Abstract: In one aspect, systems for storing and/or transporting a payload are described herein. In some embodiments, systems have a portable storage vessel having an internal cavity, the internal cavity having: a central zone for receiving the payload; a first cooling zone disposed radially outward from the central recess, with a first phase change material disposed in the first cooling zone; a second cooling zone disposed radially outward from the first cooling zone, with a second phase change material disposed in the second cooling zone, wherein the first phase change material has a first phase transition temperature; wherein the second phase change material has a second phase transition temperature; and wherein the second phase transition temperature is between 10° C. and 15° C. higher than the first phase transition temperature; and wherein each of the first phase transition temperature and the second phase transition temperature are below 0° C.