Patents by Inventor Brian Weitzner

Brian Weitzner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DESIGNED CYTOKINE COMPOSITIONS AND METHODS OF USE
    Publication number: 20250223330
    Abstract: The disclosure provides a designed cytokine comprising alpha helices H1, H2, H3, and H4, wherein, from an amino terminus to a carboxy terminus, a first loop (L1) connects H1 and H4; a second loop (L2) connects H4 and H2; a third loop (L3) connects H2 and H3; and wherein the polypeptide binds to IL-2 receptor ?? (IL-2R??).
    Type: Application
    Filed: January 11, 2023
    Publication date: July 10, 2025
    Inventors: Scott BOYKEN, Marc LAJOIE, Thaddeus M. DAVENPORT, Howell MOFFETT, Paul Joseph SAMPLE, Brian WEITZNER, Andrew Howen NG
  • ROR1 targeting chimeric antigen receptor
    Patent number: 12144827
    Abstract: The present disclosure relates to polynucleotides encoding a chimeric polypeptide comprising a c-Jun polypeptide, a ROR1-binding protein, and a truncated EGF receptor. Also provided are cells (e.g., T cells) expressing CARs comprising a ROR1-binding protein and overexpressing a c-Jun polypeptide. Overexpression of c-Jun in CAR T cells confers improved properties, e.g., reducing or preventing exhaustion.
    Type: Grant
    Filed: February 24, 2022
    Date of Patent: November 19, 2024
    Assignee: Lyell Immunopharma, Inc.
    Inventors: Spencer Park, Queenie Vong, Blythe Sather, Byoung Ryu, Marc Lajoie, Howell Moffett, Brian Weitzner, Yun Song, Scott Boyken, Neeraj Sharma, Shobha Potluri, Bijan Boldajipour
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20240076342
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: March 21, 2023
    Publication date: March 7, 2024
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Kevin Jude, Brian Weitzner
  • ROR1 TARGETING CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20230022654
    Abstract: The present disclosure relates to polynucleotides encoding a chimeric polypeptide comprising a c-Jun polypeptide, a ROR1-binding protein, and a truncated EGF receptor. Also provided are cells (e.g., T cells) expressing CARs comprising a ROR1-binding protein and overexpressing a c-Jun polypeptide. Overexpression of c-Jun in CAR T cells confers improved properties, e.g., reducing or preventing exhaustion.
    Type: Application
    Filed: February 24, 2022
    Publication date: January 26, 2023
    Applicant: Lyell Immunopharma, Inc.
    Inventors: Spencer PARK, Queenie VONG, Blythe SATHER, Byoung RYU, Marc LAJOIE, Howell MOFFETT, Brian WEITZNER, Yun SONG, Scott BOYKEN, Neeraj SHARMA, Shobha POTLURI, Bijan BOLDAJIPOUR
  • De novo design of potent and selective interleukin mimetics
    Patent number: 11117944
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: September 14, 2021
    Assignees: University Of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Brian Weitzner
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20200347109
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??cheterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: June 23, 2020
    Publication date: November 5, 2020
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Brian Weitzner
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20200339648
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 29, 2020
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Kevin Jude, Brian Weitzner