Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.

Abstract: A program code executing on a processing system includes one or more instructions each identifying a workload that includes a plurality of waves and each identifying resource allocations for the plurality of waves of the workgroup. In response to receiving an instruction identifying a workload and resource allocations for the plurality of waves of the workgroup, a processor allocates a first set of processing resources to a compute unit of the processor based on the resource allocations for the plurality of waves. The compute unit then performs operations for the workgroup using the allocated set of processing resources.

Abstract: A sealant delivery device includes a housing, a matrix container connected with a distal end of the housing and being moveable between closed and opened positions, and a matrix, such as a hemostatic substrate, disposed within the matrix container. The sealant delivery device includes a sealant dispensing system in fluid communication with the matrix container that is configured for dispensing a sealant onto the matrix disposed within the matrix container. An actuator is coupled with the sealant dispensing system and the matrix container. The actuator is engageable for opening the matrix container for exposing the matrix and expressing the sealant onto the matrix. A component of the matrix container may be used to press the matrix and sealant expressed onto the matrix against target tissue to control bleeding of the target tissue.

Abstract: Systems and methods are disclosed herein for opening files via local application.

Abstract: A lithotripsy device can comprise a handpiece, a lithotripsy probe extending from the handpiece, an energization source configured to deliver an energy to a distal end of the lithotripsy probe, a suction passage extending from the distal end of the probe and through the handpiece, and a capture device comprising a container comprising a storage space, an entry port configured to couple to the handpiece at the suction passage, and an exit port, and a capture element connected to the container and configured to facilitate capture of stone fragments within the storage space. A method can comprise fragmenting stones with a lithotripsy device, drawing a vacuum through the lithotripsy device to pull stone fragments and waste fluid therethrough, pulling the vacuum through a stone capture device connected to the lithotripsy device, depositing stone fragments within the stone capture device using a capture element, and drawing the vacuum through the device.

Abstract: Systems and methods for content storage and retrieval are disclosed herein for accessing portions of a file at a client device. A client device receives a request to access a file at the client device. The file includes file portions that are stored at a web-based storage system in communication with the client device via a network. The client device provides the web-based storage system with access to a metafile stored on the client device. The metafile includes an identifier for each of the file portions for the file and an indication of whether each of the file portions are already stored on the client device. In response to the web-based storage system accessing the metafile stored on the client device to identify a set of file portions that is not stored on the client device, the client device receives the identified set of file portions from the web-based storage system via the network.

Abstract: A lithotripsy device can comprise a handpiece, a lithotripsy probe extending from the handpiece, an energization source configured to deliver an energy to a distal end of the lithotripsy probe, a suction passage extending from the distal end of the probe and through the handpiece, and a capture device comprising a container comprising a storage space, an entry port configured to couple to the handpiece at the suction passage, and an exit port, and a capture element connected to the container and configured to facilitate capture of stone fragments within the storage space. A method can comprise fragmenting stones with a lithotripsy device, drawing a vacuum through the lithotripsy device to pull stone fragments and waste fluid therethrough, pulling the vacuum through a stone capture device connected to the lithotripsy device, depositing stone fragments within the stone capture device using a capture element, and drawing the vacuum through the device.

Abstract: A lithotripsy device can comprise a handpiece, a lithotripsy probe extending from the handpiece, an energization source configured to deliver an energy to a distal end of the lithotripsy probe, a suction passage extending from the distal end of the probe and through the handpiece, and a capture device comprising a container comprising a storage space, an entry port configured to couple to the handpiece at the suction passage, and an exit port, and a capture element connected to the container and configured to facilitate capture of stone fragments within the storage space. A method can comprise fragmenting stones with a lithotripsy device, drawing a vacuum through the lithotripsy device to pull stone fragments and waste fluid therethrough, pulling the vacuum through a stone capture device connected to the lithotripsy device, depositing stone fragments within the stone capture device using a capture element, and drawing the vacuum through the device.

Abstract: Systems and methods are disclosed herein for opening files via local application.

Abstract: An underground sensing arrangement for use in a fueling environment comprises at least one sensor located under a ground surface and a power supply. The sensor is operative to detect a condition in the fueling environment. A wireless transceiver is in electrical communication with the at least one sensor and the power supply. The wireless transceiver has an environmental housing and electrical circuitry contained within the environmental housing. The electrical circuitry includes control circuitry, radio circuitry, and an antenna. The environmental housing is substantially transparent to electromagnetic frequencies at which the wireless transceiver operates and is potted substantially flush with the ground surface.

Abstract: Systems and methods are disclosed herein for opening files via local applications. A first application on a local device receives a request to open a document specified by a user via a user interface associated with the first application, the document having a document identifier and associated with a first file stored on a server. The first application communicates the request to open the document associated with the first file to a second application on the local device, and receives, from the second application, information identifying one of the plurality of document processing applications that are on the local device and are capable of opening a second file that is stored on the local device and has the same document identifier as the document specified by the user, the second file being a local copy of the first file.

Abstract: Systems and methods for content storage and retrieval are disclosed herein for accessing portions of a file at a client device. A client device receives a request to access a file at the client device. The file includes file portions that are stored at a web-based storage system in communication with the client device via a network. The client device provides the web-based storage system with access to a metafile stored on the client device. The metafile includes an identifier for each of the file portions for the file and an indication of whether each of the file portions are already stored on the client device. In response to the web-based storage system accessing the metafile stored on the client device to identify a set of file portions that is not stored on the client device, the client device receives the identified set of file portions from the web-based storage system via the network.

Abstract: Systems and methods are disclosed herein for accessing portions of a file at a client device. One or more portions of a file are selected for downloading to the client device, wherein the file is stored on a web-based storage system in communication with the client device via a network. At least one portion in the selected one or more portions is identified that is not stored on the client device. A request is transmitted, without user interaction, to the web-based storage system to download the identified at least one portion of the file, and the identified at least one portion of the file is downloaded to the client device via the network.

Abstract: A system and method for detecting Trojans and other intermittent severe defects in a digital circuit design. A simulation of the digital circuit design results in a value change dump file, which is compiled to form a value change summary file containing counts of the numbers of value changes for the signals in the digital circuit design. A discriminative neural network analyzes the value change summary file to determine whether an intermittent severe defect is present. A corpus of digital circuit designs, with and without intermittent severe defects, is used to train the discriminative neural network. The training process may involve dimensionality reduction of the data, enlargement of the data set, and data compression using an autoencoder.

Abstract: Systems and methods are disclosed herein for opening files via local applications. A first application on a local device receives a request to open a document specified by a user via a user interface associated with the first application, the document having a document identifier and associated with a first file stored on a server. The first application communicates the request to open the document associated with the first file to a second application on the local device, and receives, from the second application, information identifying one of the plurality of document processing applications that are on the local device and are capable of opening a second file that is stored on the local device and has the same document identifier as the document specified by the user, the second file being a local copy of the first file.

Abstract: Systems and methods are disclosed herein for opening files via local applications. A first application on a local device receives a request to open a document specified by a user via a user interface associated with the first application, the document having a document identifier and associated with a first file stored on a server, the request comprising the document identifier and a user identifier. The first application forwards the request to open the document associated with the first file to a second application on the local device, and receives, from the second application, a list comprising one or more document processing applications that are on the local device and are capable of opening a second file that is stored on the local device and has the same document identifier as the document specified by the user, the second file being a local copy of the first file.

Abstract: A support coupling which provides a frangible point for a lighting fixture, and which prevents water from accumulating at the frangible point and from penetrating an inner chamber of the lighting fixture where electronic components are disposed includes an inner wall and an outer wall. The inner wall has a higher grade (i.e., is taller) than the outer wall. A space between the inner wall and the outer wall receives an extension column. Water running down the sides of the extension column is collected in the space and pours out of the coupling over the shorter outer wall before the water reaches the top of the inner wall.

Abstract: A system and method for detecting Trojans and other intermittent severe defects in a digital circuit design. A simulation of the digital circuit design results in a value change dump file, which is compiled to form a value change summary file containing counts of the numbers of value changes for the signals in the digital circuit design. A discriminative neural network analyzes the value change summary file to determine whether an intermittent severe defect is present. A corpus of digital circuit designs, with and without intermittent severe defects, is used to train the discriminative neural network. The training process may involve dimensionality reduction of the data, enlargement of the data set, and data compression using an autoencoder.