Patents by Inventor Brian (Xi-Yu) Guo

Brian (Xi-Yu) Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12264315
    Abstract: The present disclosure provides a method for enrichment of at least one target nucleic acid in a library of nucleic acids. A first oligonucleotide is hybridized to a target nucleic acid in library of nucleic acids having first and second adapters. The hybridized first oligonucleotide is extended with a first polymerase, thereby producing a first primer extension complex including the target nucleic acid and the extended first oligonucleotide. The first primer extension complex is captured, enriched relative to the library of nucleic acids, and a second oligonucleotide is hybridized to the target nucleic acid. The hybridized second oligonucleotide is extended with a second polymerase, thereby producing a second primer extension complex including the target nucleic acid and the extended second oligonucleotide, and further liberating the extended first oligonucleotide from the first primer extension complex.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: April 1, 2025
    Assignees: Roche Sequencing Solutions, Inc., Kapa Biosystems, Inc.
    Inventors: Daniel Burgess, Brian Christopher Godwin, Alexander Lovejoy, Bronwen Miller, Jo-Anne Elizabeth Penkler, Joseph Platzer, Martin Ranik
  • Patent number: 12266385
    Abstract: A data storage device comprises a lead actuator that actuates a first read-write head over a first disk and a support actuator that actuates a second read-write head over a second disk. A spindle motor rotates the first and second disks. In response to an emergency power off (EPO) event, a processing device retracts and parks the actuators using an internal supply voltage generated from a back electromotive force (BEMF) voltage of the spindle motor, and brakes the spindle motor. The spindle motor is not braked until both the lead and support actuators have been retracted and parked.
    Type: Grant
    Filed: August 9, 2023
    Date of Patent: April 1, 2025
    Assignee: Western Digital Technologies, Inc.
    Inventors: Brian Johnson, Jaesoo Byoun, Gaku Ikedo, Hideaki Ito, Naoyuki Kagami, Hiroki Watanabe
  • Patent number: 12263219
    Abstract: This invention relates to a therapeutic composition comprising i) at least two immune checkpoint inhibitors, ii) at least one drug selected from a cytokine a cytotoxic or cytostatic chemotherapeutic drug, and combinations thereof, and iii) a cancer vaccine prepared from tumor or cancer cells, or derivatives thereof, that have been prepared through an ex vivo treatment that creates necrotic and/or necroptotic cancer cells while minimizing destruction of cancer antigens. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the therapeutic composition in an amount effective to treat the tumor or cancer.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: April 1, 2025
    Assignee: Rampart Health, L.L.C.
    Inventors: David Granger Bostwick, Brian Rafferty Bostwick, Peter John Littrup
  • Patent number: 12267459
    Abstract: Techniques for managing electronic user profiles are presented herein. An example method includes accessing, from a data structure, a user profile. The user profile can include a profile identifier and a plurality of data fields. The method also includes displaying, on a display device, an interactive user interface. The user interface can include a plurality of user interface action elements. Each of the user interface action elements can be associated with a data field in the data structure. Each of the user interface action elements can also be individually selectable by a respective user action to transmit the associated data field to a remote device. In response to receiving a selection of a user interface action element, the method can further include transmitting the associated data field and the profile identifier to a router configured to send, based on the profile identifier, the associated data field to the remote device.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: April 1, 2025
    Assignee: eBay Inc.
    Inventors: Nikhil Firke, Michael Chan, Ralph Forsythe, Brian Peter Dickson, Todd Ryan Palmer
  • Patent number: 12266257
    Abstract: A security enclosure, components thereof, and associated methods. In one embodiment, the security enclosure is sized and shaped to hold a firearm, and the security enclosure can be used with a monitor and an associated magnet. The security enclosure system includes first and second enclosure portions movable with respect to one another to open and close the system. The first enclosure portion includes a first holder, the second enclosure portion includes a second holder, and at least one of the first or second holders holds the security monitor in an interior when the enclosure is closed. The other of the at least one of the first or second holders holds the magnet in the interior when the enclosure is closed. The first and second holders are adjacent to each other when the enclosure is closed and are spaced apart from each other when the enclosure is open.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: April 1, 2025
    Assignee: AOB Products Company
    Inventors: Brett Eckelkamp, Kyle Martin, Michael Cottrell, Brian Steere, James Tayon, Fernando Coviello, Tony Galbreath, Curtis Smith, Timothy S. Kinney, Matthew Kinamore, Anthony Vesich, Mark Dalton, Justin Burke, Dennis W. Cauley, Jr., Seth Wheeler, Michael Lindsay, Ryan Varnum
  • Patent number: 12267328
    Abstract: Methods are provided in which a network device hosts distinct network access resources that are managed by different entities. The method includes obtaining a request for partitioning one or more network resources of an on-premise network device for connecting one or more endpoints to a first network managed by a first entity. The on-premise network device connects one or more endpoints to a second network managed by a different entity. The method further involves partitioning, based on the request, the one or more network resources and connecting the one or more endpoints to the first network using the one or more network resources. The one or more network resources are managed by the first entity while at least one other network resource of the on-premise network device is managed by the different entity and is associated with connecting the one or more endpoints to the second network.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: April 1, 2025
    Assignee: CISCO TECHNOLOGY, INC.
    Inventors: Nagendra Kumar Nainar, Carlos M. Pignataro, John Matthew Swartz, Paul Brian Giralt, David John Zacks, Gonzalo Salgueiro
  • Patent number: 12266725
    Abstract: A lateral III-N device has a vertical gate module with III-N material orientated in an N-polar or a group-III polar orientation. A III-N material structure has a III-N buffer layer, a III-N barrier layer, and a III-N channel layer. A compositional difference between the III-N barrier layer and the III-N channel layer causes a 2DEG channel to be induced in the III-N channel layer. A p-type III-N body layer is disposed over the III-N channel layer in a source side access region but not over a drain side access region. A n-type III-N capping layer over the p-type III-N body layer. A source electrode that contacts the n-type III-N capping layer is electrically connected to the p-type III-N body layer and is electrically isolated from the 2DEG channel when the gate electrode is biased relative to the source electrode at a voltage that is below a threshold voltage.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: April 1, 2025
    Assignee: Transphorm Technology, Inc.
    Inventors: Umesh Mishra, Davide Bisi, Geetak Gupta, Carl Joseph Neufeld, Brian L. Swenson, Rakesh K. Lal
  • Patent number: 12263752
    Abstract: A system includes data processing hardware and memory hardware. The memory hardware is in communication with the data processing hardware and stores instructions that when executed on the data processing hardware cause the data processing hardware to perform certain operations. The operations include receiving a temperature corresponding to a battery, and determining whether the temperature is greater than a predetermined threshold temperature. The operations also include, when the temperature is greater than the predetermined threshold temperature, actuating an ejector to eject the battery from a power supply assembly.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: April 1, 2025
    Assignee: AVL Mobility Technologies, Inc.
    Inventors: Bruce Falls, Adrian Quintana, Alwin Lutz, Scott Kochan, Brian Moran
  • Patent number: 12263041
    Abstract: A signal processing pathway for an ultrasonic imaging device is provided. The signal processing pathway is configured to operate in a frequency range of 1 MHz to 40 MHz inclusive and a voltage range of ?80 V to +80 V inclusive.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: April 1, 2025
    Assignee: EXACT IMAGING INC.
    Inventors: Brian C. Wodlinger, Jerrold Wen, Zahra Torbatian, Simpson Lam
  • Patent number: 12262757
    Abstract: A tobacco pipe comprising a tobacco burning chamber, a stem having a bore communicating with the interior of the chamber, wherein the chamber comprises a brass musical instrument mouthpiece, and the stem comprises the lead tube of a brass musical instrument.
    Type: Grant
    Filed: September 4, 2022
    Date of Patent: April 1, 2025
    Inventor: Brian Stall
  • Patent number: 12264892
    Abstract: An electrical weapon may include a shaft, an arm, first electrode, and a second electrode. The arm may be pivotably coupled to the shaft and the first electrode may be coupled to the arm such that a position of the electrode changes in accordance with a change in position of the arm. The electrical weapon may be an electrified baton. The electrical weapon may further include a second arm pivotably coupled to the shaft. The second electrode may be coupled to the second arm. The electrical weapon may enable a stimulus signal to be applied via the electrodes at a distance from a user of the electrical weapon, thus improving safety of the user. An electrode may include an electrode array comprising a plurality of conductors and a stimulus signal may be conducted between pairs of the conductors via ionization of air between the conductors.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: April 1, 2025
    Assignee: Axon Enterprise, Inc.
    Inventors: Patrick W Smith, Lynn Kern, Mark Eastwood, Hans Moritz, Nathan Patulski, Brian Fairbanks
  • Patent number: 12265953
    Abstract: The present invention generally relates to computer systems, methods and program products that allow a digital asset exchange to provide an option to customers to lend all or a portion of the digital assets associated with at least a first blockchain and held by the exchange on behalf of the customer in exchange for payments such as interest.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: April 1, 2025
    Assignee: Gemini IP, LLC
    Inventors: Thomas Hungerford Harrison, Thomas Vaniotis, Brian Keogh, Noah Cornwell, Neeraj Mishra, Ira Auerbach, Jack Sutton
  • Patent number: 12263480
    Abstract: An analytical and/or diagnostic device that includes a compartment for reagents stored within the device and uses surface energy gradient coatings to move liquid through fluid passages. The device can include a sampler for collecting a sample, a reaction region for reagents to react with the sample, and a detection region to detect any species of interest present in the sample.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: April 1, 2025
    Inventor: Brian David Babcock
  • Patent number: 12264756
    Abstract: An illustrative valve block includes a plate, a fluid transfer block, and a diaphragm. The plate includes a channel configured to receive a first fluid and a recess connected to the channel. The fluid transfer block includes an inlet connection configured to receive a second fluid and an outlet connection. The fluid transfer block also includes a plurality of valve inlet bores connected to the inlet connection. The plurality of valve inlet bores are distributed along at least part of a first curved shape. The fluid transfer block further includes a plurality of valve outlet bores each fluidly connected to the outlet connection. The plurality of valve outlet bores are distributed along at least part of a second curved shape. The diaphragm is between the pressure plate and the fluid transfer block. The plurality of valve inlet bores and the plurality of valve outlet bores adjoin the recess.
    Type: Grant
    Filed: August 29, 2023
    Date of Patent: April 1, 2025
    Assignee: Tosoh Bioscience LLC
    Inventors: Brian A. Harbrecht, Robert Charles Mierendorf, Scott G. Manke
  • Patent number: 12263521
    Abstract: A boron steel high pressure cartridge case and method of manufacturing the same is provided. The method includes cold forming a cartridge case into a drawn blank or a tubular component; annealing the cartridge case using a belt furnace, flame furnace, induction furnace, or a batch furnace; performing a machine ejector slot and trim on the cartridge case; forming the shoulder and neck of the cartridge case; performing a heat treatment of the cartridge case; tempering the cartridge case; and coating the cartridge case with a zinc nickel plating. The cartridge case is fabricated of boron steel including ?1.0% boron.
    Type: Grant
    Filed: October 19, 2023
    Date of Patent: April 1, 2025
    Assignee: LUVATA OHIO, INC.
    Inventor: Brian Swank
  • Patent number: 12263024
    Abstract: A medical imaging system includes a CT imaging system including a gantry having a bore, rotatable about an axis of rotation. The CT imaging system includes a table configured to move a subject to be imaged into and out of the bore, a radiation source mounted on the gantry and configured to emit an X-ray beam, and a detector configured to detect the X-ray beam. The medical imaging system includes a LiDAR scanning system physically coupled to the CT imaging system. The LiDAR scanning system is configured to acquire data of the subject from different angular positions relative to the axis of rotation. The medical imaging system includes processing circuitry configured to receive the data acquired with the LiDAR scanning system, to generate a three-dimensional (3D) measurement of the subject, and to utilize the 3D measurement in a subsequent workflow process for a CT scan of the subject.
    Type: Grant
    Filed: August 16, 2022
    Date of Patent: April 1, 2025
    Assignee: GE Precision Healthcare LLC
    Inventors: Arka Datta, Brian Edward Nett
  • Patent number: 12267457
    Abstract: A system and method for enhancing communication between multiple parties includes a first user accessing a communication device; initiating a communication connection to a receiving communication device of a second user; and wherein at least one of the communication devices includes a list of enabled universal communication attributes of the user, utilizing one or more of the enabled communication attributes to complete the communication connection between the initiating and receiving communication devices. A user can select a desired communication attribute or multiple attributes which can be stored in the user's profile. The enabled attributes can be utilized by a network accessing the user's profile to complete the communication connection.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: April 1, 2025
    Assignee: Rochester Institute of Technology
    Inventors: Gary Behm, Brian Trager, Shareef Ali, Mark Jeremy, Byron Behm
  • Patent number: 12265102
    Abstract: A non-contact electric potential meter system to determine voltage between an AC conductor and a reference potential without direct electrical contact to the conductor. A housing provides a shielded measurement region that excludes other conductors and holds power supply means; an AC voltage sensing mechanism includes a conductive sense plate and an electrical connection to the reference potential. Waveform-sensing electronic circuitry obtains an AC voltage waveform induced by capacitive coupling between the conductor and the conductive sense plate. Capacitance-determining electronic circuitry obtains a scaling factor based on the coupling capacitance formed between the conductor and the conductive sense plate. Signal processing electronic circuitry uses the AC voltage waveform and the coupling capacitance-based scaling factor to obtain the voltage between the conductor and the reference potential.
    Type: Grant
    Filed: March 28, 2023
    Date of Patent: April 1, 2025
    Assignee: 4QUADRANT NETWORKS INC.
    Inventors: Prabal Dutta, Michael C. Lorek, Brian Andika Purnomo, Aaron Block
  • Patent number: 12265574
    Abstract: A media application selects, from a collection of images associated with a user account, candidate pairs of images, where each pair includes a first static image and a second static image from the user account. The media application applies a filter to select a particular pair of images from the candidate pairs of images. The media application generates, using an image interpolator, one or more intermediate images based on the particular pair of images. The media application generates a video that includes three or more frames arranged in a sequence, where a first frame of the sequence is the first static image, a last frame of the sequence is the second static image, and each of the one or more intermediate images is a corresponding intermediate frame of the sequence between the first frame and the last frame.
    Type: Grant
    Filed: December 20, 2023
    Date of Patent: April 1, 2025
    Assignee: Google LLC
    Inventors: Janne Kontkanen, Jamie Aspinall, Dominik Kaeser, Navin Sarma, Brian Curless, David Salesin
  • Patent number: D1068562
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: April 1, 2025
    Assignee: ZERO MOTORCYCLES, INC.
    Inventors: Matthew Bentley, Alan Valencia, Thomas Zipprian, Brian Wismann