Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.

Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.

Abstract: A thread rolling die includes a thread rolling region comprising a working surface including a thread form. The thread rolling region of the thread rolling die comprises a sintered cemented carbide material having a hardness in the range of 78 HRA to 89 HRA. In certain embodiments, the thread rolling die may further include at least one non-cemented carbide piece metallurgically bonded to the thread rolling region in an area of the thread rolling region that does not prevent a workpiece from contacting the working surface, and wherein the non-cemented carbide piece comprises at least one of a metallic region and a metal matrix composite region. Methods of forming a thread rolling die as embodied herein are also disclosed.

Abstract: The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

Abstract: The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

Abstract: In various embodiments, a tapered thread roll, a set of tapered thread rolls, a thread rolling tool, and a thread rolling method are provided for rolling angled or tapered threads onto a workpiece to create a threaded workpiece. In at least one embodiment, the threaded workpiece may comprise a polished rod or a polished rod precursor as specified by the American Petroleum Institute for use in an oil-field sucker-type pump, for example.

Abstract: An autonomous underwater plow can include a frame, a plow assembly and a propulsion assembly. The plow assembly is fixed to the one end of the frame, while the propulsion assembly is pivotably attached to the other end. The propulsion assembly includes thrusters that are rigidly coupled to a float, and that provide a propulsion force perpendicular to the float buoyancy force. The plow sinks when placed in the water, but the float provides sufficient buoyancy so that the float end floats while the plow end is in contact with the ocean floor. This establishes a rake angle of between the frame and ocean floor. The plow requires less propulsion force for motion because part of the plow is floating, and requires less force to overcome obstacles on the ocean floor because the thrusters provides a constant horizontal propulsion force while the frame tilts to overcome the obstacle.

Abstract: An underwater plow includes a plow assembly that is attached to a frame. The plow assembly includes a blade portion, which defines a blade trough, and a sensor chute portion. The blade portion extends downwardly below a plane that is coincident with a longitudinal axis defined by the frame, while the chute portion extends upwardly above the same plane. A depressor arm is pivotably attached to the blade portion and biased to be in contact with the trough. The depressor arm has a groove that is sized to allow the cable, but not the sensors, to pass through the groove while the depressor arm is in contact with the trough. With this configuration, an array cable passes downward through the blade portion of the plow assembly and becomes buried in the ocean floor. Array sensors, however, are routed upward and pass through the chute portion of the plow assembly.

Abstract: An underwater plow can include a depressor cam and a chute cam that are pivotably attached to a blade portion. The blade portion can be formed with a trough and the depressor cam can be biased in the trough. The chute cam can be formed with a groove having a minimum thickness at its attached end and an increasing taper to a maximum thickness at its distal end. A sensor passing through the plow contacts the edge of the depressor cam, causing depressor cam rotation away from the trough. The sensor passes the depressor cam and pushes against the chute cam, which causes the chute cam to contra-rotate relative to the depressor cam until the sensor passes through the chute arm at is maximum thickness. Once the sensor passes through, the cams contra-rotate back to their respective biased positions.

Abstract: The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

Abstract: The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

Abstract: In various embodiments, a tapered thread roll, a set of tapered thread rolls, a thread rolling tool, and a thread rolling method are provided for rolling angled or tapered threads onto a workpiece to create a threaded workpiece. In at least one embodiment, the threaded workpiece may comprise a polished rod or a polished rod precursor as specified by the American Petroleum Institute for use in an oil-field sucker-type pump, for example.

Abstract: This invention provides novel arylindenopyrimidines of the Formula (I), and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A1 and/or A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Abstract: The present invention is directed to pro-drugs of (E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pharmaceutical compositions containing them and the use of said pro-drugs and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes.

Abstract: A thread rolling die includes a thread rolling region comprising a working surface including a thread form. The thread rolling region of the thread rolling die comprises a sintered cemented carbide material having a hardness in the range of 78 HRA to 89 HRA. In certain embodiments, the thread rolling die may further include at least one non-cemented carbide piece metallurgically bonded to the thread rolling region in an area of the thread rolling region that does not prevent a workpiece from contacting the working surface, and wherein the non-cemented carbide piece comprises at least one of a metallic region and a metal matrix composite region. Methods of forming a thread rolling die as embodied herein are also disclosed.