Patents by Inventor Brian Shy

Brian Shy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR MODIFYING A TARGET NUCLEIC ACID
    Publication number: 20230159957
    Abstract: The disclosure provides compositions and methods for modifying a target nucleic acid that use a donor construct including at least one donor template comprising a single-stranded homology directed repair template (ssHDRT) and one or more DNA-binding protein target sequences, in which at least one DNA-binding protein target sequence forms a double-stranded duplex with a complementary polynucleotide sequence.
    Type: Application
    Filed: March 12, 2021
    Publication date: May 25, 2023
    Inventors: Alexander MARSON, Brian SHY, Jonathan ESENSTEN
  • COMPOSITIONS AND METHODS FOR MODIFYING A TARGET NUCLEIC ACID
    Publication number: 20230112075
    Abstract: The disclosure provides compositions and methods for for modifying an endogenous cell surface protein (e.g., an endogenous TCR) in a cell (e.g., a T cell) with a CAR or an exogenous protein (e.g., an exogenous intracellular or cell surface protein (e.g., an exogenous TCR)).
    Type: Application
    Filed: March 12, 2021
    Publication date: April 13, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alexander Marson, Brian Shy, Justin Eyquem, Vivasvan Vykunta