Patents by Inventor Brian Yichiun Chow

Brian Yichiun Chow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190352347
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Patent number: 10472399
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 10472398
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 10106584
    Abstract: Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modified haloarcula halorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: October 23, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
  • Patent number: 9668804
    Abstract: In an automated methodology for carrying out in vivo cell patch clamping, a cell patch clamping device is automatically moved into position and targeted to a neuron. Neuron contact is determined by analyzing the temporal series of measured resistance levels at the cell patch clamping device as it is moved. The difference between successive resistance levels is computed and compared to a threshold, which must be exceeded for a minimum number of computations before neuron contact is assumed. Pneumatic control methods are used to achieve gigaseal formation and cell break-in, leading to whole-cell patch clamp formation. An automated robotic system capable of performing this methodology automatically performs patch clamping in vivo, automatically detecting cells by analyzing the temporal sequence of electrode impedance changes.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: June 6, 2017
    Assignees: Massachusetts Institute of Technology, Georgia Tech Research Corporation
    Inventors: Suhasa Bangalore Kodandaramaiah, Edward Stuart Boyden, Crag Richard Forest, Brian Yichiun Chow, Giovanni Talei Franzesi
  • Publication number: 20170088590
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 30, 2017
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Publication number: 20170044219
    Abstract: Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modified haloarcula halorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.
    Type: Application
    Filed: September 30, 2016
    Publication date: February 16, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
  • Patent number: 9500641
    Abstract: Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modified haloarcula halorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: November 22, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
  • Publication number: 20160039902
    Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.
    Type: Application
    Filed: August 4, 2015
    Publication date: February 11, 2016
    Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Publication number: 20150192567
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion pumps (LAIPs).
    Type: Application
    Filed: January 20, 2015
    Publication date: July 9, 2015
    Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
  • Patent number: 8957028
    Abstract: The invention, in some aspects, relates to compositions and methods for altering cell activity and function. The invention also relates, in part, to the use of light-activated ion pumps (LAIPs) such as a light-activated ion pump polypeptide that when expressed in an excitable cell and contacted with a red light silences the excitable cell, wherein the polypeptide sequence of the light-activated ion pump comprises a wild-type or modified halomicrobium or haloarcula halorhodopsin polypeptide sequence.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: February 17, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
  • Publication number: 20140324134
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: November 12, 2012
    Publication date: October 30, 2014
    Applicants: Massachusetts Institute of Technology, The Governrs of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Publication number: 20130225963
    Abstract: In an automated methodology for carrying out in vivo cell patch clamping, a cell patch clamping device is automatically moved into position and targeted to a neuron. Neuron contact is determined by analyzing the temporal series of measured resistance levels at the cell patch clamping device as it is moved. The difference between successive resistance levels is computed and compared to a threshold, which must be exceeded for a minimum number of computations before neuron contact is assumed. Pneumatic control methods are used to achieve gigaseal formation and cell break-in, leading to whole-cell patch clamp formation. An automated robotic system capable of performing this methodology automatically performs patch clamping in vivo, automatically detecting cells by analyzing the temporal sequence of electrode impedance changes.
    Type: Application
    Filed: November 13, 2012
    Publication date: August 29, 2013
    Applicants: Georgia Tech Research Corporation, Massachusetts Institute of Technology
    Inventors: Suhasa Bangalore Kodandaramaiah, Edward Stuart Boyden, Crag Richard Forest, Brian Yichiun Chow, Giovanni Talei Franzes
  • Patent number: 8367435
    Abstract: In exemplary implementations of this invention, hydrothermal synthesis of zinc oxide nanowires is morphologically controlled. Metal complex ions are used to suppress growth in a face-selective manner, by electrostatic crystal growth inhibition. This permits the aspect ratio (height/diameter) of the nanowires to be dynamically tuned over a wide range, from needle-like nanowires that are efficient field emitters to flattened nanowires with a platelet-like shape. The nanowire synthesis is all inorganic and occurs at low temperatures (e.g., <=60° C.). The growth inhibition may be predictively modeled, using speciation plots and treating non-zinc complex ions as ligands. Microfluidic channels may be used for the synthesis, with different solutions flowing down different channels, permitting nanowires with different properties to be synthesized in parallel.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: February 5, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Brian Yichiun Chow, Jaebum Joo, Manu Prakash
  • Publication number: 20120214188
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion channels (LAICs).
    Type: Application
    Filed: November 14, 2011
    Publication date: August 23, 2012
    Inventors: Nathan Klapoetke, Amy Chuong, Brian Yichiun Chow, Edward Boyden, Xue Han, Gane Ka-Shu Wong
  • Publication number: 20120121542
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion pumps (LAIPs).
    Type: Application
    Filed: November 14, 2011
    Publication date: May 17, 2012
    Inventors: Amy Chuong, Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Xue Han
  • Publication number: 20110143464
    Abstract: In exemplary implementations of this invention, hydrothermal synthesis of zinc oxide nanowires is morphologically controlled. Metal complex ions are used to suppress growth in a face-selective manner, by electrostatic crystal growth inhibition. This permits the aspect ratio (height/diameter) of the nanowires to be dynamically tuned over a wide range, from needle-like nanowires that are efficient field emitters to flattened nanowires with a platelet-like shape. The nanowire synthesis is all inorganic and occurs at low temperatures (e.g., <=60° C.). The growth inhibition may be predictively modeled, using speciation plots and treating non-zinc complex ions as ligands. Microfluidic channels may be used for the synthesis, with different solutions flowing down different channels, permitting nanowires with different properties to be synthesized in parallel.
    Type: Application
    Filed: December 3, 2010
    Publication date: June 16, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Brian Yichiun Chow, Jaebum Joo, Manu Prakash