Patents by Inventor Brian Shook

Brian Shook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200010459
    Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.
    Type: Application
    Filed: February 1, 2018
    Publication date: January 9, 2020
    Inventors: Maria VAN DONGEN, Jaroslaw JURASZEK, Griet Wim Bert SCHEPENS, Charles Edward LAWSON, Brian SHOOK, Maria Tim, Hugo JONCKERS, Abdellah TAHRI, Bernard Pierre, Jean-Marie RABOISSON, Nestor CHristophe, Francis, Robert BUYCK
  • Patent number: 9643236
    Abstract: A thread rolling die includes a thread rolling region comprising a working surface including a thread form. The thread rolling region of the thread rolling die comprises a sintered cemented carbide material having a hardness in the range of 78 HRA to 89 HRA. In certain embodiments, the thread rolling die may further include at least one non-cemented carbide piece metallurgically bonded to the thread rolling region in an area of the thread rolling region that does not prevent a workpiece from contacting the working surface, and wherein the non-cemented carbide piece comprises at least one of a metallic region and a metal matrix composite region. Methods of forming a thread rolling die as embodied herein are also disclosed.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: May 9, 2017
    Assignee: LANDIS SOLUTIONS LLC
    Inventors: Prakash K. Mirchandani, V. Brian Shook, Grayson L. Bowman, Matthew D. Brown
  • Patent number: 9045389
    Abstract: The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: June 2, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Devraj Chakravarty, Michael Greco, Brian Shook, Guozhang Xu, Rui Zhang
  • Patent number: 8748624
    Abstract: The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: June 10, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Devraj Chakravarty, Kevin Kreutter, Mark Powell, Brian Shook, Fengbin Song, Guozhang Xu, Shyh-Ming Yang, Rui Zhang, Bao-Ping Zhao
  • Patent number: 8726711
    Abstract: In various embodiments, a tapered thread roll, a set of tapered thread rolls, a thread rolling tool, and a thread rolling method are provided for rolling angled or tapered threads onto a workpiece to create a threaded workpiece. In at least one embodiment, the threaded workpiece may comprise a polished rod or a polished rod precursor as specified by the American Petroleum Institute for use in an oil-field sucker-type pump, for example.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: May 20, 2014
    Assignee: Kennametal Inc.
    Inventors: Terry L. Flegel, V. Brian Shook
  • Patent number: 8360685
    Abstract: An autonomous underwater plow can include a frame, a plow assembly and a propulsion assembly. The plow assembly is fixed to the one end of the frame, while the propulsion assembly is pivotably attached to the other end. The propulsion assembly includes thrusters that are rigidly coupled to a float, and that provide a propulsion force perpendicular to the float buoyancy force. The plow sinks when placed in the water, but the float provides sufficient buoyancy so that the float end floats while the plow end is in contact with the ocean floor. This establishes a rake angle of between the frame and ocean floor. The plow requires less propulsion force for motion because part of the plow is floating, and requires less force to overcome obstacles on the ocean floor because the thrusters provides a constant horizontal propulsion force while the frame tilts to overcome the obstacle.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: January 29, 2013
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Steve Whiteside, Robert Lee, Ronald Skala, Brian Shook, Paul Wade, Bret Thomson
  • Patent number: 8333535
    Abstract: An underwater plow includes a plow assembly that is attached to a frame. The plow assembly includes a blade portion, which defines a blade trough, and a sensor chute portion. The blade portion extends downwardly below a plane that is coincident with a longitudinal axis defined by the frame, while the chute portion extends upwardly above the same plane. A depressor arm is pivotably attached to the blade portion and biased to be in contact with the trough. The depressor arm has a groove that is sized to allow the cable, but not the sensors, to pass through the groove while the depressor arm is in contact with the trough. With this configuration, an array cable passes downward through the blade portion of the plow assembly and becomes buried in the ocean floor. Array sensors, however, are routed upward and pass through the chute portion of the plow assembly.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: December 18, 2012
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Steve Whiteside, Robert Lee, Ronald Skala, Brian Shook, Paul Wade, Bret Thomson
  • Patent number: 8328466
    Abstract: An underwater plow can include a depressor cam and a chute cam that are pivotably attached to a blade portion. The blade portion can be formed with a trough and the depressor cam can be biased in the trough. The chute cam can be formed with a groove having a minimum thickness at its attached end and an increasing taper to a maximum thickness at its distal end. A sensor passing through the plow contacts the edge of the depressor cam, causing depressor cam rotation away from the trough. The sensor passes the depressor cam and pushes against the chute cam, which causes the chute cam to contra-rotate relative to the depressor cam until the sensor passes through the chute arm at is maximum thickness. Once the sensor passes through, the cams contra-rotate back to their respective biased positions.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: December 11, 2012
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Brian Shook, Steve Whiteside, Robert Lee, Ronald Skala, Paul Wade, Bret Thomson
  • Publication number: 20120302641
    Abstract: The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 29, 2012
    Inventors: Devraj Chakravarty, Michael Greco, Brian Shook, Guozhang Xu, Rui Zhang
  • Publication number: 20120302610
    Abstract: The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 29, 2012
    Inventors: Devraj Chakravarty, Kevin Kreutter, Mark Powell, Brian Shook, Fengbin Song, Guozhang Xu, Shyh-Ming Yang, Rui Zhang, Bao-Ping Zhao
  • Publication number: 20120011912
    Abstract: In various embodiments, a tapered thread roll, a set of tapered thread rolls, a thread rolling tool, and a thread rolling method are provided for rolling angled or tapered threads onto a workpiece to create a threaded workpiece. In at least one embodiment, the threaded workpiece may comprise a polished rod or a polished rod precursor as specified by the American Petroleum Institute for use in an oil-field sucker-type pump, for example.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 19, 2012
    Applicant: TDY Industries, Inc.
    Inventors: Terry L. Flegel, V. Brian Shook
  • Publication number: 20110312956
    Abstract: This invention provides novel arylindenopyrimidines of the Formula (I), and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A1 and/or A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
    Type: Application
    Filed: June 16, 2010
    Publication date: December 22, 2011
    Inventors: Paul JACKSON, Brian SHOOK
  • Publication number: 20110172193
    Abstract: The present invention is directed to pro-drugs of (E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pharmaceutical compositions containing them and the use of said pro-drugs and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes.
    Type: Application
    Filed: January 3, 2011
    Publication date: July 14, 2011
    Inventors: Mark MACIELAG, Gary Eichenbaum, Tim Gaekens, Michel Guillaume, Brian Shook
  • Publication number: 20110107811
    Abstract: A thread rolling die includes a thread rolling region comprising a working surface including a thread form. The thread rolling region of the thread rolling die comprises a sintered cemented carbide material having a hardness in the range of 78 HRA to 89 HRA. In certain embodiments, the thread rolling die may further include at least one non-cemented carbide piece metallurgically bonded to the thread rolling region in an area of the thread rolling region that does not prevent a workpiece from contacting the working surface, and wherein the non-cemented carbide piece comprises at least one of a metallic region and a metal matrix composite region. Methods of forming a thread rolling die as embodied herein are also disclosed.
    Type: Application
    Filed: November 11, 2009
    Publication date: May 12, 2011
    Applicant: TDY Industries, Inc.
    Inventors: Prakash K. Mirchandani, V. Brian Shook, Grayson L. Bowman, Matthew D. Brown