, Gang Shen
  • Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
    Patent number: 7960353
    Abstract: Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: June 14, 2011
    Assignee: University of Kansas
    Inventor: Brian S. J. Blagg
  • NOVOBIOCIN ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE
    Publication number: 20110082098
    Abstract: Novobiocin analogues are useful in methods of treating, inhibiting, and/or preventing cyst formation in autosomal dominant polycystic kidney disease (ADPKD) in a subject. The disclosure provides methods of treating ADPKD comprising administering a therapeutically effective amount of a coumarin-3-carboxamide novobiocin analogue. Accordingly, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of mTOR pathway phosphoproteins P-mTOR, P-Akt and P-S6K, or combinations thereof. Further, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of Hsp-90 client proteins CFTR, ErbB2, c-Raf and Cdk4, or combinations thereof.
    Type: Application
    Filed: September 30, 2010
    Publication date: April 7, 2011
    Applicant: UNIVERSITY OF KANSAS
    Inventors: James P. Calvet, Brian S.J. Blagg, Shirin V. Sundar, Brenda S. Magenheimer
  • NOVOBIOCIN ANALOGUES AS NEUROPROTECTIVE AGENTS AND IN THE TREATMENT OF AUTOIMMUNE DISORDERS
    Publication number: 20100105630
    Abstract: Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
    Type: Application
    Filed: October 12, 2009
    Publication date: April 29, 2010
    Applicant: UNIVERSITY OF KANSAS
    Inventor: Brian S.J. Blagg
  • HEAT SHOCK PROTEIN 90 INHIBITORS
    Publication number: 20100099865
    Abstract: Novel compounds useful for inhibiting the 90kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
    Type: Application
    Filed: September 30, 2009
    Publication date: April 22, 2010
    Applicant: UNIVERSITY OF KANSAS
    Inventors: Brian S.J. Blagg, Gang Shen