Abstract: Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient’s blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate’s composition can be selected such that charge neutrality is maintained.

Abstract: Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Abstract: Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Abstract: The invention relates to a bronze-tinted or grey-tinted soda lime silicate glass, in particular for the manufacture of flat glass by the casting process or by the float process, with a basic composition for the soda lime silicate glass of:______________________________________ SiO.sub.2 : 66-74 weight % Al.sub.2 O.sub.3 : 0-3 weight % TiO.sub.2 : 0-0.15 weight % CaO: 7-12 weight % MgO: 2-6 weight % Na.sub.2 O: 10-15 weight % K.sub.2 O: 0-3 weight % BaO: 0-0.04 weight % SO.sub.3 : 0.1-0.4 weight % ______________________________________The invention resides in the fact that it contains the following colorants additives: ______________________________________ Fe.sub.2 O.sub.3 : 0-0.45 weight % V.sub.2 O.sub.5 : 0.0-0.5 weight % MnO.sub.2 : 0.5-2 weight % NiO: 0.0-0.05 weight % CuO: 0.0-0.1 weight % CoO: 0.0-0.008 weight % ______________________________________the sum of the weight percentages of the constituents forming the soda lime silicate glass being 100.

Abstract: A low alkali borosilicate glass composition comprising60 to 78% by weight of SiO.sub.210 to 25% by weight of B.sub.2 O.sub.33.5 to 6.0% by weight of R.sub.2 O, wherein R.sub.2 O represents Na.sub.2 O, K.sub.2 O and/or Li.sub.2 O,2.0 to 6.5% by weight of CeO.sub.2, and0.25 to 8.0% by weight of Sb.sub.2 O.sub.3 and/or As.sub.2 O.sub.3,the percentages being based on the total weight of the glass composition. The glass composition of the invention are suitable for use as protective covers for solar cells, especially solar cells which are used in satellites.

Abstract: Glass compositions with a particularly high alkali resistance comprise, in weight percentages:______________________________________ SiO.sub.2 45 to 65% ZrO.sub.2 6 to 20% RO 20 to 45% ______________________________________The total of SiO.sub.2 + ZrO.sub.2 + RO being not less than 94% by weight of the glass, where RO represents CaO, in an amount from 20 to 45%, with or without lesser amounts of further divalent oxides of the group consisting of MgO, SrO, BaO and ZnO, the balance (if any) of the composition consisting of compatible constituents such as TiO.sub.2, Al.sub.2 O.sub.3, B.sub.2 O.sub.3, Fe.sub.2 O.sub.3, F.sub.2 and R.sub.2 O, where R.sub.2 O represents K.sub.2 O, Na.sub.2 O or Li.sub.2 O, the amount of any one of these compatible constituents not exceeding 5% by weight. Preferably R.sub.2 O does not exceed 3%.

Abstract: Alkali-resistant continuously-drawn glass fibers, for use in the reinforcement of cement products, are composed of SiO.sub.2 67 to 82 mol.%, ZrO.sub.2 7 to 10 mol.%, R.sub.2 O 9 to 22.5 mol.% (where R = Na, up to 5 mol.% of which may be replaced by Li or K), F.sub.2 3 to 9 mol.% and Al.sub.2 O.sub.3 (computed as AlO.sub.1.5) 0 to 5 mol.%, the permissible maximum value of the total of SiO.sub.2 + ZrO.sub.2 + AlO.sub.1.5 being on a sliding scale dependent on the content of ZrO.sub.2 and ranging (when F.sub.2 = 9 mol.%) from 89 mol.% when ZrO.sub.2 is 7 mol.% down to 87 mol.% when ZrO.sub.2 is 10 mol.%, the said maximum value being reduced by a further 5 mol.% over the whole scale when F.sub.2 = 3 mol.%. The fiberizing temperature is below 1350.degree. C and the liquidus temperature is at least 40.degree. C below the fiberizing temperature. Preferably, to ensure that the fiberizing temperature is below 1320.degree. C, the said maximum value of SiO.sub.2 + ZrO.sub.2 + AlO.sub.1.5 is further reduced by 1 mol.