Patents by Inventor Brian Sosa

Brian Sosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of ?v?6 integrin
    Patent number: 12552786
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: February 17, 2026
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Bryce A. Harrison, James E. Dowling, Aleksey I. Gerasyuto, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • Inhibitors of ?v?6 integrin
    Patent number: 12528803
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions. The small molecule inhibitors of ?v?6 integrin have a tetrahydroquinoline moiety linked by a -alkylene-CH(F)—, -alkylene-C(F)2—, -alkylene-CH(F)CH2—, -alkylene-C(F)2CH2—, -alkylene-O-alkylene-CH(F)—, or -alkylene-O-alkylene-C(F)2— to a pyrrolidine moiety.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: January 20, 2026
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Bryce A. Harrison, James E. Dowling, Aleksey I. Gerasyuto, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Cheng Zhong, Fu-Yang Lin, Brian Sosa, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • Inhibiting (?-v)(?-6) integrin
    Patent number: 12459942
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Grant
    Filed: January 8, 2024
    Date of Patent: November 4, 2025
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Bryce A. Harrison, James E. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Kristopher N. Hahn, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • Antagonists of human integrin ?4?7
    Patent number: 12221416
    Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.
    Type: Grant
    Filed: December 22, 2023
    Date of Patent: February 11, 2025
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Matthew G. Bursavich, Dawn M. Troast, Bryce A. Harrison, Blaise S. Lippa, Bruce N. Rogers, Kyle D. Konze, Aleksey I. Gerasyuto, Tyler Day, Fu-Yang Lin, Kristopher N. Hahn, Mats A. Svensson, Byungchan Kim, Cheng Zhong, Alexey A. Lugovskoy, Brian Sosa
  • INHIBITING (ALPHA-V)(BETA-6) INTEGRIN
    Publication number: 20240376095
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: January 8, 2024
    Publication date: November 14, 2024
    Inventors: Bryce A. Harrison, James E. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Kristopher N. Hahn, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7)
    Publication number: 20240294475
    Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.
    Type: Application
    Filed: December 22, 2023
    Publication date: September 5, 2024
    Inventors: Matthew G. Bursavich, Dawn M. Troast, Bryce A. Harrison, Blaise S. Lippa, Bruce N. Rogers, Kyle D. Konze, Aleksey I. Gerasyuto, Tyler Day, Fu-Yang Lin, Kristopher N. Hahn, Mats A. Svensson, Byungchan Kim, Cheng Zhong, Alexey A. Lugovskoy, Brian Sosa
  • Inhibiting (?-v)(?-6) integrin
    Patent number: 11739087
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: August 29, 2023
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Bryce A. Harrison, James E. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Kristopher N. Hahn, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN
    Publication number: 20230242524
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: October 17, 2022
    Publication date: August 3, 2023
    Inventors: Bryce A. Harrison, James E. Dowling, Aleksey I. Gerasyuto, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Cheng Zhong, Fu-Yang Lin, Brian Sosa, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN
    Publication number: 20230219949
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: October 19, 2022
    Publication date: July 13, 2023
    Inventors: Bryce A. Harrison, James E. Dowling, Aleksey I. Gerasyuto, Matthew M. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Tyler Day, Byungchan Kim, Kyle D. Konze
  • INHIBITORS OF AV ß6 INTEGRIN
    Publication number: 20230219947
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: October 17, 2022
    Publication date: July 13, 2023
    Inventors: Bryce A. Harrison, James E. Dowling, Aleksey I. Gerasyuto, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7)
    Publication number: 20220340529
    Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.
    Type: Application
    Filed: November 12, 2021
    Publication date: October 27, 2022
    Inventors: Matthew G. Bursavich, Dawn M. Troast, Bryce A. Harrison, Blaise S. Lippa, Bruce N. Rogers, Kyle D. Konze, Aleksey I. Gerasyuto, Tyler Day, Fu-Yang Lin, Kristopher N. Hahn, Mats A. Svensson, Byungchan Kim, Cheng Zhong, Alexey A. Lugovskoy, Brian Sosa
  • INHIBITING (ALPHA-V)(BETA-6) INTEGRIN
    Publication number: 20220073511
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: April 23, 2021
    Publication date: March 10, 2022
    Inventors: Bryce A. Harrison, James E. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Kristopher N. Hahn, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • Antagonists of human integrin (?4)(?7)
    Patent number: 11174228
    Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: November 16, 2021
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Matthew G. Bursavich, Dawn M. Troast, Bryce A. Harrison, Blaise S. Lippa, Bruce N. Rogers, Kyle D. Konze, Aleksey I. Gerasyuto, Tyler Day, Fu-Yang Lin, Kristopher N. Hahn, Mats A. Svensson, Byungchan Kim, Cheng Zhong, Alexey A. Lugovskoy, Brian Sosa
  • Inhibiting (?-V)(?-6) integrin
    Patent number: 11021480
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: June 1, 2021
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Bryce A. Harrison, James E. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato
  • ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7)
    Publication number: 20200385352
    Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.
    Type: Application
    Filed: July 27, 2020
    Publication date: December 10, 2020
    Inventors: Matthew G. Bursavich, Dawn M. Troast, Bryce A. Harrison, Blaise S. Lippa, Bruce N. Rogers, Kyle D. Konze, Aleksey I. Gerasyuto, Tyler Day, Fu-Yang Lin, Kristopher N. Hahn, Mats A. Svensson, Byungchan Kim, Cheng Zhong, Alexey A. Lugovskoy, Brian Sosa
  • INHIBITING (ALPHA-V)(BETA-6) INTEGRIN
    Publication number: 20200385384
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: August 24, 2020
    Publication date: December 10, 2020
    Inventors: Bryce A. Harrison, James J. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Kristopher N. Hahn, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • INHIBITING (ALPHA-V)(BETA-6) INTEGRIN
    Publication number: 20200354359
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: July 27, 2020
    Publication date: November 12, 2020
    Inventors: Bryce A. Harrison, James E. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Kristopher N. Hahn, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • Antagonists of human integrin ?4?7
    Patent number: 10759756
    Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: September 1, 2020
    Assignee: Morphic Therapeutic, Inc.
    Inventors: Matthew G. Bursavich, Dawn M. Troast, Bryce A. Harrison, Blaise S. Lippa, Bruce N. Rogers, Kyle D. Konze, Aleksey I. Gerasyuto, Tyler Day, Fu-Yang Lin, Kristopher N. Hahn, Mats A. Svensson, Byungchan Kim, Cheng Zhong, Alexey A. Lugovskoy, Brian Sosa
  • INHIBITING (ALPHA-V)(BETA-6) INTEGRIN
    Publication number: 20200071322
    Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.
    Type: Application
    Filed: August 29, 2019
    Publication date: March 5, 2020
    Inventors: Bryce A. Harrison, James E. Dowling, Matthew G. Bursavich, Dawn M. Troast, Blaise S. Lippa, Bruce N. Rogers, Kristopher N. Hahn, Cheng Zhong, Qi Qiao, Fu-Yang Lin, Brian Sosa, Aleksey I. Gerasyuto, Andrea Bortolato, Mats A. Svensson, Eugene Hickey, Kyle D. Konze, Tyler Day, Byungchan Kim
  • ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7)
    Publication number: 20190315692
    Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 17, 2019
    Inventors: Matthew G. Bursavich, Dawn M. Troast, Bryce A. Harrison, Blaise S. Lippa, Bruce N. Rogers, Kyle D. Konze, Aleksey I. Gerasyuto, Tyler Day, Fu-Yang Lin, Kristopher N. Hahn, Mats A. Svensson, Byungchan Kim, Cheng Zhong, Alexey A. Lugovskoy, Brian Sosa