Abstract: One aspect of the disclosure is an exterior cladding panel including one or more courses of simulated shingles, a locking clip extending from a front face of the exterior cladding panel, and a locking leg extending from a rear face of the exterior cladding panel. The exterior cladding panel also includes a first plurality of tabs extending from a top edge of the exterior cladding panel, where each tab in the first plurality of tabs includes at least one projection extending approximately perpendicular to the front face. A respective top end of each tab in the first plurality of tabs extends a common distance from the top edge of the exterior cladding panel. A second plurality of tabs extends from the top edge of the exterior cladding panel, where a respective top end of each tab in the second plurality of tabs extends the common distance from the top edge.

Abstract: The present invention is directed to methods of treating a human for a variety of conditions by administering an agonist of the G protein coupled receptor TGR5. In addition, the invention includes methods for determining whether a test compound is likely to be effective in treating one of these conditions by assaying it for its ability to raise intracellular iodothyronine deiodinase levels or for its ability to bind to and activate TGR5.