Abstract: Provided are beneficial and therapeutic Amanita muscaria compositions. In some embodiments, the provided A. muscaria compositions comprise A. muscaria extracts. In some embodiments, the provided A. muscaria compositions comprise one or more compounds from A. muscaria such as muscimol and muscarine, as well as analogs thereof. In some aspects, the provided A. muscaria compositions are used to promote health and wellness, such as to enhance calmness in a subject. In some aspects, the provided A. muscaria compositions are used to treat mental health conditions and physical health conditions in a subject.

Abstract: Disclosed herein are methods of muscimol extraction from Amanita mushrooms, and more particularly, enhanced muscimol extraction processes from Amanita muscaria, including by distillation, refluxing, and pressing, including processes that increase muscimol content and decrease ibotenic acid content, and which provide liquid and powder extracts useful in preparations for human health.