Patents by Inventor Bridgette Alexandrou

Bridgette Alexandrou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination of insulin and ascorbate to enhance wound healing
    Patent number: 8921312
    Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: December 30, 2014
    Assignee: University of South Florida
    Inventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou
  • COMBINATION OF INSULIN AND ASCORBATE TO ENHANCE WOUND HEALING
    Publication number: 20110027884
    Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
    Type: Application
    Filed: October 14, 2010
    Publication date: February 3, 2011
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou
  • Combination of insulin and ascorbate to enhance wound healing
    Patent number: 7834153
    Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: November 16, 2010
    Assignee: University of South Florida
    Inventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou
  • Combination of Insulin and Ascorbate to Enhance Wound Healing
    Publication number: 20070281882
    Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
    Type: Application
    Filed: June 5, 2007
    Publication date: December 6, 2007
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou