Patents by Inventor Brian Stoltz

Brian Stoltz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ASCAROSIDE MODIFICATION OF MAMMALIAN MICROBIOTA
    Publication number: 20220409650
    Abstract: Described herein are composition of ascarosides, methods of using them, and the like for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for modifying a microbiome of a patient (e.g., for treatment of gut microbiome dysfunction).
    Type: Application
    Filed: June 3, 2020
    Publication date: December 29, 2022
    Inventors: Andrea Choe, Brian Stoltz, Simon Bailey, Eduardo Martinez
  • TOTAL SYNTHESIS OF PROSTAGLANDIN J NATURAL PRODUCTS BY TEREORETENTIVE METATHESIS
    Publication number: 20210332011
    Abstract: This invention relates generally to the synthesis of ?12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. ?12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).
    Type: Application
    Filed: May 14, 2019
    Publication date: October 28, 2021
    Inventors: Jiaming LI, Xu CHEN, Tonia S. AHMED, Brian STOLTZ, Robert H. GRUBBS
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
    Publication number: 20110312975
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
    Type: Application
    Filed: June 21, 2011
    Publication date: December 22, 2011
    Inventors: Zhe Yang, Scott Collibee, Alex R. Muci, Jianchao Wang, Luke W. Ashcraft, Jeff Gardina, Brian Stoltz, Gustave Bergnes, Bradley P. Morgan
  • Certain chemical entities, compositions, and methods
    Patent number: 7989469
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: August 2, 2011
    Assignee: Cytokinetics, Incorporated
    Inventors: Zhe Yang, Scott Collibee, Alex R. Muci, Jianchao Wang, Luke W. Ashcraft, Jeff Gardina, Brian Stoltz, Gustave Bergnes, Bradley P. Morgan
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
    Publication number: 20090253737
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
    Type: Application
    Filed: February 2, 2009
    Publication date: October 8, 2009
    Inventors: Zhe YANG, Scott COLLIBEE, Alex MUCI, Jianchao WANG, Luke W. ASHCRAFT, Jeff GARDINA, Brian STOLTZ, Gustave BERGNES, Bradley P. MORGAN
  • Enantioselective, catalytic allylation of ketones and olefins
    Publication number: 20060084820
    Abstract: Compounds containing a substituted or unsubstituted allyl group directly bound to a chiral carbon atom are prepared enantioselectively. Starting reactants are either chiral or achiral, and may or may not contain an attached allyloxycarbonyl group as a substituent. Chiral ligands are employed, along with transition metal catalysts. The methods of the invention are effective in providing enantioconvergent allylation of chiral molecules.
    Type: Application
    Filed: August 29, 2005
    Publication date: April 20, 2006
    Applicant: California Institute of Technology
    Inventors: Douglas Behenna, Brian Stoltz, Justin Mohr, Andrew Harned
  • Chemical reagents capable of selective attachment to and reaction with peptides and proteins
    Publication number: 20050010059
    Abstract: Biomimetic reagents capable of selectively forming non-covalent complexes and initiating intermolecular reactions with peptides in the gas phase are described. The reagents are particularly useful in gas phase peptides chemistry.
    Type: Application
    Filed: February 18, 2004
    Publication date: January 13, 2005
    Inventors: Jesse Beauchamp, Ryan Julian, Brian Stoltz, Jeremy May