Patents by Inventor Brian Wamhoff
Brian Wamhoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220142955Abstract: The present disclosure relates to methods of treating organic acidemias. In some embodiments, the methods comprise reducing propionyl-CoA, isovaleryl-CoA and methylmalonyl-CoA production, and various related metabolites, in a subject in need thereof.Type: ApplicationFiled: March 13, 2020Publication date: May 12, 2022Inventors: Brian WAMHOFF, John REARDON, Robert FIGLER
-
Patent number: 9770349Abstract: The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one dealloyed nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.Type: GrantFiled: May 24, 2007Date of Patent: September 26, 2017Assignee: University of Virginia Patent FoundationInventors: Gary Owens, Whye-Kei Lye, Michael Reed, Joshua Spradlin, Brian Wamhoff, Matthew Hudson, Kareen Looi
-
Patent number: 8124166Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: GrantFiled: February 23, 2010Date of Patent: February 28, 2012Assignee: Medtronic Vascular, Inc.Inventors: Gary Owens, Brian Wamhoff, Matthew S. Hudson, Whye-Kei Lye, Joshua Spradlin, Michael Reed, Kareen Looi
-
Publication number: 20080086198Abstract: The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.Type: ApplicationFiled: May 24, 2007Publication date: April 10, 2008Inventors: Gary Owens, Whye-Kei Lye, Michael Reed, Joshua Spradlin, Brian Wamhoff, Matthew Hudson, Kareen Looi
-
Publication number: 20060276879Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy.Type: ApplicationFiled: May 11, 2006Publication date: December 7, 2006Inventors: Whye-Kei Lye, Michael Reed, Gary Owens, Brian Wamhoff, Joshua Spradlin, Matthew Hudson
-
Publication number: 20060276885Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: May 10, 2006Publication date: December 7, 2006Inventors: Whye-Kei Lye, Gary Owens, Michael Reed, Brian Wamhoff, Kareen Looi, Joshua Spradlin
-
Publication number: 20060276877Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: May 9, 2006Publication date: December 7, 2006Inventors: Gary Owens, Whye-Kei Lye, Michael Reed, Joshua Spradlin, Brian Wamhoff, Matthew Hudson, Kareen Looi
-
Publication number: 20060276884Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: May 10, 2006Publication date: December 7, 2006Inventors: Whye-Kei Lye, Gary Owens, Brian Wamhoff, Michael Reed, Kareen Looi, Joshua Spradlin
-
Publication number: 20060276878Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: May 9, 2006Publication date: December 7, 2006Inventors: Gary Owens, Whye-Kei Lye, Michael Reed, Joshua Spradlin, Brian Wamhoff, Matthew Hudson, Kareen Looi
-
Publication number: 20060193890Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: February 10, 2006Publication date: August 31, 2006Inventors: Gary Owens, Brian Wamhoff, Matthew Hudson, Whye-Kei Lye, Joshua Spradlin, Michael Reed, Kareen Looi
-
Publication number: 20060193886Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: February 10, 2006Publication date: August 31, 2006Inventors: Gary Owens, Whye-Kei Lye, Matthew Hudson, Brian Wamhoff, Joshua Spradlin, Kareen Looi
-
Publication number: 20060193887Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: February 10, 2006Publication date: August 31, 2006Inventors: Gary Owens, Brian Wamhoff, Matthew Hudson, Whye-Kei Lye, Joshua Spradlin, Kareen Looi
-
Publication number: 20060193888Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.Type: ApplicationFiled: February 10, 2006Publication date: August 31, 2006Inventors: Whye-Kei Lye, Gary Owens, Brian Wamhoff, Matthew Hudson, Joshua Spradlin, Kareen Looi
-
Publication number: 20050070989Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy.Type: ApplicationFiled: August 13, 2004Publication date: March 31, 2005Inventors: Whye-Kei Lye, Michael Reed, Gary Owens, Brian Wamhoff, Matthew Hudson, Kareen Looi