Patents by Inventor Brian Springthorpe

Brian Springthorpe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel compounds
    Publication number: 20030144305
    Abstract: The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
    Type: Application
    Filed: December 20, 2002
    Publication date: July 31, 2003
    Applicant: AstraZeneca AB
    Inventors: David Hardern, Anthony Ingall, Brian Springthorpe, Paul Willis, Simon Guile
  • Triazolo(4,5-d)pyrimidine compounds
    Patent number: 6525060
    Abstract: Triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation. The compounds of the invention have the formula (I) as follows: wherein R, X and R1 through R3 are as defined in the specification.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: February 25, 2003
    Assignee: Astrazeneca UK Limited
    Inventors: David Hardern, Anthony Ingall, Brian Springthorpe, Paul Willis, Simon Guile
  • Bipiperidine derivatives as modulators of CCR3 activity and as H1 antagonists
    Patent number: 6525070
    Abstract: The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: February 25, 2003
    Assignee: AstraZeneca AB
    Inventors: Aaron Rigby, Hitesh Sanganee, Brian Springthorpe, Louise Lawrence
  • Chemical compounds
    Publication number: 20020077337
    Abstract: The present invention provides a compound of a formula (I): 1
    Type: Application
    Filed: April 6, 2001
    Publication date: June 20, 2002
    Inventors: Aaron Rigby, Hitesh Sanganee, Brian Springthorpe, Louise Lawrence
  • Triazolo(4,5-d)pyrimidine compounds
    Patent number: 6369064
    Abstract: Triazolo[4,5-d]pyrimidine compounds are provided of the formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification. Compositions containing the compounds are also provided, together with processes for their preparation and methods of use in the treatment of diseases, including myocardial infarction and unstable angina.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: April 9, 2002
    Assignee: AstraZeneca AB
    Inventors: Roger Brown, Garry Pairaudeau, Brian Springthorpe, Stephen Thom, Paul Willis
  • Triazolo[4,5-D]pyrimidinyl derivatives and their use as medicaments
    Patent number: 6297232
    Abstract: The invention relates to triazolo[4,5-d]pyrimidin-3-yl derivatives which are useful in the treatment of platelet aggregation disorders.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: October 2, 2001
    Assignee: AstraZeneca AB
    Inventors: Roger Victor Bonnert, Anthony Howard Ingall, Brian Springthorpe, Paul Andrew Willis
  • 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists
    Patent number: 6251910
    Abstract: Compounds of formula having the following stereochemistry wherein R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful as P2T receptor antagonists.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: June 26, 2001
    Assignee: AstraZeneca UK Limited
    Inventors: Simon Guile, Anthony Ingall, Brian Springthorpe, Paul Willis
  • Triazolo [4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation
    Patent number: 6156756
    Abstract: The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: December 5, 2000
    Assignee: AstraZeneca UK Limited
    Inventors: David Hardern, Brian Springthorpe
  • Substituted 3,4-dihydroxy phenylethylamino compounds
    Patent number: 4939147
    Abstract: Compounds of the formula, ##STR1## in which one of R.sub.30 and R.sub.40 represents a substituted phenylalkyl group and the other of R.sub.30 and R.sub.40 represents hydrogen or halogen, and R.sub.50 and R.sub.60 each independently represent hydrogen or alkyl.The compounds of the invention are useful for the treatment or prophylaxis of renal failure or cardiovascular disease.
    Type: Grant
    Filed: August 2, 1989
    Date of Patent: July 3, 1990
    Assignee: Fisons plc.
    Inventors: John Dixon, Brian Springthorpe, Francis Ince
  • Substituted 3,4-dihydroxy phenylethylamino compounds
    Patent number: 4922022
    Abstract: Novel compounds of the formula ##STR1## in which one of R.sub.30 and R.sub.40 represents a substituted phenylalkyl group,the other of R.sub.30 and R.sub.40 represents hydrogen or halogen, andR.sub.50 and R.sub.60 each independently represent hydrogen or alkyl; in addition R.sub.60 may represent a substituted alkyl chain interrupted by N.The compounds of the invention are useful for the treatment or prophylaxis of renal failure or cardiovascular disease.
    Type: Grant
    Filed: May 18, 1988
    Date of Patent: May 1, 1990
    Assignee: Fisons plc
    Inventors: John Dixon, Brian Springthorpe, Francis Ince
  • Aromatic compounds
    Patent number: 4883804
    Abstract: There are described compounds of formula I, ##STR1## in which X represents a C2 to 8 alkylene chain optionally interrupted by a double bond or by S(O).sub.n, wherein n is 0, 1 or 2;Y represents O or NH,l and m each independently represent 2, 3 or 4,R.sub.10 represents phenyl substituted by one or more substituents R.sub.23, which may be the same or different; or R.sub.10 represents pyridyl, a saturated carbocyclic group, alkyl C 1 to 6 or hydrogen,R.sub.15 represents hydrogen or together with R.sub.23 forms a (CH.sub.2).sub.p chain, wherein p represents 0, 1 or 2;R.sub.20, R.sub.21, R.sub.22 and R.sub.23, which may be the same or different, independently represent hydrogen, alkyl C 1 to 6, NHR.sub.25, SH, NO.sub.2, halogen, CF.sub.3, SO.sub.2 R.sub.30, CH.sub.2 OH or OH, wherein R.sub.25 represents hydrogen, alkyl C 1 to 6, alkanoyl C 1 to 6 or SO.sub.2 alkyl C 1 to 6, and R.sub.30 represents alkyl C 1 to 6 or NH.sub.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: November 28, 1989
    Assignee: Fisons plc
    Inventors: Francis Ince, Brian Springthorpe, John Dixon