Abstract: A system and method for assessing disease progression receives digital health data about patients over a network from a plurality of diagnostic instruments, IoT devices, analytical software, systems, and electronic health records. Electronic Patient Reported Outcome (PRO) questionnaires are created by clinicians and periodically administered to patients on a remote computing device. The PROs and other digital health data are processed, analyzed, and scored in real time. Digital reports including the scores and other health metrics are instantaneously generated providing valuable hidden insights into disease progression and treatment efficacies in real-time. A clinical advisor generates an interactive dashboard comprising comprehensive information about patients and enables doctors to validate their clinical decisions and discover new treatment protocol idea.