Patents by Inventor Brian Sherer

Brian Sherer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230019491
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKK? inhibitors.
    Type: Application
    Filed: October 17, 2018
    Publication date: January 19, 2023
    Inventors: Srinivasa R. Karra, Yufang XIAO, Brian Sherer
  • Patent number: 11440899
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKK? inhibitors.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: September 13, 2022
    Assignee: Merck Patent GmbH
    Inventors: Srinivasa R. Karra, Yufang Xiao, Brian Sherer, Eugene Checkler
  • Publication number: 20210300940
    Abstract: Compounds of Formula (I) and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists.
    Type: Application
    Filed: July 29, 2019
    Publication date: September 30, 2021
    Applicant: Merck Patent GmbH
    Inventors: Brian Sherer, Ruoxi Lan, Nadia Brugger, Xiaoling Chen, Momar Toure, Esther Cleary, Lizbeth Celeste Deselm, Yanping Wang
  • Publication number: 20210214339
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKK? inhibitors.
    Type: Application
    Filed: October 17, 2018
    Publication date: July 15, 2021
    Inventors: Srinivasa R. KARRA, Yufang XIAO, Brian SHERER, Eugene CHECKLER
  • Patent number: 8399489
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: March 19, 2013
    Assignee: Astrazeneca AB
    Inventors: Gregory Basarab, Brian Dangel, Paul Robert Fleming, Michael Barry Gravestock, Oluyinka Green, Sheila Irene Hauck, Pamela Hill, Kenneth Gregory Hull, George Mullen, Haihong Ni, Brian Sherer, Fei Zhou
  • Patent number: 8283361
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: October 9, 2012
    Assignee: AstraZeneca AB
    Inventors: Allison Laura Choy, Pamela Hill, John Irvin Manchester, Brian Sherer
  • Publication number: 20120101100
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: February 25, 2009
    Publication date: April 26, 2012
    Inventors: Shanta Bist, Brian Dangel, Brian Sherer
  • Publication number: 20120028979
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: October 6, 2011
    Publication date: February 2, 2012
    Inventors: Gregory BASARAB, Pamela HILL, Brian SHERER, Fei ZHOU
  • Patent number: 8071605
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: December 6, 2011
    Assignee: AstraZeneca AB
    Inventors: Gregory Basarab, Pamela Hill, Brian Sherer, Fei Zhou
  • Publication number: 20100317624
    Abstract: Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: June 7, 2010
    Publication date: December 16, 2010
    Inventors: Allison Laura CHOY, Ann EAKIN, Olga QUIROGA, Brian SHERER
  • Publication number: 20100190745
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: June 3, 2009
    Publication date: July 29, 2010
    Applicant: AstraZeneca AB
    Inventors: Allison Laura Choy, Pamela Hill, John Irvin Manchester, Brian Sherer
  • Publication number: 20100179150
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: February 16, 2006
    Publication date: July 15, 2010
    Applicant: ASTRAZENECA AB
    Inventors: Gregory Basarab, Brian Dangel, Paul Robert Fleming, Michael Barry Gravestock, Oluyinka Green, Sheila Irene Hauck, Pamela Hill, Kenneth Gregory Hull, George Mullen, Brian Sherer, Fei Zhou, Haihong Ni
  • Publication number: 20100173909
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: December 10, 2009
    Publication date: July 8, 2010
    Applicant: ASTRAZENECA AB
    Inventors: Gregory BASARAB, Pamela HILL, Brian SHERER, Fei ZHOU
  • Patent number: 7674801
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: March 9, 2010
    Assignee: AstraZeneca AB
    Inventors: Gregory Steven Basarab, Shanta Bist, John Irvin Manchester, Brian Sherer
  • Publication number: 20090325902
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: June 3, 2009
    Publication date: December 31, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Brian Sherer, Fei Zhou
  • Publication number: 20080312211
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described: formula (I). Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: December 19, 2006
    Publication date: December 18, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Gregory Basarab, Haihong Ni, Brian Sherer, Fei Zhou
  • Publication number: 20080161306
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described: Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: February 16, 2006
    Publication date: July 3, 2008
    Inventors: Brian Sherer, Fei Zhou
  • Publication number: 20080132546
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: December 4, 2007
    Publication date: June 5, 2008
    Applicant: AstraZeneca AB
    Inventors: Gregory Steven Basarab, Shanta Bist, John Irvin Manchester, Brian Sherer
  • Publication number: 20070299117
    Abstract: Disclosed are compounds of formula I: and the pharmaceutically acceptable salts thereof wherein the variables RN, R1, R2, R3, Rp and RC are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: July 17, 2007
    Publication date: December 27, 2007
    Inventors: Jed Fisher, Jon Jacobs, Brian Sherer
  • Patent number: 7244755
    Abstract: Disclosed are compounds of formula I: and the pharmaceutically acceptable salts thereof wherein the variables RN, R1, R2, R3, RP and RC are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: July 17, 2007
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jed F. Fisher, Jon S. Jacobs, Brian Sherer