Patents by Inventor Brian Shoichet

Brian Shoichet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective Agonists of 5-HT2A Receptor and Methods of Use
    Publication number: 20230365542
    Abstract: In one aspect, the present disclosure describes tetrahydropyridine compounds of formula (I), which are 5-HT2A receptor agonists that exhibit selective binding to the 5-HT2A receptor over the 5-HT2B receptor. In certain embodiments, the compound of formula (I) is a compound of formula (II). Also provided herein are methods of treating, ameliorating, and/or preventing neurological diseases and disorders with compounds of formula (II).
    Type: Application
    Filed: September 27, 2021
    Publication date: November 16, 2023
    Applicant: The Regents of the University of California
    Inventors: Jonathan Ellman, Danielle Confair, Oh Sang Kweon, Bryan Roth, Kuglae Kim, Brian Shoichet, Anat Levit, John Irwin
  • FLUOROPHENYL SUBSTITUTED MUSCARINIC RECEPTOR LIGANDS WITH SELECTIVITY FOR M3 OVER M2
    Publication number: 20200308168
    Abstract: The present invention relates to fluorophenyl substituted muscarinic receptor ligands with selectivity for M3 over M2 and to the use of these compounds in the treatment of various diseases such as asthma, chronic obstructive pulmonary disease (COPD), bronchopulmonary dysplasia (BPD) and urinary incontinence.
    Type: Application
    Filed: December 3, 2018
    Publication date: October 1, 2020
    Applicants: Friedrich-Alexander-Universität Erlangen-Nürnberg, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
    Inventors: Ashutosh BANERJEE, Amelie BARTUSCHAT, Katrin EITEL, Peter GMEINER, Markus HEINRICH, Josefa HOFMANN, Harald HÜBNER, Hannelore RAMPP, Benjamin SCHAAKE, Brian KOBILKA, Roger SUNAHARA, Mary Joyce CLARK, Inbar FISH, Brian SHOICHET
  • Compositions and methods for altering immune function
    Patent number: 7601355
    Abstract: The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: October 13, 2009
    Assignee: Northwestern University
    Inventors: Laurence Howard, Stephen Miller, Brian Shoichet, John Irwin
  • Compositions and methods for altering immune function
    Publication number: 20070041981
    Abstract: The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.
    Type: Application
    Filed: June 1, 2006
    Publication date: February 22, 2007
    Inventors: Laurence Howard, Stephen Miller, Brian Shoichet, John Irwin
  • Sterically-awkward beta-lactamase inhibitors
    Publication number: 20050245498
    Abstract: Sterically-awkward 6-?-substituted P-lactam compounds as inhibitors of ?-lactamase activity, such compounds as can be used in conjunction with one or more ?-lactam antibiotics in a system for treatment of a ?-lactam resistant bacterial infection.
    Type: Application
    Filed: March 17, 2005
    Publication date: November 3, 2005
    Inventors: Brian Shoichet, Larry Blaszczak
  • Inhibitors of &bgr;-lactamases and uses therefor
    Patent number: 6417174
    Abstract: The invention provides novel non-&bgr;-lactam inhibitors of &bgr;-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (1) which is set forth in the specification. These compounds may be used with &bgr;-lactam antibiotics to treat 62 -lactam-antibiotic-resistant bacterial infections. These compounds are also antibacterial by themselves. Finally, the invention provides a pharmaceutical composition comprising these compounds.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: July 9, 2002
    Assignee: Northwestern University
    Inventors: Brian Shoichet, Scott Weston
  • Inhibitors of .beta.-lactamases and uses therefor
    Patent number: 6075014
    Abstract: The invention provides novel non-.beta.-lactam inhibitors of .beta.-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (1) which is set forth in the specification. These compounds may be used with .beta.-lactam antibiotics to treat .beta.-lactam-antibiotic-resistant bacterial infections. These compounds are also antibacterial by themselves. Finally, the invention provides a pharmaceutical composition comprising these compounds.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: June 13, 2000
    Assignee: Northwestern University
    Inventors: Scott Weston, Brian Shoichet