Patents by Inventor Brian W. O'MARA

Brian W. O'MARA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of antibody production that minimize disulfide bond reduction
    Patent number: 11760777
    Abstract: The present disclosure discloses methods for purifying antibodies providing an air overlay or headspace to single-use storage bags containing the antibody during purification. In specific embodiments, the application relates to purification of antibodies to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), such as antibody 22G2, which decrease unwanted disulfide bond reduction. The application further provides depth filtration at lower throughput and/or flux, which also minimizes unwanted disulfide bond reduction.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: September 19, 2023
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: John C. Fann, Brian W. O'Mara, Laura R. Smith
  • IMPROVED METHODS OF ANTIBODY PRODUCTION THAT MINIMIZE DISULFIDE BOND REDUCTION
    Publication number: 20200181193
    Abstract: The present disclosure discloses methods for purifying antibodies providing an air overlay or headspace to single-use storage bags containing the antibody during purification. In specific embodiments, the application relates to purification of antibodies to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), such as antibody 22G2, which decrease unwanted disulfide bond reduction. The application further provides depth filtration at lower throughput and/or flux, which also minimizes unwanted disulfide bond reduction.
    Type: Application
    Filed: April 24, 2018
    Publication date: June 11, 2020
    Inventors: John C. FANN, Brian W. O'MARA, Laura R. SMITH