Abstract: A tobacco pipe comprising a tobacco burning chamber, a stem having a bore communicating with the interior of the chamber, wherein the chamber comprises a brass musical instrument mouthpiece, and the stem comprises the lead tube of a brass musical instrument.

Abstract: A smoker's pipe, comprising a tobacco bowl for burning tobacco, and a stem extending from the outer bowl, wherein the bowl comprises a brass musical instrument mouthpiece and the stem comprises the lead tube of a brass musical instrument.

Abstract: The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.