Abstract: Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.

Abstract: Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can he then removed under mild conditions to generate the target oligonucleotide in high purity.

Abstract: Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.

Abstract: Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.

Abstract: Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.

Abstract: Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.

Abstract: Among other things, this disclosure provides a method of detecting a target nucleic acid. Aspects of the method include: (a) obtaining a labeled nucleic acid probe that is complementary to a target nucleic acid, wherein the probe comprises a capture tag; (b) hybridizing the probe with the target nucleic in a fixed cell, in situ, to produce a duplex; (c) linking the probe in the duplex to a peroxidase conjugate via the capture tag to produce a peroxidase-labeled duplex; and (d) incubating the peroxidase-labeled duplex with a peroxidase substrate, wherein the peroxidase activity of the peroxidase conjugate catalyzes deposition of the substrate in the vicinity of the duplex, thereby producing a detectable signal.

Abstract: Among other things, this disclosure provides a method of detecting a target nucleic acid. Aspects of the method include: (a) obtaining a labeled nucleic acid probe that is complementary to a target nucleic acid, wherein the probe comprises a capture tag; (b) hybridizing the probe with the target nucleic in a fixed cell, in situ, to produce a duplex; (c) linking the probe in the duplex to a peroxidase conjugate via the capture tag to produce a peroxidase-labeled duplex; and (d) incubating the peroxidase-labeled duplex with a peroxidase substrate, wherein the peroxidase activity of the peroxidase conjugate catalyzes deposition of the substrate in the vicinity of the duplex, thereby producing a detectable signal.

Abstract: Method and filter for filtering a signal, in which the signal is applied to a delay line having a plurality of taps. Respective weighting coefficients of a windowing function are applied to outputs from the plurality of taps to thereby generate a plurality of weighted outputs. The method comprises repeatedly selecting, for output, whichever of the weighted outputs has the highest value.

Abstract: There is provided a femtocell device for use in connecting a mobile terminal to a communication network, the femtocell device comprising means for implementing a power control procedure in which a target value for a first characteristic of transmissions received from the mobile terminal is set and adjusted based on a quality of service criteria for the transmissions; and wherein the means for implementing the power control procedure operates in a physical layer of the femtocell device.

Abstract: Method and filter for filtering a signal, in which the signal is applied to a delay line having a plurality of taps. Respective weighting coefficients of a windowing function are applied to outputs from the plurality of taps to thereby generate a plurality of weighted outputs. The method comprises repeatedly selecting, for output, whichever of the weighted outputs has the highest value.

Abstract: There is provided a femtocell device for communicating with one or more user devices in a communication network, the network having a plurality of subchannels available for transmissions, wherein the femtocell device is adapted to use a first subset of the plurality of subchannels for communicating with user devices that are in a closed subscriber group of the femtocell device and within a first area, and a second subset of the plurality of subchannels for communicating with other user devices.

Abstract: There is provided a femtocell device for communicating with one or more user devices in a communication network, the network having a plurality of subchannels available for transmissions, wherein the femtocell device is adapted to use a first subset of the plurality of subchannels for communicating with user devices that are in a closed subscriber group of the femtocell device and within a first area, and a second subset of the plurality of subchannels for communicating with other user devices.

Abstract: There is provided a femtocell device for use in connecting a mobile terminal to a communication network, the femtocell device comprising means for implementing a power control procedure in which a target value for a first characteristic of transmissions received from the mobile terminal is set and adjusted based on a quality of service criteria for the transmissions; and wherein the means for implementing the power control procedure operates in a physical layer of the femtocell device.