Patents by Inventor Brian Warner
Brian Warner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11957502Abstract: A radiographic imaging system having a number of useable digital radiographic detectors selectively activates one of the detectors to capture a radiographic image. The DR detectors each include a movement detector configured to transmit a movement signal when a movement of the corresponding detector is sensed. A portion of the system is disabled in response to receiving a movement signal transmitted from a motion sensor in a detector other than the active detector.Type: GrantFiled: December 13, 2021Date of Patent: April 16, 2024Assignee: Carestream Health, Inc.Inventors: Brandon McComber, Brian M. Colwell, Damon Wilkins, Scott Warner
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Patent number: 8063196Abstract: The invention provides a set of highly orthogonal six-code universal sequences for use in bDNA singleplex and multiplex nucleic acid hybridization assays. The six-code orthogonal sequences do not cross-hybridize and thus, minimize or eliminate the 3-mer cross-hybridization inherent in the second and third generation bDNA assays. The highly orthogonal universal sequences may be used in singleplex or multiplex bDNA assays quantitatively and qualitatively to determine mRNA levels in a sample; to screen for and genotype targets, such as viruses, that are present in low volumes in a sample; to screen for and genotype SNPs; and to measure changes in the amount of a gene in a sample such as when gene amplifications or deletions occur. The highly orthogonal universal sequences may also be used as universal capture probes to selectively bind assay components in a way that facilitates their further analysis.Type: GrantFiled: February 1, 2005Date of Patent: November 22, 2011Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Minxue Zheng, David Ahle, Brian Warner, Ming Wu, Chu-an Chang
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Patent number: 7708242Abstract: A bucket holding apparatus includes first and second carriages with pivotally attached inner edges arranged in such a manner that the first and second carriages freely rotate upwardly from a horizontal plane defined on a support surface. The bucket holding apparatus further includes first and second arcuate walls directly conjoined to the first and second carriages and oppositely situated from the inner edges such that the first and second arcuate walls define a circular cavity within a combined perimeter thereof. The bucket holding apparatus further includes an arcuate lever directly and statically conjoined to the second carriage and extending laterally upwards away from an outer edge thereof.Type: GrantFiled: September 10, 2007Date of Patent: May 4, 2010Inventors: Chris Petrashune, Michael Cordeaux, Brian Warner
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Publication number: 20070231821Abstract: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.Type: ApplicationFiled: February 23, 2007Publication date: October 4, 2007Inventors: Charles Bupp, K. Choi, Rachel Holmes-Davis, Alexander Izmailov, Heather Koshinsky, Christopher Nulf, Mickey Urdea, Miaomiao Wang, Brian Warner, Michael Zwick
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Publication number: 20060172284Abstract: The invention provides a set of highly orthogonal six-code universal sequences for use in bDNA singleplex and multiplex nucleic acid hybridization assays. The six-code orthogonal sequences do not cross-hybridize and thus, minimize or eliminate the 3-mer cross-hybridization inherent in the second and third generation bDNA assays. The highly orthogonal universal sequences may be used in singleplex or multiplex bDNA assays quantitatively and qualitatively to determine mRNA levels in a sample; to screen for and genotype targets, such as viruses, that are present in low volumes in a sample; to screen for and genotype SNPs; and to measure changes in the amount of a gene in a sample such as when gene amplifications or deletions occur. The highly orthogonal universal sequences may also be used as universal capture probes to selectively bind assay components in a way that facilitates their further analysis.Type: ApplicationFiled: February 1, 2005Publication date: August 3, 2006Applicant: Bayer HealthCare LLCInventors: Minxue Zheng, David Ahle, Brian Warner, Ming Wu, Chu-an Chang
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Publication number: 20060105337Abstract: The invention relates to methods for detection of nucleic acids on a solid phase, combining high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization with highly specific enzymatic discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays.Type: ApplicationFiled: August 29, 2003Publication date: May 18, 2006Inventors: Brian Warner, Jack Quinn, Jens Burmeister, Ingmar Dorn, Edgar Diessel
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Publication number: 20040137468Abstract: The invention relates to methods for detection of nucleic acids on a solid phase, combining high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization with highly specific enzymatic discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays.Type: ApplicationFiled: August 29, 2003Publication date: July 15, 2004Inventors: Brian Warner, John Quinn, Jens Burmeister, Ingmar Dorn, Edgar Diessel
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Patent number: 5849481Abstract: Comb-type branched polynucleotides are used as amplification multimers in nucleic acid hybridization assays.Type: GrantFiled: June 5, 1995Date of Patent: December 15, 1998Assignee: Chiron CorporationInventors: Michael S. Urdea, Thomas Horn, Chu-An Chang, Brian Warner, Timothy J. Fultz
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Patent number: 5710264Abstract: Large comb-type branched polynucleotides useful as amplifier molecules in nucleic acid hybridization assays are provided, the polynucleotides comprising: a polynucleotide backbone having at least about 15 multifunctional nucleotides, each of which defines a sidechain site and a first single-stranded oligonucleotide unit that is capable of binding specifically to a first single-stranded polynucleotide sequence of interest; and pendant polynucleotide sidechains extending from said multifunctional nucleotides each comprising iterations of a second single-stranded oligonucleotide unit that is capable of binding specifically to a second single-stranded polynucleotide sequence of interest, the total number of iterations in all sidechains being at least 20. Methods of making these polynucleotides are also provided.Type: GrantFiled: June 7, 1995Date of Patent: January 20, 1998Assignee: Chiron CorporationInventors: Michael S. Urdea, Thomas Horn, Chu-An Chang, Brian Warner, Timothy J. Fultz
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Patent number: 5624802Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.Type: GrantFiled: June 7, 1995Date of Patent: April 29, 1997Assignee: Chiron CorporationInventors: Michael S. Urdea, Brian Warner, Thomas Horn
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Patent number: 5614362Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.Type: GrantFiled: September 30, 1994Date of Patent: March 25, 1997Assignee: Chiron CorporationInventors: Michael S. Urdea, Brian Warner, Joyce A. Running, Janice A. Kolberg, Jennifer M. Clyne, Ray Sanchez-Pescador, Thomas Horn
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Patent number: 5359100Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.Type: GrantFiled: August 13, 1993Date of Patent: October 25, 1994Assignee: Chiron CorporationInventors: Michael S. Urdea, Brian Warner, Joyce A. Running, Janice A. Kolberg, Jennifer M. Clyne, Ray Sanchez-Pescador, Thomas Horn
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Patent number: 5124246Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.Type: GrantFiled: April 18, 1989Date of Patent: June 23, 1992Assignee: Chiron CorporationInventors: Michael S. Urdea, Brian Warner, Thomas Horn
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Patent number: 5024095Abstract: A method of diagnosis utilizing a diagnostic locator for detecting sources of electronic circuit malfunction caused by fractured solder connections or other kinetically locatable electronic circuit malfunctions comprises a diagnostic locator using kinetic energy at sonic frequencies which is discriminately applied to particular circuit areas to reveal mechanical intermittance on an accurate basis. The locator includes an elongated non-conductive test probe which is mounted within a housing at one end containing a transducer for kinetically activating the probe. An operator may adjust the kinetic energy being released at the probe tip for greater or lesser propagation upon electronic circuitry being diagnosed. This diagnosis of mechanically malfunctioning electronic circuitry is accomplished while monitoring the output of the circuitry in a conventional manner.Type: GrantFiled: December 5, 1989Date of Patent: June 18, 1991Inventor: Brian Warner
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Patent number: 4872537Abstract: A piston and cylinder arrangement, which includes a piston and piston rod assembly and which is filled with a damper-fluid, is attached to an auxiliary tank by a flow channel. A first restriction in the piston and piston rod assembly substantially controls the low velocity flow of the damper fluid during extension strokes and a second restriction in the piston and piston rod assembly substantially controls high velocity flow of the damper fluid during the extension strokes. A third restriction in the flow channel substantially controls the low velocity flow of the damper-fluid during compression strokes, and a fourth restriction in the flow channel substantially controls the high velocity flow of the damper-fluid during the compression strokes. Substantially unrestricted flow of the damper-fluid through the piston and piston rod assembly is permitted during the compression strokes, and substantially unrestricted flow of the damper-fluid through the flow channel is permitted during extension strokes.Type: GrantFiled: June 6, 1988Date of Patent: October 10, 1989Inventor: Brian Warner
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Patent number: 4868105Abstract: Methods and compositions are provided for rapid detection of nucleic acid sequences. The method employs two reagent sets. The first set is a labelling set comprising: (1) a first nucleic acid sequence probe having an analyte complementary region and a first recognition sequence region and (2) a labelled sequence complementary to the first recognition sequence region. The second set is a capturing set comprising: (1) a second nucleic acid sequence probe having an analyte complementary region and a second recognition sequence region, (2) a specific binding pair member conjugated to a sequence complementary to the second recognition sequence, and (3) a separating means to which is bound a complementary specific binding pair member. The sample and probes are combined under annealing conditions, followed by addition of the other reagents, separation of the bound label from the supernatant and detection of the label in either phase.Type: GrantFiled: December 11, 1985Date of Patent: September 19, 1989Assignee: Chiron CorporationInventors: Mickey Urdea, Brian Warner