Abstract: A continuous process for nano-emulsification that is performed by concentration phase inversion in a microfluidic reactor, including the following steps: (a) injection of an aqueous phase into a first microchannel, the first microchannel opening onto a formulation chamber, (b) injection, into a second microchannel, of a fatty phase including one or more fatty substances immiscible in the aqueous phase, and one or more surfactants, the second microchannel opening into the formulation chamber, then (c) mixing of the aqueous phase and the fatty phase in the formulation chamber, then (d) recovering, at the output of the formulation chamber, a suspension including lipid nanocapsules. Also, the lipid nanocapsules obtainable by the process, and the use of the lipid nanocapsules as nanovectors for pharmacologically active ingredients.

Abstract: Disclosed is an implantable medical device for locoregional injection and/or sampling in the lumen of a blood vessel or in a parenchyma, including a microfluidic chip and a cover. The microfluidic chip includes at least one microfluidic channel extending from a first face of the microfluidic chip to a second face of the microfluidic chip. The cover includes at least two hollow micro-needles protruding from the cover. The cover is fixed to the second surface of the microfluidic chip so the microfluidic channel is in fluid connection with the at least two hollow micro-needles. The length of the hollow micro-needles projecting from the cover is configured such that when the cover is implanted on the outer wall of a blood vessel or on a parenchyma, the end of the hollow micro-needles penetrates into the lumen of the blood vessel or into the parenchyma.