Abstract: A protective cover arrangement 10 for the lower portion 101 of the front face 102 and base portion 103 of a dialysis machine 100. The arrangement 10 includes a bottom cover unit 12 that includes a generally rectangular horizontal framework member 30 having a shallow collection receptacle 31 that covers the front end of the base portion 103 of the dialysis machine 100, and a raised wall panel 35 that is overlapped by the upper portion 104 of the front face 102 of the dialysis machine 100, a liquid collection reservoir 33 disposed on the back end of the base portion 103 of the dialysis machine 100, and at least one gutter 32 operatively associated with one side of the dialysis machine 100, wherein the at least one gutter 32 establishes fluid communication between the receptacle 31 and the reservoir 33.