Abstract: In some examples, the techniques and systems described herein relate to generating a patient-specific drug-response prediction. For example, the technique may involve generating a drug-response expression profile corresponding to an efficacious therapeutic effect of a drug based on analysis of gene-expression and drug-response data stored in a database for one or more cell lines. The technique may also involve comparing a gene-expression profile of a patient tumor to the drug-response expression profile in order to generate a report of a patient-specific drug-response prediction. The report of the patient-specific drug-response prediction may identify one or more drugs likely to have an efficacious therapeutic effect on the patient tumor.

Abstract: A method to predict the response. e.g., a strong positive response or a strong lack of responsive, of myeloma cells of a multiple myeloma patient to a proteasome inhibitor is provided.

Abstract: Transgenic non-human animals with expanded mature B cell and plasma cell populations are described, as well as methods of using the transgenic non-human animals to screen for pharmaceutically active agents and to produce targeted antibodies.