Patents by Inventor Brian T. Wimberly

Brian T. Wimberly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimicrobial compounds and methods of making and using the same
    Patent number: 10259825
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: April 16, 2019
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco Devivo, Rongliang Lou, Brian T. Wimberly
  • Antimicrobial Compounds And Methods Of Making And Using The Same
    Publication number: 20180334439
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: December 18, 2017
    Publication date: November 22, 2018
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco Devivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • Antimicrobial compounds and methods of making and using the same
    Patent number: 9845297
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 19, 2017
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • Antimicrobial Compounds And Methods Of Making And Using The Same
    Publication number: 20170320892
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: January 5, 2017
    Publication date: November 9, 2017
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco Devivo, Rongliang Lou, Brian T. Wimberly
  • Antimicrobial compounds and methods of making and using the same
    Patent number: 9573962
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: February 21, 2017
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco DeVivo, Rongliang Lou, Brian T. Wimberly
  • ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20160031893
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: October 12, 2015
    Publication date: February 4, 2016
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Zoltan F. Kanyo, Jacek G. Martinow, Ik-Hyeon Paik, Matthew H. Scheideman, Sandra Sinishtaj, Brian T. Wimberly, Yusheng Wu
  • ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20160031828
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: October 16, 2015
    Publication date: February 4, 2016
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • Antimicrobial compounds and methods of making and using the same
    Patent number: 9216979
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: December 22, 2015
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • Antimicrobial compounds and methods of making and using the same
    Patent number: 9193731
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: November 24, 2015
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Zoltan F. Kanyo, Jacek G. Martinow, Ik-Hyeon Paik, Matthew H. Scheideman, Sandra Sinishtaj, Brian T. Wimberly, Yusheng Wu
  • ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20150274752
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: April 8, 2015
    Publication date: October 1, 2015
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco DeVivo, Rongliang Lou, Brian T. Wimberly
  • Antimicrobial compounds and methods of making and using the same
    Patent number: 9023843
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: May 5, 2015
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco DeVivo, Rongliang Lou, Brian T. Wimberly
  • PROTEIN SYNTHESIS MODULATORS
    Publication number: 20130344562
    Abstract: The invention provides a high resolution three-dimensional structure of cycloheximide, either alone or in association with a large ribosomal subunit. The invention provides methods for designing and/or identifying cycloheximide analogs and derivatives that bind and/or modulate the protein biosynthetic activity of the ribosome.
    Type: Application
    Filed: February 11, 2013
    Publication date: December 26, 2013
    Applicant: RIB-X PHARMACEUTICALS, INC.
    Inventor: Brian T. Wimberly
  • Protein synthesis modulators
    Patent number: 8428884
    Abstract: The invention provides a high resolution three-dimensional structure of a deacylated transfer RNA protein synthesis modulator in association with a large ribosomal subunit. The protein synthesis modulator binds at least a portion of the E-site of a large ribosomal subunit. The invention provides methods for designing and/or identifying analogs of candidate molecules, for example, analogs or derivatives of the protein synthesis modulator, that bind and/or modulate the protein biosynthetic activity of the ribosome.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: April 23, 2013
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventor: Brian T. Wimberly
  • Antimicrobial Compounds and Methods of Making and Using the Same
    Publication number: 20130090326
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 11, 2013
    Applicant: Rib-X Pharmaceuticals, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
  • Protein synthesis modulators
    Patent number: 8374794
    Abstract: The invention provides a high resolution three-dimensional structure of cycloheximide, either alone or in association with a large ribosomal subunit. The invention provides methods for designing and/or identifying cycloheximide analogs and derivatives that bind and/or modulate the protein biosynthetic activity of the ribosome.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: February 12, 2013
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventor: Brian T. Wimberly
  • Antimicrobial Compounds and Methods of Making and Using the Same
    Publication number: 20120220566
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: October 15, 2010
    Publication date: August 30, 2012
    Applicant: Rib-X Pharmaceuticals, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Zoltan F. Kanyo, Jacek G. Martinow, Ik-Hyeon Paik, Matthew H. Scheideman, Sandra Sinishtaj, Brian T. Wimberly, Yusheng Wu
  • Antimicrobial Compounds and Methods of Making and Using the Same
    Publication number: 20120202792
    Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
    Type: Application
    Filed: October 15, 2010
    Publication date: August 9, 2012
    Applicant: Rib-X Pharmaceuticals, Inc.
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Shili Chen, Marco DeVivo, Rongliang Lou, Brian T. Wimberly
  • Screening methods using the crystal structure of ribosomal protein L11/GTPase activating region rRNA complex
    Patent number: 6845328
    Abstract: The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: January 18, 2005
    Assignee: University of Utah Research Foundation
    Inventors: Brian T. Wimberly, Venkatraman Ramakrishnan
  • Crystal structure of ribosomal protein L11/GTPase activating region rRNA and uses thereof
    Publication number: 20030099955
    Abstract: The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.
    Type: Application
    Filed: November 1, 2001
    Publication date: May 29, 2003
    Inventors: Brian T. Wimberly, Venkatraman Ramakrishnan