Abstract: Drug delivery hubs are described herein. The drug delivery hub includes a hub housing, a reservoir, a nebulizer channel, and a gas channel. The hub housing defines a housing volume. The hub housing is configured to directly couple with a mask defining a patient cavity. The reservoir is disposed at least partially within the housing volume. The reservoir includes a reservoir volume configured to dispense a medicament. The nebulizer channel is in fluid communication with the reservoir volume and configured to be in fluid communication with the patient cavity when the hub is coupled with the mask. The gas channel is in fluid communication with the nebulizer channel. The gas channel is configured to direct a gas flow toward the patient cavity through the nebulizer channel, drawing a portion of the medicament from the reservoir through the nebulizer channel with the gas flow toward the patient cavity.

Abstract: A patient nasal interface is provided that includes a female portion and a first registration feature. The female portion receives a male portion of a generator head. The female portion wraps around and over the male portion when the male portion is inserted into the female portion of the patient nasal interface. The first registration feature is configured for mating with a second registration feature associated with the male portion of the generator head and wherein the mating of the first registration feature with the second registration feature provides a feedback to an operator upon proper insertion of the male portion into the female portion.

Abstract: A pressure relief device comprising a valve configured to resiliently deform in response to a predetermined pressure; and a sound dampener configured to dampen a sound generated by the valve when the valve resiliently deforms in response to the predetermined pressure.

Abstract: A patient nasal interface is provided that includes a female portion and a first registration feature. The female portion receives a male portion of a generator head. The female portion wraps around and over the male portion when the male portion is inserted into the female portion of the patient nasal interface. The first registration feature is configured for mating with a second registration feature associated with the male portion of the generator head and wherein the mating of the first registration feature with the second registration feature provides a feedback to an operator upon proper insertion of the male portion into the female portion.

Abstract: A patient nasal interface is provided that includes a female portion and a first registration feature. The female portion receives a male portion of a generator head. The female portion wraps around and over the male portion when the male portion is inserted into the female portion of the patient nasal interface. The first registration feature is configured for mating with a second registration feature associated with the male portion of the generator head and wherein the mating of the first registration feature with the second registration feature provides a feedback to an operator upon proper insertion of the male portion into the female portion.

Abstract: A pressure relief device comprising a valve configured to resiliently deform in response to a predetermined pressure; and a sound dampener configured to dampen a sound generated by the valve when the valve resiliently deforms in response to said predetermined pressure.

Abstract: A pressure relief device comprising a valve configured to resiliently deform in response to a predetermined pressure; and a sound dampener configured to dampen a sound generated by the valve when the valve resiliently deforms in response to said predetermined pressure.

Abstract: A pressure relief device comprising a valve configured to resiliently deform in response to a predetermined pressure; and a sound dampener configured to dampen a sound generated by the valve when the valve resiliently deforms in response to said predetermined pressure.

Abstract: A carbon-dioxide sampling system for accurately monitoring carbon dioxide in exhaled breath. The system includes a ventilator. The ventilator is configured to ventilate a patient with respiratory gases. The ventilator includes a carbon-dioxide sampling control unit and a carbon-dioxide analyzer. The carbon-dioxide sampling control unit is configured to control the timing of sampling of carbon dioxide in the exhaled breath of a patient, and to control the timing of the analysis of exhaled gases by the carbon-dioxide analyzer.

Abstract: A non-invasive ventilation patient interface comprises a fresh gas entry port, an exhaust gas vent port, and a filter media disposed in the exhaust gas vent port. The fresh gas entry port is configured for coupling with a fresh gas supply. The exhaust gas vent port is configured for allowing expulsion of exhaust gas from the patient interface in response to exhalation of a patient. The filter media is configured for filtering contagious from the exhaust gas, diffusing the exhaust gas, and controlling an expulsion flow of the exhaust gas through the exhaust gas vent port.

Abstract: A non-invasive ventilation patient interface comprises a fresh gas entry port, an exhaust gas entry port, and a facial skin interface. Fresh gas entry port is configured for coupling with a fresh gas supply. The exhaust gas vent port is configured for allowing expulsion of exhaust gas from the patient interface. The facial skin interface is configured for eliminating fluid from within the patient interface and for eliminating fluid from facial skin which is covered by the patient interface.

Abstract: A mask for patient ventilation comprises a frame portion, a front portion, a retention strap, and a gas delivery orifice. The frame portion is for surrounding a respiratory opening of a patient. The front portion is coupled with the frame portion and covers the respiratory opening region. The retention strap is for maintaining positive pressure between the frame portion and the patient. The gas delivery orifice is coupled with the frame portion and configured such that the gas delivery orifice is lateral to the front portion.

Abstract: In a method for adjusting a ventilation mask, a ventilative state is measured of a ventilation mask that is placed over a respiratory opening of a patient. A sealing portion of the ventilation mask is for establishing a fluid seal between the ventilation mask and the patient. The sealing portion comprises a plurality of bladders. An unintentional leak of the fluid seal is determined based on a measured change of the ventilative state. A bladder of the plurality of bladders is adjusted to seal the unintentional leak.

Abstract: In a mask for patient ventilation, a frame portion is included for surrounding a respiratory opening of a patient. A retention strap is coupled with the frame portion for maintaining positive pressure between the frame portion and the respiratory opening of the patient. A removable insert is configured to physically attach and detach from the frame portion without requiring removal of the frame or the retention strap from the patient.

Abstract: A system for reducing sound level in a respiratory gas delivery system is described. The system includes an exhaust portion and a sound reducing component that is coupled with the exhaust portion and is configured for absorbing sound. The sound reducing component includes a pathway through which air from within the exhaust portion may move.

Abstract: A system for reducing sound level in a respiratory gas delivery system is described. The system includes a first portion of a breathing circuit tubing and a second portion of the breathing circuit tubing positioned in-line with the first portion, wherein the second portion of the breathing circuit tubing is a sound-reducing tubing.

Abstract: A patient nasal interface is provided that includes a female portion and a first registration feature. The female portion receives a male portion of a generator head. The female portion wraps around and over the male portion when the male portion is inserted into the female portion of the patient nasal interface. The first registration feature is configured for mating with a second registration feature associated with the male portion of the generator head and wherein the mating of the first registration feature with the second registration feature provides a feedback to an operator upon proper insertion of the male portion into the female portion.

Abstract: In a mask for patient ventilation, a frame portion is included for surrounding a respiratory opening of a patient. A retention strap is coupled with the frame portion for maintaining positive pressure between the frame portion and the respiratory opening of the patient. A removable insert is configured to physically attach and detach from the frame portion without requiring removal of the frame or the retention strap from the patient.

Abstract: A non-invasive ventilation patient interface comprises a fresh gas entry port, an exhaust gas vent port, and a filter media disposed in the exhaust gas vent port. The fresh gas entry port is configured for coupling with a fresh gas supply. The exhaust gas vent port is configured for allowing expulsion of exhaust gas from the patient interface in response to exhalation of a patient. The filter media is configured for filtering contagious from the exhaust gas, diffusing the exhaust gas, and controlling an expulsion flow of the exhaust gas through the exhaust gas vent port.

Abstract: In a method for adjusting a ventilation mask, a ventilative state is measured of a ventilation mask that is placed over a respiratory opening of a patient A sealing portion of the ventilation mask is for establishing a fluid seal between the ventilation mask and the patient. The sealing portion comprises a plurality of bladders. An unintentional leak of the fluid seal is determined based on a measured change of the ventilative state. A bladder of the plurality of bladders is adjusted to seal the unintentional leak.