Abstract: The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the IL1RL1 gene. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the IL1RL1 gene.

Abstract: An examining system includes one or more application devices onboard a vehicle system. The application devices may electrically conduct an examination signal into one or more conductive bodies extending along a route and may include a catenary, a third rail, and/or a cable. The examining system may include one or more detection units that may be disposed onboard the vehicle system and that may monitor one or more electrical characteristics of the one or more conductive bodies in response to the examination signal being conducted into the one or more conductive bodies. The examining system may include an identification unit that may examine the one or more electrical characteristics of the one or more conductive bodies monitored by the one or more detection units to identify a compromised or damaged section of the one or more conductive bodies.

Abstract: A system includes a route examining system and an off-board failsafe controller. The route examining system is configured to examine a route on which a first vehicle system is moving and to generate an inspection signal based on the route examination. The inspection signal indicates a status of a segment of the route as damaged or undamaged. The off-board failsafe controller is configured to receive the inspection signal from the route examining system. Responsive to a lack of receipt of the inspection signal within a designated time period which indicates communication loss with the route examining system, the failsafe controller is configured to generate a warning signal for communication to a second vehicle system. The warning signal is generated to direct the second vehicle system to (i) avoid traveling over the route segment or (ii) travel over the route segment or another route segment at a reduced speed.

Abstract: A system includes a route examining system and an off-board failsafe controller. The route examining system is configured to examine a route on which a first vehicle system is moving and to generate an inspection signal based on the route examination. The inspection signal indicates a status of a segment of the route as damaged or undamaged. The off-board failsafe controller is configured to receive the inspection signal from the route examining system. Responsive to a lack of receipt of the inspection signal within a designated time period which indicates communication loss with the route examining system, the failsafe controller is configured to generate a warning signal for communication to a second vehicle system. The warning signal is generated to direct the second vehicle system to (i) avoid traveling over the route segment or (ii) travel over the route segment or another route segment at a reduced speed.

Abstract: A system includes a route examining system on a non-propulsion-generating vehicle at a trailing end of a leading vehicle system. The route examining system examines a route on which the leading vehicle system is moving to determine whether the route is damaged. The system also includes an off-board failsafe controller that communicates with the route examining system. The off-board failsafe controller sends a warning signal to the trailing vehicle system responsive to receiving a notification signal from the route examining system indicating detection of damage to the route. The off-board failsafe controller also sends the warning signal to the trailing vehicle system responsive to losing communication with the route examining system. The warning signal directs the trailing vehicle system to automatically change movement of the trailing vehicle system responsive to the detection of damage to the route and/or the off-board failsafe controller losing communication with the route examining system.

Abstract: A system includes a route examining system on a non-propulsion-generating vehicle at a trailing end of a leading vehicle system. The route examining system examines a route on which the leading vehicle system is moving to determine whether the route is damaged. The system also includes an off-board failsafe controller that communicates with the route examining system. The off-board failsafe controller sends a warning signal to the trailing vehicle system responsive to receiving a notification signal from the route examining system indicating detection of damage to the route. The off-board failsafe controller also sends the warning signal to the trailing vehicle system responsive to losing communication with the route examining system. The warning signal directs the trailing vehicle system to automatically change movement of the trailing vehicle system responsive to the detection of damage to the route and/or the off-board failsafe controller losing communication with the route examining system.

Abstract: A system is provided for establishing a wireless-based communication link between a lead locomotive and a remote locomotive. A user on the lead locomotive is prompted to input a railroad and number identifier of the remote locomotive. A link command signal is transmitted from the lead locomotive, based on a predetermined number identifier of the lead locomotive, and the inputted railroad and number identifier. A second processor on the remote locomotive respectively compares the predetermined number identifier of the lead locomotive, the inputted railroad and number identifier of the lead locomotive, with an inputted number identifier of the lead locomotive, a predetermined railroad and a predetermined number identifier of the remote locomotive. A link reply signal, is transmitted from the remote locomotive, based on the comparison performed by the second processor, to establish the communication link. Additionally, a method is provided for establishing the wireless-based communication link.

Abstract: A system is provided for establishing a wireless-based communication link between a lead locomotive and a remote locomotive. A user on the lead locomotive is prompted to input a railroad and number identifier of the remote locomotive. A link command signal is transmitted from the lead locomotive, based on a predetermined number identifier of the lead locomotive, and the inputted railroad and number identifier. A second processor on the remote locomotive respectively compares the predetermined number identifier of the lead locomotive, the inputted railroad and number identifier of the lead locomotive, with an inputted number identifier of the lead locomotive, a predetermined railroad and a predetermined number identifier of the remote locomotive. A link reply signal, is transmitted from the remote locomotive, based on the comparison performed by the second processor, to establish the communication link. Additionally, a method is provided for establishing the wireless-based communication link.

Abstract: A method for controlling communications linking among locomotives includes determining, during a communications linking procedure between a first locomotive (e.g., 12, 36) and at least one of a second locomotive (e.g., 14, 32) and a third locomotive (e.g., 16, 38), that the second locomotive and the third locomotive have duplicate locomotive identifiers. The method further includes controlling an operation of the first locomotive responsive to a determination that the second locomotive and the third locomotive have duplicate locomotive identifiers.

Abstract: A method for automatically controlling a traction condition of a locomotive (16) configurable for operation by remote control includes establishing a communication link (18) between an operator control unit (12) offboard the locomotive and a remote control unit (14) onboard the locomotive to assert control of the locomotive. The method also includes sensing a loss of traction condition of the locomotive while the locomotive is being remotely operated. The method further includes automatically controlling an operation of the locomotive to correct the loss of traction condition.

Abstract: A system (10) and method for automatically controlling braking of a train (38). The method includes applying a first degree of braking to the train during a first period of time, and then applying a second degree of braking to the train during a second time period following the first time period so that the train is slowed in a manner effective to limit a peak deceleration rate experienced by the train. The system includes a sensor (36) providing a signal indicative of an operating condition of a locomotive of the train requiring braking of the train, a memory (22) storing a braking schedule, and a processor (18) comprising logic executable for accessing the braking schedule stored in the memory responsive to the signal to automatically control braking of the locomotive according to the schedule.

Abstract: A remote control system and method for the remote control operation of a locomotive in the performance of a car-kicking sequence comprises a portable control unit operable from a location off-board of the locomotive. The portable control unit includes an operator interface allowing an operator to initiate, with a single step, a predetermined sequence of locomotive operations for automatically performing a car-kicking procedure and generating a signal responsive to the single step for transmission to the locomotive. The system also includes a memory for storing a set of instructions corresponding to the predetermined sequence. An onboard slave control unit, interfaced with an operating system on the locomotive, receives the signal and automatically controls movement of the locomotive according to the set of instructions.

Abstract: A railway communication system (10) includes a transmitter (12) receiving an input and producing a communication signal (18). The communication signal (18) includes at least two different portions (20,22) for separately encoding respective indications (38,40) of the input. The system also includes a receiver (14) coupled to a controlled device, the receiver (14) extracting at least one of the respective indications (38,40) from the communication signal (18). The receiver controls the device responsive to the at least one extracted indications (38,40).