Patents by Inventor Brian Thomas Gregg

Brian Thomas Gregg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof
    Patent number: 10597401
    Abstract: The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: March 24, 2020
    Assignee: Albany Molecular Research, Inc.
    Inventors: Robert Jason Herr, Brian Thomas Gregg, William Bert Geiss
  • METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF
    Publication number: 20180134724
    Abstract: The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.
    Type: Application
    Filed: May 5, 2016
    Publication date: May 17, 2018
    Inventors: Robert Jason HERR, Brian Thomas GREGG, William Bert GEISS
  • Synthesis of racemic amphetamine derivatives by cuprate addition reaction with aziridine phosphoramidate compounds
    Patent number: 9321794
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: April 26, 2016
    Assignee: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Synthesis of chiral amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds
    Patent number: 9278904
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: March 8, 2016
    Assignee: Chemapotheca, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Synthesis of Racemic Amphetamine Derivatives by Cuprate Addition Reaction with Aziridine Phosphoramidate Compounds
    Publication number: 20150183810
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Application
    Filed: July 9, 2014
    Publication date: July 2, 2015
    Applicant: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Synthesis of Chiral Amphetamine Derivatives by Stereospecific, Regioselective Cuprate Addition Reaction with Aziridine Phosphoramidate Compounds
    Publication number: 20150183716
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,
    Type: Application
    Filed: February 25, 2014
    Publication date: July 2, 2015
    Applicant: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang